Professor of Cardiopulmonary Sciences, Faculty of Science and Medway School of Pharmacy, University of Kent, Canterbury, UK. Visiting Professor of Medicine, Imperial College Medical School, London, UK , He was trained as clinical Cardiac Electrophysiology art St. Bartholomew’s Hospital Medical School (1981-1984), He became a Director of the Clinical Cardiac Electrophysiology Lab at St Georges Hospital from 1985-1990. He became Honorary Senior Lecture in Cardiology at St. George’s Medical school and Chief Scientific Advisor to Pfizer Research and development laboratories in UK. He was appointed as a professor of Cardiopulmonary Sciences, University of Kent in 2005. Prof Butrous co-founded the Pulmonary Vascular Research Institute (PVRI) (www.pvri.net) in 2006. The PVRI is a non-for-profit organization and think tank. The Institute brings together international academic leaders representing a wide range of specialties in pulmonary vascular diseases from around the world into a single focused institute with the resources and expertise to conduct basic and translational and clinical research at a level that no single academic institution could achieve. The main interest of the institute is in the field of Pulmonary Vascular Diseases in the developing world. It conducted various educational and research activities in this area in the last 5 years. He is now the Managing Director of this institute. Prof. Butrous main research Interests are in Ventricular repolarization which include Signal analysis and computer modeling of cardiac electrical signal and it impact on cardiac arrhythmias. Since 1997, he had a leading role in the studying the pathobiology of Pulmonary Vascular Diseases. He is coordinating international effort to examine the epidemiological pattern of Pulmonary vascular diseases secondary to Schistosomiasis world wide Address: United Kingdom
Intravenous sildenafil for postoperative pulmonary hypertension in children with congenital heart... more Intravenous sildenafil for postoperative pulmonary hypertension in children with congenital heart disease
The heart is extensively innervated by both the sympathetic and parasympathetic system. These ner... more The heart is extensively innervated by both the sympathetic and parasympathetic system. These nerves regulate both the electrical and mechanical functions of the heart and play a very important role in the stabilization of cardiac function. Disturbances in this regulatory mechanism may play an important role in the genesis of cardiac arrhythmias.
A wide variety of infectious diseases are major contributors to the causation of pulmonary vascul... more A wide variety of infectious diseases are major contributors to the causation of pulmonary vascular disease and, consequently, pulmonary hypertension, especially in the developing world. Schistosomiasis and human immunodeficiency virus are the most common infections that are known to contribute to pulmonary hypertension worldwide. The resultant inflammation and immunologic milieu caused by infection are the main pathologic processes affecting the pulmonary vasculature.
Abstract. Quinine is a famous class of drugs over the last 500 years of the history of medicine. ... more Abstract. Quinine is a famous class of drugs over the last 500 years of the history of medicine. It does not treat disease symptoms, but rather modifies the underlying mechanism of the disproportionate effect of inflammation and immunity. Thus, it is described under the rubric of DMARD (Disease-Modifying Anti-Rheumatic Drugs). The mutation of SARS-CoV-1 to SARS-CoV-2 has given the virus the advantage of bypassing many defenses, allowing the virus to spread widely, causing the current pandemic. During this progressive global crisis, the medical community began to repurpose many of the available drugs to treat SARS-CoV-2 infection. Many antiviral drugs have been proposed. Using hydroxychloroquine for the prevention and treatment of COVID-19 has received significant attention in 2020. The idea of using hydroxychloroquine came from previous experience during the initial outbreak of MERS in 2012 when physicians and other scientists conducted random observations on various approved ...
Schistosomiasis is the most common parasitic disease associated with pulmonary arterial hypertens... more Schistosomiasis is the most common parasitic disease associated with pulmonary arterial hypertension (PAH). It induces remodeling via complex inflammatory processes produced by the parasite eggs. Changes in the pulmonary vasculature after Schistosoma infection are common, but may not always be associated with a clinical manifestation of PAH. Those patients who presented with PAH show clinical signs and symptoms that are not distinguishable from other forms of PAH.
