Abstract
A comparative analysis of olignucleotide frequencies in two sets of introns of genes highly-transcribed and lowly-transcribed respectively has suggested that the existence of potential positive regulatory motifs of transcription in yeast introns. To further reveal the distribution feature of these motifs, we detected significant clusters of these motifs (mainly pentanucleotides) in introns by r-scan analysis. The results showed that there are more clusters of regulatory motifs in the introns of ribosomal protein genes (highly-transcribed genes) than in lowly-transcribed introns. Experimental studies show that the transcription factors function cooperatively in transcriptional activation and the corresponding binding sites for factors generally cluster in DNA. Accordingly, we speculated that the cluster distribution of regulatory motifs of transcription in yeast introns could becorrelated with the cooperative action of transcription factors and the transcriptional rates of genes could be improved by the cooperativity.
This work wa s supported by grants from The National Natural Science foundation of China (no.30360027).
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Hu, J., Zhang, J. (2005). The Cluster Distribution of Regulatory Motifs of Transcription in Yeast Introns. In: Huang, DS., Zhang, XP., Huang, GB. (eds) Advances in Intelligent Computing. ICIC 2005. Lecture Notes in Computer Science, vol 3645. Springer, Berlin, Heidelberg. https://doi.org/10.1007/11538356_6
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DOI: https://doi.org/10.1007/11538356_6
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