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RETRACTED ARTICLE: Norcantharidin modulates miR-655-regulated SENP6 protein translation to suppresses invasion of glioblastoma cells

  • Original Article
  • Published:
Tumor Biology

This article was retracted on 20 April 2017

Abstract

Norcantharidin (NCTD) is currently used as an anticancer drug for the treatment of some malignant cancers. However, whether it may have therapeutic effects on glioblastoma multiforme (GBM) remains unknown. Moreover, the underlying mechanisms have not been completely elucidated. Recently, SUMO-specific protease 6 (SENP6) has been shown as a tumor suppressor in some cancers. Nevertheless, whether it is involved in the pathogenesis of GBM has not been examined. Here, we studied the effects of NCTD on GBM cells. We found that NCTD dose-dependently increased SENP6 protein, but not messenger RNA (mRNA), in GBM cells, resulting in the suppression of cell invasion. Depletion of SENP6 in GBM cells significantly attenuated the NCTD-induced suppression of GBM cell invasion, while overexpression of SENP6 in GBM cells mimicked the effects of NCTD on cell invasion. Moreover, NCTD dose-dependently decreased the levels of microRNA-655 (miR-655), which bound to 3′-UTR of SENP6 mRNA to inhibit its translation. Overexpression of miR-655 decreased SENP6 in GBM cells, while depletion of miR-655 increased SENP6 protein in GBM cells. Taken together, our data demonstrates a previously unappreciated control of NCTD to suppress GBM cell invasion through modulation of miR-655-regulated SENP6 protein translation.

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Acknowledgments

This work has been supported by the Program for Excellent Talents in Liaoning Province in China (NO. LJQ2013088).

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Authors and Affiliations

  1. Department of Neurosurgery, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, 121001, China

    Zhenxing Zhang, Xu Feng, Ye Miao, Honglei Wang & Yang Li

  2. Department of Histology and Embryology, Liaoning Medical University, 3-40 Songpo Road, Jinzhou, 121001, China

    Xiaofeng Song & He Tian

Authors
  1. Zhenxing Zhang
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  2. Xiaofeng Song
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  3. Xu Feng
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  4. Ye Miao
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  5. Honglei Wang
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  6. Yang Li
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Corresponding author

Correspondence to Xiaofeng Song.

Ethics declarations

All experiments were carried out in strict accordance with the regulations of the Guide for experimental research issued by Liaoning Medical University. The protocol was approved by the Institutional Animal Care and Use Committee of the Liaoning Medical University.

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None.

Additional information

The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

An erratum to this article is available at http://dx.doi.org/10.1007/s13277-017-5487-6.

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Zhang, Z., Song, X., Feng, X. et al. RETRACTED ARTICLE: Norcantharidin modulates miR-655-regulated SENP6 protein translation to suppresses invasion of glioblastoma cells. Tumor Biol. 37, 15635–15641 (2016). https://doi.org/10.1007/s13277-015-4447-2

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  • DOI: https://doi.org/10.1007/s13277-015-4447-2

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