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Oxygen supply/uptake mismatch during incremental stimulation of the human tibialis anterior

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Abstract

Background

Local oxygen supply/uptake mismatch (O2M) of active muscles may be influenced by the effectiveness of microvascular adaptations to metabolic demand. The aim of this work was to provide a novel, objective method to measure O2M through incremental stimulation.

Methods

The tibialis anterior of 20 subjects was electrically stimulated at the main motor point. The stimulation protocol involved five single twitches at maximal stimulus amplitude (Vmax = full motor unit recruitment) and five 90-s steps with increasing amplitude and frequency of the intermittent stimulation. Changes in force, oxygenated Hb (O2Hb) and deoxygenated Hb (HHb) were recorded. Contraction time (CT) of single twitches, fatigue index (FI) and O2M were calculated.

Results

F-statistics identified two groups of muscles, one with FI < 0.69 (group F, more fatiguable) and one with FI > 0.69 (group R, less fatiguable). Group R showed significantly lower CT, higher basal O2Hb, lower ΔHHb and lower O2M with respect to group F.

Conclusion

On the basis of the relationship between O2M and FI, the proposed method distinguished two different functional capacities of human TA muscles. This tool could be applied to estimate the kinetics of aerobic adaptation to increasing metabolic demand in muscles affected by myopathies or subjected to rehabilitation or training programmes.

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Authors and Affiliations

  1. Department of Biomedical Sciences and Biotechnologies, University of Brescia, Viale Europa 11, 25123, Brescia, Italy

    Caterina Neviani, Claudio Orizio & Massimiliano Gobbo

  2. Faculty of Exercise and Sport Science, University of Verona, Via F. Casorati 43, 37131, Verona, Italy

    Paolo Gaffurini

  3. Laboratory of Neuromuscular Rehabilitation (LaRiN) established thanks to the University of Brescia and the Institute “Casa di Cura Domus Salutis” cooperation, Institute “Domus Salutis”, Via Lazzaretto 3, 25123, Brescia, Italy

    Paolo Gaffurini, Claudio Orizio & Massimiliano Gobbo

Authors
  1. Paolo Gaffurini
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  2. Caterina Neviani
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  3. Claudio Orizio
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  4. Massimiliano Gobbo
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Corresponding author

Correspondence to Claudio Orizio.

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Gaffurini, P., Neviani, C., Orizio, C. et al. Oxygen supply/uptake mismatch during incremental stimulation of the human tibialis anterior. Sport Sci Health 7, 65–70 (2012). https://doi.org/10.1007/s11332-012-0114-9

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  • DOI: https://doi.org/10.1007/s11332-012-0114-9

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