Purpose: To investigate Heliotropium strigosum whole plant extract for its potential to reduce th... more Purpose: To investigate Heliotropium strigosum whole plant extract for its potential to reduce the blood glucose level of alloxan-induced diabetic mice.Methods: Preliminary phytochemical analysis was carried out using standard procedures. Diabetes was induced in Balb/c mice by injecting alloxan (200 mg/kg i.p.). The crude methanol extract of Heliotropium strigosum (Hs.Cr, 30, 100 and 300 mg/kg doses) was administered daily to alloxan-induced diabetic mice for 15 days and its effect on fasting blood glucose levels, body weight and oral glucose tolerancewas evaluated. Two control groups (non-diabetic control and diabetic control) received normal saline (0.2 ml). Metformin (500 mg/kg) was used as reference standard.Results: Heliotropium strigosum showed positive for the presence of alkaloids, tannins and flavonoids. The extract (30, 100 and 300 mg/kg) caused significant reduction in the fasting blood glucose level of alloxan-induced diabetic mice on days 5, 10 and 15 compared to diab...
The association between diet, age, gender, socioeconomic status, ethnicity and hypertension are w... more The association between diet, age, gender, socioeconomic status, ethnicity and hypertension are well recognized among developing countries. However, the main factors causing hypertension in Pakistan are still not clear. Hypertension is complex and multi factorial. The current article summarizes some of the known factors responsible for hypertension within populated cities of Pakistan. This review was focused on ethnic group of people living within country. Random or multistage screening, socioeconomic status or hypertensive condition was considered during selection of subjects. The dietary patterns in relation with hypertension and other health problems were studied. Studies showed a prominent occurrence among urban adults, particularly women. The Diet transition towards the DASH Diet has been attributed to lower blood pressures. This review highlights the fact that dietary pattern, socioeconomic status, gender, age and obesity is associated with hypertension.
Molybdenum (Mo) is the most commonly used material as back contact in thin-film solar cells. Adhe... more Molybdenum (Mo) is the most commonly used material as back contact in thin-film solar cells. Adhesion of Mo film to soda-lime glass (SLG) substrate is crucial to the performance of solar cells. In this study, an optimized bilayer structure made of a thin layer of Mo on an ultra-thin chromium (Cr) adhesion layer is used as the back contact for a copper zinc tin sulfide (CZTS) thin-film solar cell on a SLG substrate. DC magnetron sputtering is used for deposition of Mo and Cr films. The conductivity of Mo/Cr bilayer films, their microstructure and surface morphology are studied at different deposition powers and working pressures. Good adhesion to the SLG substrate has been achieved by means of an ultra-thin Cr layer under the Mo layer. By optimizing the deposition conditions we achieved low surface roughness, high optical reflectance and low sheet resistivity while we could decrease the back contact thickness to 600 nm. That is two thirds to half of the thickness that is currently be...
This work demonstrates the effect of oxygen vacancy of SnOx thin films on the performance of pero... more This work demonstrates the effect of oxygen vacancy of SnOx thin films on the performance of perovskite solar cells. Various SnOx films with different amount of oxygen vacancy were deposited by sputtering at different substrate temperatures (25-300 ºC). The transmittance of the films decreases from 82% to 66% with increasing the deposition temperature from 25 ºC to 300 ºC. Both XPS and ESR have confirmed that higher density of oxygen vacancies were created within the SnOx film at high substrate temperature, which caused narrowing of the SnOx bandgap from 4.1 eV (25 ºC) to 3.74 eV (250 ºC). Combined measurements of UPS and UV-VIS spectroscopy have shown an excellent conduction band position alignment between the methylammonium lead iodide perovskite layer (3.90 eV) and the SnOx electron transport layer deposited at 250 ºC (3.92 eV). As a result, a significant enhancement of Voc from 0.82 V to 1.0 V was achieved, resulting in an increase of power conversion efficiency of the perovskit...
Hypertension (HTN) is considered one of the most important and well-established reasons for cardi... more Hypertension (HTN) is considered one of the most important and well-established reasons for cardiovascular abnormalities, strokes, and premature mortality globally. This study was designed to explore possible differentially expressed genes (DEGs) that contribute to the pathophysiology of hypertension. To identify the DEGs of HTN, we investigated 22 publicly available cDNA Affymetrix datasets using an integrated system-level framework. Gene Ontology (GO), pathway enrichment, and transcriptional factors were analyzed to reveal biological information. From 50 DEGs, we ranked 7 hypertension-related genes (p-value < 0.05): ADM, ANGPTL4, USP8, EDN, NFIL3, MSR1, and CEBPD. The enriched terms revealed significant functional roles of HIF-1-α transcription; endothelin; GPCR-binding ligand; and signaling pathways of EGF, PIk3, and ARF6. SP1 (66.7%), KLF7 (33.3%), and STAT1 (16.7%) are transcriptional factors associated with the regulatory mechanism. The expression profiles of these DEGs as ...
