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Maltose-functional metal–organic framework assisted laser desorption/ionization mass spectrometry for small biomolecule determination 

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Abstract

A series of functional metal–organic frameworks (MOFs) were facilely prepared through an one-pot procedure or post-synthetic modification strategy and used as matrices in laser desorption ionization mass spectrometry (LDI-MS). Compared with traditional organic matrices and other MOFs, maltose-functional MOF MIL-101-maltose demonstrated ultrahigh ionization efficiency, free matrix background, uniform crystallization, and good dispersibility. A simple, general, and efficient LDI-MS platform was developed for rapid detection of various small biomolecules using MIL-101-maltose as matrix, providing several advantages including low sample consumption of 500 nL, short analysis time of few seconds, strong salt tolerance (500 mM NaCl), and satisfactory reproducibility. The MIL-101-maltose matrix was used for serum glucose determination and successfully distinguished the diabetic patients from the healthy controls. This work provides a generic LDI-MS platform for fast determination of small biomolecules with high potential in clinical diagnosis and disease monitoring.

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Acknowledgements

We thank Dr. Liqing Wu for providing MS instrumental assistance.

Funding

This work was supported by the National Natural Science Foundation of China (Grant No. 22004004 and 21804123), and Beijing Key Laboratory of Mental Disorders, Code: 2021JSJB02.

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Authors and Affiliations

  1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China

    Wen Ma & Jun Li

  2. Key Laboratory of Chemical Metrology and Applications On Nutrition and Health for State Market Regulation, Division of Metrology in Chemistry, National Institute of Metrology, Beijing, 100029, China

    Bingxin Yang & Xianjiang Li

  3. The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, 100088, China

    Mingxia Liu

  4. Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China

    Huwei Liu

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  1. Wen Ma
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Correspondence to Wen Ma or Xianjiang Li.

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Ma, W., Yang, B., Li, J. et al. Maltose-functional metal–organic framework assisted laser desorption/ionization mass spectrometry for small biomolecule determination . Microchim Acta 189, 253 (2022). https://doi.org/10.1007/s00604-022-05338-x

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