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Study of poly(l-lactide) microparticles based on supercritical CO2

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Abstract

Poly(l-lactide) (PLLA) microparticles were prepared in supercritical anti-solvent process. The effects of several key factors on surface morphology, and particle size and particle size distribution were investigated. These factors included initial drops size, saturation ratio of PLLA solution, pressure, temperature, concentration of the organic solution, the flow rate of the solution and molecular weight of PLLA. The results indicated that the saturation ratio of PLLA solution, concentration of the organic solution and flow rate of the solution played important roles on the properties of products. Various microparticles with the mean particle size ranging from 0.64 to 6.64 μm, could be prepared by adjusting the operational parameters. Fine microparticles were obtained in a process namely solution-enhanced dispersion by supercritical fluids (SEDS) process with dichloromethane/acetone mixture as solution.

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Acknowledgement

Financial supports from the Fund for Excellent Youth Teachers of Education Ministry of China (2002123) are gratefully acknowledged.

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Authors and Affiliations

  1. College of Materials Science and Engineering, Sichuan University, Chengdu, 610064, Sichuan, China

    Ai-Zheng Chen, Xi-Ming Pu, Yun-Qing Kang, Li Liao, Ya-Dong Yao & Guang-Fu Yin

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  1. Ai-Zheng Chen
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  2. Xi-Ming Pu
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  3. Yun-Qing Kang
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  4. Li Liao
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  5. Ya-Dong Yao
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  6. Guang-Fu Yin
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Correspondence to Guang-Fu Yin.

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Chen, AZ., Pu, XM., Kang, YQ. et al. Study of poly(l-lactide) microparticles based on supercritical CO2 . J Mater Sci: Mater Med 18, 2339–2345 (2007). https://doi.org/10.1007/s10856-007-3173-8

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  • DOI: https://doi.org/10.1007/s10856-007-3173-8

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