Abstract
Electrical pulses were applied to the distal femur of rabbits by inserting four electrodes in order to evaluate if and to what extent cell electroporation could be achieved in such a non-homogenous tissue. Dose response effect of number of pulses delivered was observed. 120 pulses at 1750V/cm successfully removed all osteogenetic activity among the electrodes, as evidenced by tetracyclin staining. These preclinical results lay the foundation for use of electroporation in the treatment of bone metastases.
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© 2009 International Federation for Medical and Biological Engineering
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Cadossi, R., Fini, M., Ronchetti, M., De Terlizzi, F., Cavani, F. (2009). Electroporation of Bone Tissue: Implications for Use in the Treatment of Bone Metastasis with Electrochemotherapy. In: Dössel, O., Schlegel, W.C. (eds) World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany. IFMBE Proceedings, vol 25/13. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03895-2_3
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DOI: https://doi.org/10.1007/978-3-642-03895-2_3
Publisher Name: Springer, Berlin, Heidelberg
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Online ISBN: 978-3-642-03895-2
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