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Magnetic Resonance Imaging of Neuroinflammation

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Imaging Inflammation

Part of the book series: Progress in Inflammation Research ((PIR,volume 91))

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Abstract

Magnetic resonance imaging is a powerful tool in preclinical research of diseases with associated neuroinflammation, as it allows high-resolution imaging without harmful ionizing radiation. The development of targetable iron oxide contrast agents, such as microparticles of iron oxide (MPIO), has greatly enhanced molecular MRI for superior detection of target molecules. Cell adhesion molecules (CAMs) are upregulated early in neuroinflammation on the luminal side of activated endothelial cells within the blood-brain barrier, making them a highly accessible target. Targeting MPIO with CAM antibodies has improved the early detection of neuropathologies in preclinical models, as well as providing further insight into disease progression and mechanisms. This chapter highlights the uses of molecular MRI, specifically CAM-targeted MPIO, for investigating multiple sclerosis, stroke, epilepsy, and brain cancer and how the advances made in these preclinical models have the potential to be transferred to other neuropathologies and tissues.

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Authors and Affiliations

  1. Department of Oncology, University of Oxford, Radiobiology Research Institute, Churchill Hospital, Oxford, UK

    Vanessa A. Johanssen & Nicola R. Sibson

  2. Astellas Pharma Canada, Markham, ON, Canada

    Niloufar Zarghami

Authors
  1. Vanessa A. Johanssen
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  2. Niloufar Zarghami
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  3. Nicola R. Sibson
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Correspondence to Nicola R. Sibson .

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Editors and Affiliations

  1. Institute of Pharmaceutical Science, King#x2019;s College London, London, UK

    Francis Man

  2. Department of Medicine, University of California, San Francisco, San Francisco, CA, USA

    Simon J. Cleary

Ethics declarations

Funding: The authors of this chapter were funded by the Medical Research Council (MR/V005995/1), Cancer Research UK (C5255/A15935), the CRUK & EPSRC Cancer Imaging Centre in Oxford (C5255/A16466), and a Radcliffe Scholarship from the University College, Oxford, UK.

Conflict of Interest: The authors have no conflicts of interest to declare.

Ethical approval: All animal experiments were approved by the University of Oxford Clinical Medicine Ethics Review Committee and the UK Home Office (Animals [Scientific Procedures] Act 1986) and conducted in accordance with the University of Oxford Policy on the Use of Animals in Scientific Research, the ARRIVE Guidelines, and Guidelines for the Welfare and Use of Animals in Cancer Research (Workman et al. Guidelines for the welfare and use of animals in cancer research. British Journal of Cancer 2010; 1555–1557).

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Johanssen, V.A., Zarghami, N., Sibson, N.R. (2023). Magnetic Resonance Imaging of Neuroinflammation. In: Man, F., Cleary, S.J. (eds) Imaging Inflammation. Progress in Inflammation Research, vol 91. Springer, Cham. https://doi.org/10.1007/978-3-031-23661-7_3

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