Cet ouvrage retrace l'histoire du cyclotron Medicyc, ce pionnier relativement méconnu de la p... more Cet ouvrage retrace l'histoire du cyclotron Medicyc, ce pionnier relativement méconnu de la protonthérapie en France qui permit à Nice le premier traitement d'un mélanome de l'oeil au centre Antoine Lacassagne. Fruit d'une étroite collaboration entre l'ingénieur et le médecin et, dès l'origine, dévolu à la radiothérapie des tumeurs et à la production de radio-isotopes médicaux. Aujourd'hui, quelques vingt-cinq ans plus tard, cette protonthérapie connaît un essor considérable dans le monde
PURPOSE To describe the distribution of tumoral-reduced folates in cancer patients and to analyze... more PURPOSE To describe the distribution of tumoral-reduced folates in cancer patients and to analyze the link between this parameter and antitumor efficacy of fluorouracil (FU)-based induction chemotherapy. PATIENTS AND METHODS Ninety-five patients with head and neck squamous cell carcinoma were included in the present study and 41 received induction treatment with FU-based chemotherapy (35 men and six women; mean age, 59 years; range, 40 to 76). Thymidylate synthase (TS) activity was measured according to the tritium-release assay. Reduced folates (5-10 methylenetetrahydrofolate [CH2FH4] plus tetrahydrofolate) were measured according to the entrapment assay. RESULTS Among the whole group of patients, reduced folates ranged from nondetectable (< 0.3) to 17.7 pmol/mg protein; CH2FH4 ranged from nondetectable (< 0.3) to 8.2 pmol/mg protein. There was no significant link between tumoral levels of reduced folates and the severity of disease stage. Among 41 treated patients, there wer...
Revue de stomatologie et de chirurgie maxillo-faciale, 1991
Postirradiation sarcoma of the head and neck has rarely been reported. A case of malignant fibrou... more Postirradiation sarcoma of the head and neck has rarely been reported. A case of malignant fibrous histiocytoma (M.F.H.) occurring in the mandible is presented. Head and neck region was previously irradiated for Hodgkin's disease. The interval from initial radiation to diagnosis of sarcoma was 10 years. Aggressive treatment with early radical excision is the treatment of choice. In spite of extensive surgery, the patient died one year after treatment with local recurrence.
Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris, 2003
This study reviews a rare and poorly understood anatomic anomaly of the thyroid region: non-recur... more This study reviews a rare and poorly understood anatomic anomaly of the thyroid region: non-recurrence of the inferior laryngeal nerve. We describe thirteen cases of non-recurrence of the laryngeal nerve observed during 2128 surgical procedures on the thyroid gland. The malformation was right-sided in all thirteen patients (11 women, 2 men) and occurred at a frequency of 0.4% of all of the nerves explored. Only two complications were noted in this series of 13 cases: one case of temporary paresis and one case of irreversible vocal cord paralysis. A rare although not exceptional occurrence, non-recurrence of the inferior laryngeal nerve is an anomaly that Head and Neck surgeons should be familiar with so as to avoid nerve damage that can result in irreversible vocal cord paralysis.
Transposition of greater omentum (G.O.) from the abdominal cavity to repair sequelae of combined ... more Transposition of greater omentum (G.O.) from the abdominal cavity to repair sequelae of combined surgical and radiotherapeutic treatment of cancer in four cases has been presented. One axillary radionecrosis and three oropharyngostomas developed after extensive reconstructive surgery following radiotherapy. The theoretical possibilities for using this method are developed by reviewing the attributes of the G.O. (anti-infectious, immune, and trophic). The technical aspects of lengthening it in order to reach the neck, armpit or scalp are then analyzed. Favorable results agree with the use of G.O. in other domains. (auth)
RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 1982
The authors present four observations of rare localizations of non-Hodgkin lymphomas (3 cases of ... more The authors present four observations of rare localizations of non-Hodgkin lymphomas (3 cases of lymphoma of the thyroid, 1 case of lymphoma of the parotid), all of which were studied by echography. In two of the thyroid localizations, the echographic pattern was identical to that observed for nodes in non-Hodgkin lymphomas, and thus differs from that of cysts and necrotized or cystic tumors. In the one case of secondary lymphoma of the thyroid, accompanied by diffuse enlargement of the gland but no histological proof, echography revealed only diffuse enlargement, without any anomaly in the echostructure. In the one case of lymphoma of the parotid, the echographic image was similar to that of a lymphomatous node, but it cannot be formally differentiated from the structure which can be observed for a mixed tumor or a cystic lymphangioma.