Rationale: Iloprost is effective for the treatment of pulmonary hypertension. It acts through ele... more Rationale: Iloprost is effective for the treatment of pulmonary hypertension. It acts through elevation of cAMP by binding to the prostacyclin receptor (IP receptor). However, there is evidence that patients with severe pulmonary hypertension have decreased expression of the IP receptor in the remodeled pulmonary arterial smooth muscle. Objectives: We hypothesized that prostanoid receptors other than the IP receptor are involved in signal transduction by iloprost. Methods: Immunoblotting was used to detect the IP and prostanoid EP4 receptor in lung tissue from patients with idiopathic pulmonary arterial hypertension, and immunohistochemistry was used to detect these receptors in lung sections from rats treated with monocrotaline (MCT28d). Protein and mRNA were isolated from pulmonary arterial smooth muscle cells (PASMCs) from control and MCT28d rats treated with AH6809 (an EP2 receptor antagonist)
Intravenous sildenafil for postoperative pulmonary hypertension in children with congenital heart... more Intravenous sildenafil for postoperative pulmonary hypertension in children with congenital heart disease
The heart is extensively innervated by both the sympathetic and parasympathetic system. These ner... more The heart is extensively innervated by both the sympathetic and parasympathetic system. These nerves regulate both the electrical and mechanical functions of the heart and play a very important role in the stabilization of cardiac function. Disturbances in this regulatory mechanism may play an important role in the genesis of cardiac arrhythmias.
A wide variety of infectious diseases are major contributors to the causation of pulmonary vascul... more A wide variety of infectious diseases are major contributors to the causation of pulmonary vascular disease and, consequently, pulmonary hypertension, especially in the developing world. Schistosomiasis and human immunodeficiency virus are the most common infections that are known to contribute to pulmonary hypertension worldwide. The resultant inflammation and immunologic milieu caused by infection are the main pathologic processes affecting the pulmonary vasculature.
Abstract. Quinine is a famous class of drugs over the last 500 years of the history of medicine. ... more Abstract. Quinine is a famous class of drugs over the last 500 years of the history of medicine. It does not treat disease symptoms, but rather modifies the underlying mechanism of the disproportionate effect of inflammation and immunity. Thus, it is described under the rubric of DMARD (Disease-Modifying Anti-Rheumatic Drugs). The mutation of SARS-CoV-1 to SARS-CoV-2 has given the virus the advantage of bypassing many defenses, allowing the virus to spread widely, causing the current pandemic. During this progressive global crisis, the medical community began to repurpose many of the available drugs to treat SARS-CoV-2 infection. Many antiviral drugs have been proposed. Using hydroxychloroquine for the prevention and treatment of COVID-19 has received significant attention in 2020. The idea of using hydroxychloroquine came from previous experience during the initial outbreak of MERS in 2012 when physicians and other scientists conducted random observations on various approved ...
Schistosomiasis is the most common parasitic disease associated with pulmonary arterial hypertens... more Schistosomiasis is the most common parasitic disease associated with pulmonary arterial hypertension (PAH). It induces remodeling via complex inflammatory processes produced by the parasite eggs. Changes in the pulmonary vasculature after Schistosoma infection are common, but may not always be associated with a clinical manifestation of PAH. Those patients who presented with PAH show clinical signs and symptoms that are not distinguishable from other forms of PAH.
Rationale: Iloprost is effective for the treatment of pulmonary hypertension. It acts through ele... more Rationale: Iloprost is effective for the treatment of pulmonary hypertension. It acts through elevation of cAMP by binding to the prostacyclin receptor (IP receptor). However, there is evidence that patients with severe pulmonary hypertension have decreased expression of the IP receptor in the remodeled pulmonary arterial smooth muscle. Objectives: We hypothesized that prostanoid receptors other than the IP receptor are involved in signal transduction by iloprost. Methods: Immunoblotting was used to detect the IP and prostanoid EP4 receptor in lung tissue from patients with idiopathic pulmonary arterial hypertension, and immunohistochemistry was used to detect these receptors in lung sections from rats treated with monocrotaline (MCT28d). Protein and mRNA were isolated from pulmonary arterial smooth muscle cells (PASMCs) from control and MCT28d rats treated with AH6809 (an EP2 receptor antagonist)
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