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Article
Open AccessZmGDIα-hel counters the RBSDV-induced reduction of active gibberellins to alleviate maize rough dwarf virus disease
Maize rough dwarf disease (MRDD) threatens maize production globally. The P7-1 effector of the rice black-streaked dwarf virus (RBSDV) targets maize Rab GDP dissociation inhibitor alpha (ZmGDIα) to cause MRDD....
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Article
Open AccessBimetallic nanoalloys planted on super-hydrophilic carbon nanocages featuring tip-intensified hydrogen evolution electrocatalysis
The insufficient availability and activity of interfacial water remain a major challenge for alkaline hydrogen evolution reaction (HER). Here, we propose an “on-site disruption and near-site compensation” stra...
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Article
Open AccessMapping recurrent mosaic copy number variation in human neurons
When somatic cells acquire complex karyotypes, they often are removed by the immune system. Mutant somatic cells that evade immune surveillance can lead to cancer. Neurons with complex karyotypes arise during ...
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Article
Open AccessNeuropathologist-level integrated classification of adult-type diffuse gliomas using deep learning from whole-slide pathological images
Current diagnosis of glioma types requires combining both histological features and molecular characteristics, which is an expensive and time-consuming procedure. Determining the tumor types directly from whol...
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Article
Open AccessComprehensive application of bio-char and nitrogen fertilizer in dry-land maize cultivation
Drought stress and the scarcity of nitrogen fertilizer are two of the important abiotic factors affecting maize growth. Bio-char can enhance the maize yield. Therefore, two field experiments were carried out i...
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Article
Open AccessHelical Indexing in Real Space
Biological structures with helical symmetries of distinct twist, rise, and axial symmetry are abundant and span a wide range of organisms and functions. Performing de novo helical indexing remains challenging ...
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Article
Open AccessPlasticity within the barrel domain of BamA mediates a hybrid-barrel mechanism by BAM
In Gram-negative bacteria, the biogenesis of β-barrel outer membrane proteins is mediated by the β-barrel assembly machinery (BAM). The mechanism employed by BAM is complex and so far- incompletely understood....
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Open AccessFrom machine learning to transfer learning in laser-induced breakdown spectroscopy analysis of rocks for Mars exploration
With the ChemCam instrument, laser-induced breakdown spectroscopy (LIBS) has successively contributed to Mars exploration by determining the elemental compositions of soils, crusts, and rocks. The American Per...
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Article
Open AccessHigh diversity droplet microfluidic libraries generated with a commercial liquid spotter
Droplet libraries consisting of many reagents encapsulated in separate droplets are necessary for applications of microfluidics, including combinatorial chemical synthesis, DNA-encoded libraries, and massively...
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Article
Open AccessCryo-EM structures and functional characterization of homo- and heteropolymers of human ferritin variants
The role of abnormal brain iron metabolism in neurodegenerative diseases is still insufficiently understood. Here, we investigate the molecular basis of the neurodegenerative disease hereditary ferritinopathy ...
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Article
Open AccessMachine Learning Allows Calibration Models to Predict Trace Element Concentration in Soils with Generalized LIBS Spectra
Determination of trace elements in soils with laser-induced breakdown spectroscopy is significantly affected by the matrix effect, due to large variations in chemical composition and physical property of diffe...
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Publisher Correction: Integrating photonics with silicon nanoelectronics for the next generation of systems on a chip
In this Letter, owing to an error during the production process, the author affiliations were listed incorrectly. Affiliation number 5 (Colleges of Nanoscale Science and Engineering, State University of New Yo...
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Open AccessNovel sequences, structural variations and gene presence variations of Asian cultivated rice
Genomic diversity within a species genome is the genetic basis of its phenotypic diversity essential for its adaptation to environments. The big picture of the total genetic diversity within Asian cultivated r...
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Open AccessGenomic variation in 3,010 diverse accessions of Asian cultivated rice
Here we analyse genetic variation, population structure and diversity among 3,010 diverse Asian cultivated rice (Oryza sativa L.) genomes from the 3,000 Rice Genomes Project. Our results are consistent with the f...
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Integrating photonics with silicon nanoelectronics for the next generation of systems on a chip
Electronic and photonic technologies have transformed our lives—from computing and mobile devices, to information technology and the internet. Our future demands in these fields require innovation in each tech...
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Article
Open AccessA mitochondria-targeting artemisinin derivative with sharply increased antitumor but depressed anti-yeast and anti-malaria activities
The potent anti-malarial drug artemisinins are additionally anti-tumorigenic and inhibitory to yeast growth. The action mechanism of artemisinins, however, is not well understood. Heme and mitochondrial membra...
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Article
Open AccessH2S regulates endothelial nitric oxide synthase protein stability by promoting microRNA-455-3p expression
The aims of the present study are to determine whether hydrogen sulfide (H2S) is involved in the expression of endothelial nitric oxide synthase (eNOS) and nitric oxide (NO) production, and to identify the role o...
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Article
Open AccessImmunomagnetic separation of tumor initiating cells by screening two surface markers
Isolating tumor initiating cells (TICs) often requires screening of multiple surface markers, sometimes with opposite preferences. This creates a challenge for using bead-based immunomagnetic separation (IMS) ...
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Article
Open AccessParamagnetic Structures within a Microfluidic Channel for Enhanced Immunomagnetic Isolation and Surface Patterning of Cells
In this report, we demonstrate a unique method for embedding magnetic structures inside a microfluidic channel for cell isolation. We used a molding process to fabricate these structures out of a ferrofluid of...
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Single-chip microprocessor that communicates directly using light
An electronic–photonic microprocessor chip manufactured using a conventional microelectronics foundry process is demonstrated; the chip contains 70 million transistors and 850 photonic components and directly ...