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ASCT2-Targeting Antibody-Drug Conjugate MEDI7247 in Adult Patients with Relapsed/Refractory Hematological Malignancies: A First-in-Human, Phase 1 Study
BackgroundMEDI7247 is a first-in-class antibody-drug conjugate (ADC) consisting of an anti-sodium-dependent alanine-serine-cysteine transporter 2...
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A unified metric of human immune health
Immunological health has been challenging to characterize but could be defined as the absence of immune pathology. While shared features of some...
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Diverse array of neutralizing antibodies elicited upon Spike Ferritin Nanoparticle vaccination in rhesus macaques
The repeat emergence of SARS-CoV-2 variants of concern (VoC) with decreased susceptibility to vaccine-elicited antibodies highlights the need to...
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Astrophysical Validation
We present examples of validating components of an astrophysical simulationCode code. Problems of stellar astrophysicsAstrophysics are...
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Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations
Prevention of viral escape and increased coverage against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern require...
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The oral microbiome of patients undergoing treatment for severe aplastic anemia: a pilot study
The microbiome, an intriguing component of the human body, composed of trillions of microorganisms, has prompted scientific exploration to identify...
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Pathogenic TERT promoter variants in telomere diseases
PurposeThe acquisition of pathogenic variants in the TERT promoter ( TERTp) region is a mechanism of tumorigenesis. In nonmalignant diseases, TERTp ...
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Nucleosynthesis in Thermonuclear Supernovae
The explosion energy of thermonuclear (type Ia) supernovae is derived from the difference in nuclear binding energy liberated in the explosive fusion...
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Nucleosynthesis in Thermonuclear Supernovae
The explosion energy of thermonuclear (type Ia) supernovae is derived from the difference in nuclear binding energy liberated in the explosive fusion...
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Proteome labeling and protein identification in specific tissues and at specific developmental stages in an animal
Identifying the proteins synthesized at specific times in cells of interest in an animal will facilitate the study of cellular functions and dynamic...
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Pathophysiology and management of thrombocytopenia in bone marrow failure: possible clinical applications of TPO receptor agonists in aplastic anemia and myelodysplastic syndromes
Aplastic anemia is a bone marrow failure syndrome that causes pancytopenia and can lead to life-threatening complications. Bone marrow...
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The influence of chemical composition on models of Type Ia supernovae
Type Ia supernovae are bright stellar explosions distinguished by standardizable light curves that allow for their use as distance indicators for...
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Expanding the genetic code of Drosophila melanogaster
Genetic code expansion for unnatural amino acid mutagenesis has, until recently, been limited to cell culture. We demonstrate the site-specific...
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GeneGrid: Architecture, Implementation and Application
The emergence of Grid computing technology has opened up an unprecedented opportunity for biologists to share and access data, resources and tools in...
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Pygopus and Legless target Armadillo/β-catenin to the nucleus to enable its transcriptional co-activator function
Wnt signalling controls the transcription of genes that function during normal and malignant development
1 ,2 . Stimulation by canonical Wnt ligands...
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White Dwarf Colors in Low Accretion Rate Binaries
Our recent theoretical work (Townsley and Bildsten 2002) on the thermal state of white dwarfs (WDs) in low mass transfer rate binaries allows us to...
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Internal Conditions of Accreting White Dwarfs
We explain the physics of compressional heating of the deep interior of an accreting white dwarf (WD) at accretion rates low enough so that the...
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Projected Dynamics for Metastable Decay in Ising Models
The magnetization switching dynamics in the kinetic Ising model is projected onto a one-dimensional absorbing Markov chain. The resulting projected...
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Family environments of victims of intrafamilial and extrafamilial child sexual abuse
The family environments of Intrafamilial and extrafamilial childhood sexual abuse victims were examined to determine whether characteristics of...