Purpose: To investigate Heliotropium strigosum whole plant extract for its potential to reduce th... more Purpose: To investigate Heliotropium strigosum whole plant extract for its potential to reduce the blood glucose level of alloxan-induced diabetic mice.Methods: Preliminary phytochemical analysis was carried out using standard procedures. Diabetes was induced in Balb/c mice by injecting alloxan (200 mg/kg i.p.). The crude methanol extract of Heliotropium strigosum (Hs.Cr, 30, 100 and 300 mg/kg doses) was administered daily to alloxan-induced diabetic mice for 15 days and its effect on fasting blood glucose levels, body weight and oral glucose tolerancewas evaluated. Two control groups (non-diabetic control and diabetic control) received normal saline (0.2 ml). Metformin (500 mg/kg) was used as reference standard.Results: Heliotropium strigosum showed positive for the presence of alkaloids, tannins and flavonoids. The extract (30, 100 and 300 mg/kg) caused significant reduction in the fasting blood glucose level of alloxan-induced diabetic mice on days 5, 10 and 15 compared to diab...
The association between diet, age, gender, socioeconomic status, ethnicity and hypertension are w... more The association between diet, age, gender, socioeconomic status, ethnicity and hypertension are well recognized among developing countries. However, the main factors causing hypertension in Pakistan are still not clear. Hypertension is complex and multi factorial. The current article summarizes some of the known factors responsible for hypertension within populated cities of Pakistan. This review was focused on ethnic group of people living within country. Random or multistage screening, socioeconomic status or hypertensive condition was considered during selection of subjects. The dietary patterns in relation with hypertension and other health problems were studied. Studies showed a prominent occurrence among urban adults, particularly women. The Diet transition towards the DASH Diet has been attributed to lower blood pressures. This review highlights the fact that dietary pattern, socioeconomic status, gender, age and obesity is associated with hypertension.
Molybdenum (Mo) is the most commonly used material as back contact in thin-film solar cells. Adhe... more Molybdenum (Mo) is the most commonly used material as back contact in thin-film solar cells. Adhesion of Mo film to soda-lime glass (SLG) substrate is crucial to the performance of solar cells. In this study, an optimized bilayer structure made of a thin layer of Mo on an ultra-thin chromium (Cr) adhesion layer is used as the back contact for a copper zinc tin sulfide (CZTS) thin-film solar cell on a SLG substrate. DC magnetron sputtering is used for deposition of Mo and Cr films. The conductivity of Mo/Cr bilayer films, their microstructure and surface morphology are studied at different deposition powers and working pressures. Good adhesion to the SLG substrate has been achieved by means of an ultra-thin Cr layer under the Mo layer. By optimizing the deposition conditions we achieved low surface roughness, high optical reflectance and low sheet resistivity while we could decrease the back contact thickness to 600 nm. That is two thirds to half of the thickness that is currently be...
This work demonstrates the effect of oxygen vacancy of SnOx thin films on the performance of pero... more This work demonstrates the effect of oxygen vacancy of SnOx thin films on the performance of perovskite solar cells. Various SnOx films with different amount of oxygen vacancy were deposited by sputtering at different substrate temperatures (25-300 ºC). The transmittance of the films decreases from 82% to 66% with increasing the deposition temperature from 25 ºC to 300 ºC. Both XPS and ESR have confirmed that higher density of oxygen vacancies were created within the SnOx film at high substrate temperature, which caused narrowing of the SnOx bandgap from 4.1 eV (25 ºC) to 3.74 eV (250 ºC). Combined measurements of UPS and UV-VIS spectroscopy have shown an excellent conduction band position alignment between the methylammonium lead iodide perovskite layer (3.90 eV) and the SnOx electron transport layer deposited at 250 ºC (3.92 eV). As a result, a significant enhancement of Voc from 0.82 V to 1.0 V was achieved, resulting in an increase of power conversion efficiency of the perovskit...
Hypertension (HTN) is considered one of the most important and well-established reasons for cardi... more Hypertension (HTN) is considered one of the most important and well-established reasons for cardiovascular abnormalities, strokes, and premature mortality globally. This study was designed to explore possible differentially expressed genes (DEGs) that contribute to the pathophysiology of hypertension. To identify the DEGs of HTN, we investigated 22 publicly available cDNA Affymetrix datasets using an integrated system-level framework. Gene Ontology (GO), pathway enrichment, and transcriptional factors were analyzed to reveal biological information. From 50 DEGs, we ranked 7 hypertension-related genes (p-value < 0.05): ADM, ANGPTL4, USP8, EDN, NFIL3, MSR1, and CEBPD. The enriched terms revealed significant functional roles of HIF-1-α transcription; endothelin; GPCR-binding ligand; and signaling pathways of EGF, PIk3, and ARF6. SP1 (66.7%), KLF7 (33.3%), and STAT1 (16.7%) are transcriptional factors associated with the regulatory mechanism. The expression profiles of these DEGs as ...
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Papers by Fawad Ali