Liver metastases from head and neck cancer are rare (4.4%) and associated with a poor prognosis (... more Liver metastases from head and neck cancer are rare (4.4%) and associated with a poor prognosis (median survival 4 months). The objective of the present study was to evaluate the radiological and biological features of liver metastases from head and neck (H and N) squamous cell carcinomas in 24 patients among 550 recurrent H and N cancer patients in our data bank. At first presentation of liver nodules, liver enzyme levels (LEL) were found to be abnormal in 46% of patients (n = 11). Ultrasound features included miscellaneous presentations such as hypoechogenic (n = 21), hyperechogenic hemangioma-like lesions (n = 2), owl&#39;s eye (n = 2) or cyst-like liver nodules (n = 3). Hepatomegaly was present in 48% of the cases without any sign of portal hypertension and without any ascites. 1 month before death, all patients presented with abnormal LEL. Liver imaging showed an increase of 1.8x in size and of 2x in number of the tumor nodules. Hepatomegaly was present in 54%. Little ascites appeared in 2 cases, with no evidence of portal hypertension or liver insufficiency. Median disease-free interval and overall survival from recurrence were 10.8 and 4 months, respectively. Ultrasound is convenient, cheap, without any side effect, and can provide additional information about liver metastases in H and N cancer patients. In patients with a history of H and N carcinoma ultrasound should be used to screen for isolated hepatic nodules even in the presence of normal liver function and if LDH elevation should be the only biological sign of alert.
Background: Despite its high response rate, the use of neoadjuvant chemotherapy remains controver... more Background: Despite its high response rate, the use of neoadjuvant chemotherapy remains controversial. Pretherapeutic identification of subgroups of patients who are likely to respond to chemotherapy is of the utmost importance.Purpose: In this study, we have attempted to determine the relationship between specific radiological parameters and the response to neoadjuvant chemotherapy. In addition, we have determined if these parameters could
A propos de 223 cas de thyroidectomies subtotales pour goitre multi-nodulaire realisees entre 198... more A propos de 223 cas de thyroidectomies subtotales pour goitre multi-nodulaire realisees entre 1980 et 1985, les auteurs font le point sur cette technique et discutent de sa place dans le traitement des affections pluri-nodulaires de la glande thyroide. L'indication operatoire repose sur les risques evolutifs de cette affection qui sont multiples. La thyroidectomie subtotale extra-capsulaire dont les principes technqiues sont rappeles donne une grande securite sur les nerfs recurrents. Elle s'accompagne d'un risque d'hypoparathyroidie post-operatoire qui doit etre reduit par le reperage des glandes parathyroides et la preservation de leur vascularisation ou par leur autotransplantation si elles sont devascularisees
Cet ouvrage retrace l'histoire du cyclotron Medicyc, ce pionnier relativement méconnu de la p... more Cet ouvrage retrace l'histoire du cyclotron Medicyc, ce pionnier relativement méconnu de la protonthérapie en France qui permit à Nice le premier traitement d'un mélanome de l'oeil au centre Antoine Lacassagne. Fruit d'une étroite collaboration entre l'ingénieur et le médecin et, dès l'origine, dévolu à la radiothérapie des tumeurs et à la production de radio-isotopes médicaux. Aujourd'hui, quelques vingt-cinq ans plus tard, cette protonthérapie connaît un essor considérable dans le monde
PURPOSE To describe the distribution of tumoral-reduced folates in cancer patients and to analyze... more PURPOSE To describe the distribution of tumoral-reduced folates in cancer patients and to analyze the link between this parameter and antitumor efficacy of fluorouracil (FU)-based induction chemotherapy. PATIENTS AND METHODS Ninety-five patients with head and neck squamous cell carcinoma were included in the present study and 41 received induction treatment with FU-based chemotherapy (35 men and six women; mean age, 59 years; range, 40 to 76). Thymidylate synthase (TS) activity was measured according to the tritium-release assay. Reduced folates (5-10 methylenetetrahydrofolate [CH2FH4] plus tetrahydrofolate) were measured according to the entrapment assay. RESULTS Among the whole group of patients, reduced folates ranged from nondetectable (< 0.3) to 17.7 pmol/mg protein; CH2FH4 ranged from nondetectable (< 0.3) to 8.2 pmol/mg protein. There was no significant link between tumoral levels of reduced folates and the severity of disease stage. Among 41 treated patients, there wer...
Revue de stomatologie et de chirurgie maxillo-faciale, 1991
Postirradiation sarcoma of the head and neck has rarely been reported. A case of malignant fibrou... more Postirradiation sarcoma of the head and neck has rarely been reported. A case of malignant fibrous histiocytoma (M.F.H.) occurring in the mandible is presented. Head and neck region was previously irradiated for Hodgkin's disease. The interval from initial radiation to diagnosis of sarcoma was 10 years. Aggressive treatment with early radical excision is the treatment of choice. In spite of extensive surgery, the patient died one year after treatment with local recurrence.
Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris, 2003
This study reviews a rare and poorly understood anatomic anomaly of the thyroid region: non-recur... more This study reviews a rare and poorly understood anatomic anomaly of the thyroid region: non-recurrence of the inferior laryngeal nerve. We describe thirteen cases of non-recurrence of the laryngeal nerve observed during 2128 surgical procedures on the thyroid gland. The malformation was right-sided in all thirteen patients (11 women, 2 men) and occurred at a frequency of 0.4% of all of the nerves explored. Only two complications were noted in this series of 13 cases: one case of temporary paresis and one case of irreversible vocal cord paralysis. A rare although not exceptional occurrence, non-recurrence of the inferior laryngeal nerve is an anomaly that Head and Neck surgeons should be familiar with so as to avoid nerve damage that can result in irreversible vocal cord paralysis.
Transposition of greater omentum (G.O.) from the abdominal cavity to repair sequelae of combined ... more Transposition of greater omentum (G.O.) from the abdominal cavity to repair sequelae of combined surgical and radiotherapeutic treatment of cancer in four cases has been presented. One axillary radionecrosis and three oropharyngostomas developed after extensive reconstructive surgery following radiotherapy. The theoretical possibilities for using this method are developed by reviewing the attributes of the G.O. (anti-infectious, immune, and trophic). The technical aspects of lengthening it in order to reach the neck, armpit or scalp are then analyzed. Favorable results agree with the use of G.O. in other domains. (auth)
RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 1982
The authors present four observations of rare localizations of non-Hodgkin lymphomas (3 cases of ... more The authors present four observations of rare localizations of non-Hodgkin lymphomas (3 cases of lymphoma of the thyroid, 1 case of lymphoma of the parotid), all of which were studied by echography. In two of the thyroid localizations, the echographic pattern was identical to that observed for nodes in non-Hodgkin lymphomas, and thus differs from that of cysts and necrotized or cystic tumors. In the one case of secondary lymphoma of the thyroid, accompanied by diffuse enlargement of the gland but no histological proof, echography revealed only diffuse enlargement, without any anomaly in the echostructure. In the one case of lymphoma of the parotid, the echographic image was similar to that of a lymphomatous node, but it cannot be formally differentiated from the structure which can be observed for a mixed tumor or a cystic lymphangioma.
Liver metastases from head and neck cancer are rare (4.4%) and associated with a poor prognosis (... more Liver metastases from head and neck cancer are rare (4.4%) and associated with a poor prognosis (median survival 4 months). The objective of the present study was to evaluate the radiological and biological features of liver metastases from head and neck (H and N) squamous cell carcinomas in 24 patients among 550 recurrent H and N cancer patients in our data bank. At first presentation of liver nodules, liver enzyme levels (LEL) were found to be abnormal in 46% of patients (n = 11). Ultrasound features included miscellaneous presentations such as hypoechogenic (n = 21), hyperechogenic hemangioma-like lesions (n = 2), owl&#39;s eye (n = 2) or cyst-like liver nodules (n = 3). Hepatomegaly was present in 48% of the cases without any sign of portal hypertension and without any ascites. 1 month before death, all patients presented with abnormal LEL. Liver imaging showed an increase of 1.8x in size and of 2x in number of the tumor nodules. Hepatomegaly was present in 54%. Little ascites appeared in 2 cases, with no evidence of portal hypertension or liver insufficiency. Median disease-free interval and overall survival from recurrence were 10.8 and 4 months, respectively. Ultrasound is convenient, cheap, without any side effect, and can provide additional information about liver metastases in H and N cancer patients. In patients with a history of H and N carcinoma ultrasound should be used to screen for isolated hepatic nodules even in the presence of normal liver function and if LDH elevation should be the only biological sign of alert.
Background: Despite its high response rate, the use of neoadjuvant chemotherapy remains controver... more Background: Despite its high response rate, the use of neoadjuvant chemotherapy remains controversial. Pretherapeutic identification of subgroups of patients who are likely to respond to chemotherapy is of the utmost importance.Purpose: In this study, we have attempted to determine the relationship between specific radiological parameters and the response to neoadjuvant chemotherapy. In addition, we have determined if these parameters could
A propos de 223 cas de thyroidectomies subtotales pour goitre multi-nodulaire realisees entre 198... more A propos de 223 cas de thyroidectomies subtotales pour goitre multi-nodulaire realisees entre 1980 et 1985, les auteurs font le point sur cette technique et discutent de sa place dans le traitement des affections pluri-nodulaires de la glande thyroide. L'indication operatoire repose sur les risques evolutifs de cette affection qui sont multiples. La thyroidectomie subtotale extra-capsulaire dont les principes technqiues sont rappeles donne une grande securite sur les nerfs recurrents. Elle s'accompagne d'un risque d'hypoparathyroidie post-operatoire qui doit etre reduit par le reperage des glandes parathyroides et la preservation de leur vascularisation ou par leur autotransplantation si elles sont devascularisees
Uploads