July 25, 2024
Image credit: Hoda Jaffal & Mounia Kortebi
07/25/2024
Research Article
Alternative transcription start site (altTSS) usage is one of the major means of gene regulation in animals but is unknown in non-yeast fungi. Thi Tuong Vi Dang, Guilhem Janbon and co-workers reveal widespread altTSS in Cryptococcus that alters gene expression and protein targeting, regulated by a single transcription factor, Tur1, in response to environmental cues.
Image credit: pbio.3002724
Current Issue June 2024
07/24/2024
Research Article
The Wnt pathway promotes resistance to DNA damage induced by ionizing radiation in several human cancers, but how? Ben Ewen-Campen and Norbert Perrimon show that Wnt signaling in the Drosophila wing imaginal disc modulates the DNA damage response through EGFR, protecting cells from apoptosis induced by DNA double-strand breaks..
Image credit: pbio.3002547
07/23/2024
Research Article
Neurons are thought to be the primary source of pathogenic amyloid beta (Aβ) in Alzheimer's disease. Rikesh Rajani, Marc Aurel Busche and co-authors identify oligodendrocytes as significant contributors to Aβ production and show that suppressing Aβ in oligodendrocytes rescues early neuronal dysfunction in a mouse model of Alzheimer's disease.
Image credit: pbio.3002727
07/23/2024
Meta-Research Article
Research awards are an integral part of the universal “prestige economy” in science. Malgorzata Lagisz, Shinichi Nakagawa and colleagues use cross-disciplinary data to explore the level of transparency of publicly available award descriptions and assessment criteria, asking whether such awards contribute to or propagate existing reproducibility crises and inequities in science.
Image credit: Pixabay user Mimzy
07/22/2024
Research Article
Intercellular communication between neural crest cells and placode cells is critical for the formation of trigeminal ganglion during development. Yanel Bernardi, Pablo Strobl-Mazzulla and colleagues reveal that miR-203 from neural crest cells is selectively secreted in extracellular vesicles and mediates this communication.
Image credit: pbio.3002074
07/19/2024
Short Reports
The complexity of metabolic dysfunction-associated steatohepatitis (MASH) has impaired the development of pharmacological treatments for the condition. Heejin Jun, Shanshan Liu, Jun Wu and co-workers show that nicotinic acetylcholine receptor signaling serves as an intrinsic protective mechanism against extended metabolic stress in the liver.
Image credit: pbio.3002728
07/15/2024
Essay
Aude Bernheim, Jean Cury and Enzo Poirier introduce the concept of ancestral immunity; the set of immune modules conserved between prokaryotes and eukaryotes, discussing the topology of ancestral immunity and an evolutionary scenario for its existence.
Image credit: pbio.3002717
07/08/2024
Essay
Omer Sharon, Eti Ben Simon, Matthew Walker and co-authors highlight eight of the most exciting new discoveries within sleep science, discussing how these have expanded our understanding of sleep's function at the cellular, organismal, and societal levels.
Image credit: pbio.3002684
07/01/2024
Unsolved Mystery
Mitochondria come in many shapes and sizes. Noga Preminger and Maya Schuldiner explore the diverse processes that influence mitochondrial shape and network formation, highlighting gaps in our understanding of mitochondrial architecture.
Image credit: pbio.3002671
06/11/2024
Editorial
The planetary outlook for biodiversity is dire. Leah Gerber and Gwenllian Iacona introduce a new Collection of articles that discuss the data we have and the data we need for more effective conservation policies.
Image credit: Leah Gerber
Translating conservation and biodiversity research from the field into the real world is a complex problem. This collection discusses issues around economics, policy, and how to do research that answers questions that decision makers have.
Symbiosis research has become a holistic and pervasive field with a mature theoretical basis. This collection showcases symbiotic relationships across the tree of life, exploring their evolutionary basis and underlying mechanisms.
PLOS Biology is 20 and we are celebrating with a collection that contains articles that look back at landmark studies that we published, others that look past and future, and others discussing how publishing and open science have evolved and what is to come.
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This collection explores engineering strategies to help us adapt plants to a changing climate, including breeding techniques, genome engineering, synthetic biology and microbiome engineering.
The green collection explores biological solutions that could be applied to reduce CO2 emissions, get rid of non-degradable plastics, produce food in a sustainable manner or generate energy.
July 28 - August 2
Meet Senior Editor Roli Roberts (rroberts@plos.org)
July 28 - August 2
Meet Senior Editor Richard Hodge (rhodge@plos.org)
September 1 - 4
Meet Associate Editor Melissa Vazquez Hernandez (mvazquezhernandez@plos.org)
September 9 - 11
Meet Senior Editor Ines Alvarez-Garcia (ialvarez-garcia@plos.org)
September 9 - 10
Meet Associate Editor Suzanne de Bruijn (sbruijn@plos.org)
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