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Design and therapeutic application of sodium alginate-based hydrogel with biodegradability and catalytic activity

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Abstract

How to efficiently treat cancer in a minimally invasive manner has become one of the major focuses of recent developments in biomedicine. In this research, biodegradable sodium alginate (SA) hydrogel encapsulated with NaHCO3 and glucose oxidase (GOX) was synthesized using Fe3+ as the crosslinker for the tumor chemodynamic therapy (CDT) and starvation therapy (ST). Material safety assessments revealed that this hydrogel possesses good in vitro and in vivo security. In tumor microenvrionment (TME), the Fe3+ further reacted with the intracellular glutathione and was transformed into Fe2+, which triggered the Fenton reaction with the H2O2 within TME and produced abundant highly toxic ·OH (hydroxyl radicals) for efficient tumor CDT. Furthermore, the GOX catalyzed the enzymolysis of glucose to consume the nutrient of the tumor and enhance the H2O2 level in TME. Besides, the CO2 bubbles that were generated from the decomposing of NaHCO3 promoted the contact between glucose and GOX. Findings in this research would have important implications for the present status of tumor therapy.

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Author notes

  1. These authors contributed equally to this work.

Authors and Affiliations

  1. College of Science, University of Shanghai for Science and Technology, Shanghai, 200093, China

    JinFeng Li, YongKang Chen, YuTing Zheng, LingLing Zhou, JiaYan Zhao, YiYun Liu & ShiGe Wang

  2. Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, 222300, China

    JiuLong Zhao

  3. State Key Laboratory of New Textile Materials and Advanced Processing Technologies, Wuhan Textile University, Wuhan, 430073, China

    XiuYing Liu

Authors
  1. JinFeng Li
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  2. JiuLong Zhao
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Corresponding authors

Correspondence to XiuYing Liu or ShiGe Wang.

Additional information

This work was supported by the National Natural Science Foundation of China (Grant Nos. 51702214 and 81972904), the Key Program for Basic Research of Shanghai (Grant No. 19JC1415600), and the Natural Science Foundation of Hubei Province (Grant No. 2019CFC916).

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The supporting information is available online at tech.scichina.com and link.springer.com. The supporting materials are published as submitted, without typesetting or editing. The responsibility for scientific accuracy and content remains entirely with the authors.

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Li, J., Zhao, J., Chen, Y. et al. Design and therapeutic application of sodium alginate-based hydrogel with biodegradability and catalytic activity. Sci. China Technol. Sci. 63, 2403–2412 (2020). https://doi.org/10.1007/s11431-020-1623-8

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  • DOI: https://doi.org/10.1007/s11431-020-1623-8

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