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Article
Effect of lgals3a on embryo development of zebrafish
Our study was aimed to investigate the effects of lgals3a (Gal-3 encoding gene) on the development of zebrafish embryo and its underlying mechanisms. Morpholino (MO) technology was used to inhibit the expressi...
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Article
Single-cell patterning and axis characterization in the murine and human definitive endoderm
Defining the precise regionalization of specified definitive endoderm progenitors is critical for understanding the mechanisms underlying the generation and regeneration of respiratory and digestive organs, ye...
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Article
Open AccessMicroRNA-146a protects against myocardial ischaemia reperfusion injury by targeting Med1
Myocardial ischaemia reperfusion injury (MIRI) is a difficult problem in clinical practice, and it may involve various microRNAs. This study investigated the role that endogenous microRNA-146a plays in myocard...
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Article
Open AccessmiR-146a attenuates apoptosis and modulates autophagy by targeting TAF9b/P53 pathway in doxorubicin-induced cardiotoxicity
Clinical therapy of doxorubicin (DOX) is limited due to its cardiotoxicity. miR-146a was proved as a protective factor in many cardiovascular diseases, but its role in chronic DOX-induced cardiotoxicity is unc...
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Article
The challenges of mainstream deammonification process for municipal used water treatment
The deammonification process combining partial nitritation and anaerobic ammonium oxidation has been considered as a viable option for energy-efficient used water treatment. So far, many full-scale sidestream ...
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Article
1H NMR-based metabolomic analysis of triptolide-induced toxicity in liver-specific cytochrome P450 reductase knockout mice
Triptolide (TL) is an active component of Tripterygium wilfordii Hook. F which is used to treat autoimmune and inflammatory disease. However, a high incidence of adverse effects is often observed in clinic. Pr...
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Article
Modulation of innate immune-related pathways in nicotine-treated SH-SY5Y cells
Although nicotine has a broad impact on both the central and peripheral nervous systems, the molecular mechanisms remain largely unknown, especially at the signaling pathway level. To investigate that aspect, ...
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Article
Crystal structure of a putative transcriptional regulator SCO0520 from Streptomyces coelicolor A3(2) reveals an unusual dimer among TetR family proteins
A structure of the apo-form of the putative transcriptional regulator SCO0520 from Streptomyces coelicolor A3(2) was determined at 1.8 Å resolution. SCO0520 belongs to the TetR family of regulators. In the crysta...
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Article
Retinoic acid inducible gene-I, more than a virus sensor
Retinoic acid inducible gene-I (RIG-I) is a caspase recruitment domain (CARD) containing protein that acts as an intracellular RNA receptor and senses virus infection. After binding to double stranded RNA (dsR...
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Article
Erratum: Klotho suppresses RIG-I-mediated senescence-associated inammation
Nat. Cell Biol. 13, 254–262 (2011); published online 20 February 2011; corrected after print 16 March 2011 In the version of this article initially published online and in print, the middle graph in Figure 3b ...
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Article
Klotho suppresses RIG-I-mediated senescence-associated inflammation
The senescence-associated secretory phenotype (SASP) is a hallmark of senescent cells, but the mechanisms underlying cytokine secretion were unknown. Klotho, a protein with purported anti-ageing effects, is no...
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Article
MEF2C mediates the activation induced cell death (AICD) of macrophages
Activation-induced cell death (AICD) of immune cells is widely believed to be crucial for the regulation of immune responses. Although macrophage apoptosis has been observed under a variety of pathological con...
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Article
High level expression of kringle 5 fragment of plasminogen in Pichia pastoris
Angiogensis can be blocked by inhibitors such as endostatin and angiostatin. The kringle 5 fragment of plasminogen also has a potent inhibitory effect on endothelial cell proliferation and leads to the inhibit...
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Chapter and Conference Paper
Poster Summaries
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Article
Crystal structure of the hypothetical protein TA1238 from Thermoplasma acidophilum: A new type of helical super-bundle
The crystal structure of the hypothetical protein TA1238 from Thermoplasma acidophilum was solved with multiple-wavelength anomalous diffraction and refined at 2.0 Å resolution. The molecule consists of a typical...
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Article
Crystal structure of the hypothetical protein TA1238 from Thermoplasma acidophilum: a new type of helical super-bundle
The crystal structure of the hypothetical protein TA1238 from Thermoplasma acidophilum was solved with multiple-wavelength anomalous diffraction and refined at 2.0 Å resolution. The molecule consists of a typical...
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Article
A novel protein-DNA interaction involved with the CpG dinucleotide at −30 upstream is linked to the DNA methylation mediated transcription silencing of the MAGE-A1 gene
To understand the DNA-methylation mediated gene silencing mechanisms, we analyzed in cell culture of the promoter function of the MAGE-A1 gene, which is frequently demethylated and over-expressed in human hepatoc...
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Article
Prevention of osteoporosis in ovariectomized mice by electroporational gene transfer of parathyroid hormone
Non-viral vector, pCMV-Pth, with full-length human parathyroid hormone (prepro-hPTH) cDNA was constructed and delivered into the ovariectomized mouse quadriceps to explore the effects of electroporational gene...
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Article
The binding of actin to p38 MAPK and inhibiting its kinase activityin vitro
p38 MAP kinase mediates a signal pathway that is involved in many physiological and pathological processes such as inflammation, cellular stress, apoptosis, cell cycle and growth, ischemia/re-perfusion, and my...
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Article
Antisense EGFR sequence enhances apoptosis in a human hepatoma cell line BEL-7404
Effects of antisense epidermal growth factor receptor(EGFR) sequence on apoptotic cell death were examined in a human hepatoma cell line BEL-7404 cells. In the cells of JX-1, a sub clone of BEL-7404 stably tra...