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In vivo high-resolution magnetic resonance elastography of the uterine corpus and cervix

  • Magnetic Resonance
  • Published:
European Radiology Aims and scope Submit manuscript

Abstract

Objectives

To apply 3D multifrequency MR elastography (3DMMRE) to the uterus and analyse the viscoelasticity of the uterine tissue in healthy volunteers considering individual variations and variations over the menstrual cycle.

Methods

Sixteen healthy volunteers participated in the study, one of whom was examined 12 times over two menstrual cycles. Pelvic 3DMMRE was performed on a 1.5-T scanner with seven vibration frequencies (30–60 Hz) using a piezoelectric driver. Two mechanical parameter maps were obtained corresponding to the magnitude (|G *|) and the phase angle (φ) of the complex shear modulus.

Results

On average, the uterine corpus had higher elasticity, but similar viscosity compared with the cervix, reflected by |G *|uterine corpus = 2.58 ± 0.52 kPa vs. |G *|cervix = 2.00 ± 0.34 kPa (p < 0.0001) and φ uterine corpus = 0.54 ± 0.08, φ cervix = 0.57 ± 0.12 (p = 0.428). With 2.23 ± 0.26 kPa, |G *| of the myometrium was lower in the secretory phase (SP) compared with that of the proliferative phase (PP, |G *| = 3.01 ± 0.26 kPa). For the endometrium, the value of |G *| in SP was 68 % lower than during PP (PP, |G *| = 3.34 ± 0.42 kPa; SP, |G *| = 1.97 ± 0.34 kPa; p = 0.0061).

Conclusion

3DMMRE produces high-resolution mechanical parameter maps of the uterus and cervix and shows sensitivity to structural and functional changes of the endometrium and myometrium during the menstrual cycle.

Key Points

• MR elastography provided for the first time spatially resolved viscoelasticity maps of uterus.

• Uterine corpus had a higher elasticity, but similar viscosity compared with cervix.

• The stiffness of both endometrium and myometrium decreases during the menstrual cycle.

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Acknowledgements

The scientific guarantor of this publication is Dr.Ingolf Sack. The authors of this manuscript declare relationships with the following companies: B.H. Financial activities related to the present article: Department of Radiology received grants from Abbott, Actelion Pharmaceuticals, Bayer Schering Pharma, Bayer Vital, Bracco Group, Bristol-Myers Squibb, Charité Research Organisation, Deutsche Krebshilfe, Dt. Stiftung für Herzforschung, Essex Pharma, EU Programmes, Fibrex Medical, Focused Ultrasound Surgery Foundation, Fraunhofer Gesellschaft, Guerbet, INC Research, InSightec Ltd, Ipsen Pharma, Kendle/MorphoSys, Lilly, Lundbeck, MeVis Medical Solutions, Nexus Oncology, Novartis, Parexel CRO Service, Perceptive, Pfizer, Philips, Sanofi Aventis, Siemens, Spectranetics, Terumo Medical, TNS Healthcare, Toshiba, UCB Pharma, Wyeth Pharma, and Zukunftsfond Berlin (TSB). Financial activities not related to the present article: Department of Radiology received grants from Abbott, Actelion Pharmaceuticals, Bayer Schering Pharma, Bayer Vital, Bracco Group, Bristol-Myers Squibb, Charité Research Organisation, Deutsche Krebshilfe, Dt. Stiftung für Herzforschung, Essex Pharma, EU Programmes, Fibrex Medical, Focused Ultrasound Surgery Foundation, Fraunhofer Gesellschaft, Guerbet, INC Research, InSightec, Ipsen Pharma, Kendle/MorphoSys, Lilly, Lundbeck, MeVis Medical Solutions, Nexus Oncology, Novartis, Parexel CRO Service, Perceptive, Pfizer, Philips, Sanofi Aventis, Siemens, Spectranetics, Terumo Medical, TNS Healthcare, Toshiba, UCB Pharma, Wyeth Pharma, Zukunftsfond Berlin (TSB). Other relationships: board memberships (Deutsche Röntgengesellschaft, European Congress of Radiology, European Society of Radiology, ESMRMB, European School of Radiology, Deutsche Forschungsgemeinschaft, support for travel); consultancy (Bayer Schering Pharma, Toshiba; honorarium); Abbott, Actelion Pharmaceuticals, Bayer Schering Pharma, Bayer Vital, Bracco Group, Bristol-Myers Squibb, Charité Research Organisation, Deutsche Krebshilfe, Dt. Stiftung für Herzforschung, Essex Pharma, EU Programmes, Fibrex Medical, Focused Ultrasound Surgery Foundation, Fraunhofer Gesellschaft, Guerbet, INC Research, InSightec, Ipsen Pharma, Kendle/MorphoSys, Lilly, Lundbeck, MeVis Medical Solutions, Nexus Oncology, Novartis, Parexel CRO Service, Perceptive, Pfizer, Philips, Sanofi Aventis, Siemens, Spectranetics, Terumo Medical, TNS Healthcare, Toshiba, UCB Pharma, Wyeth Pharma, Zukunftsfond Berlin (TSB), Amgen, AO Foundation, Bard, BBraun (Sponsoring eines Workshops), Boehring Ingelheimer, Bransgate, PPD (CRO), CELLACT Pharma, Celgene, CeloNova BioSciences, Covance, DC Devices Inc USA, Ganymed, Gilead Sciences, Glaxo Smith Kline, ICON (CRO), Jansen, LUX Biosciences, MedPass (CRO), Merck, Mologen, Nuvisan, Pluristem, Quintiles (CRO), Roche, Schumacher (sponsoring workshops), Seattle Genetics, Symphogen and TauRx Therapeutics. For the remaining authors none were declared. The authors state that this work has not received any funding. No complex statistical methods were necessary for this paper. Institutional review board approval was obtained. Written informed consent was obtained from all subjects (patients) in this study. No study subjects or cohorts have been previously reported. Methodology: prospective, experimental, performed at one institution.

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Authors and Affiliations

  1. Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, China

    Xuyuan Jiang

  2. Department of Radiology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany

    Patrick Asbach, Kaspar-Josche Streitberger, Bernd Hamm, Ingolf Sack & Jing Guo

  3. Departments of Gynecology and Obstetrics, Charité - Universitätsmedizin Berlin, Berlin, Germany

    Anke Thomas

  4. Department of Medical Informatics, Charité - Universitätsmedizin Berlin, Berlin, Germany

    Jürgen Braun

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  1. Xuyuan Jiang
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  3. Kaspar-Josche Streitberger
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Correspondence to Jing Guo.

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Jiang, X., Asbach, P., Streitberger, KJ. et al. In vivo high-resolution magnetic resonance elastography of the uterine corpus and cervix. Eur Radiol 24, 3025–3033 (2014). https://doi.org/10.1007/s00330-014-3305-8

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  • DOI: https://doi.org/10.1007/s00330-014-3305-8

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