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Serum Proteomics Identified TAFI as a Potential Molecule Facilitating the Migration of Peripheral Monocytes to Damaged White Matter During Chronic Cerebral Hypoperfusion

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Abstract

Neuroinflammation is assumed as the critical pathophysiologic mechanism of white matter lesions (WMLs), and infiltrated peripheral monocyte-derived macrophages are implicated in the development of neuroinflammation. This study sought to explore the blood molecules that promote the migration of peripheral monocytes to the sites of WMLs. The serum protein expression profiles of patients and Sprague–Dawley rat models with WMLs were detected by data-independent acquisition (DIA) proteomics technique. Compared with corresponding control groups, we acquired 62 and 41 differentially expressed proteins (DEPs) in the serum of patients and model rats with WMLs respectively. Bioinformatics investigations demonstrated that these DEPs were linked to various Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways and Gene Ontology (GO) terms involved in neuroinflammation. Afterward, we identified thrombin-activatable fibrinolysis inhibitor (TAFI) as a shared and overexpressed protein in clinical and animal serum samples, which was further verified by enzyme-linked immunosorbent assay. Additionally, an upregulation of TAFI was also observed in the white matter of rat models, and the inhibition of TAFI impeded the migration of peripheral monocytes to the area of WMLs. In vitro experiments suggested that TAFI could enhance the migration ability of RAW264.7 cells and increase the expression of Ccr2. Our study demonstrates that neuroinflammatory signals can be detected in the peripheral blood of WMLs patients and model rats. TAFI may serve as a potential protein that promotes the migration of peripheral monocytes to WMLs regions, thereby providing a novel molecular target for further investigation into the interaction between the central and peripheral immune systems.

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Data Availability

The datasets presented in this study can be found in online repositories. The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium (http://proteomecentral.proteomexchange.org) via the iProX partner repository with the dataset identifier PXD041288 (The data will be made publicly accessible upon acceptance of this article for publication).

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Acknowledgements

Not applicable.

Funding

This study was supported by funds from the National Natural Science Foundation of China, China (Grant No. 82171334), the Chongqing Science and Health Joint Medical Research Project, China (Grant No. 2023ZDXM016) and the Individualized training program for the excellent talent pool of the Army Medical University.

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  1. Yuhan Wang, Wenchao Cheng, and Xiuying Chen have contributed equally to this work.

Authors and Affiliations

  1. Department of Neurology, Xinqiao Hospital, The Army Medical University (Third Military Medical University), Chongqing, China

    Yuhan Wang, Wenchao Cheng, Chang Cheng, Lan Zhang & Wen Huang

  2. Department of Neurology, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing University, Chongqing, China

    Xiuying Chen & Wen Huang

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  1. Yuhan Wang
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Contributions

WH and YW made the study design. YW and WC organized the statistical analysis and wrote the manuscript. YW, WC, and XC performed the experiments. CC and LZ assisted some of the experiments. All authors contributed to manuscript revision and approved the final manuscript.

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Correspondence to Wen Huang.

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The study was conducted in accordance with the Declaration of Helsinki, and the protocol was approved by the Medical Ethics Committee of Second Affiliated Hospital (Xinqiao Hospital) of Army Medical University and the Laboratory Animal Welfare and Ethics Committee of Army Medical University.

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Wang, Y., Cheng, W., Chen, X. et al. Serum Proteomics Identified TAFI as a Potential Molecule Facilitating the Migration of Peripheral Monocytes to Damaged White Matter During Chronic Cerebral Hypoperfusion. Neurochem Res 49, 597–616 (2024). https://doi.org/10.1007/s11064-023-04050-3

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  • DOI: https://doi.org/10.1007/s11064-023-04050-3

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