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Article
Open AccessLithium carbonate-promoted mixed rare earth oxides as a generalized strategy for oxidative coupling of methane with exceptional yields
The oxidative coupling of methane to higher hydrocarbons offers a promising autothermal approach for direct methane conversion, but its progress has been hindered by yield limitations, high temperature require...
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Article
Open AccessRemodeling articular immune homeostasis with an efferocytosis-informed nanoimitator mitigates rheumatoid arthritis in mice
Massive intra-articular infiltration of proinflammatory macrophages is a prominent feature of rheumatoid arthritis (RA) lesions, which are thought to underlie articular immune dysfunction, severe synovitis and...
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Article
Open AccessMetal single-site catalyst design for electrocatalytic production of hydrogen peroxide at industrial-relevant currents
Direct hydrogen peroxide (H2O2) electrosynthesis via the two-electron oxygen reduction reaction is a sustainable alternative to the traditional energy-intensive anthraquinone technology. However, high-performance...
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Article
Open AccessMotion control and positioning system of multi-sensor tunnel defect inspection robot: from methodology to application
As the mileage of subway is increasing rapidly, there is an urgent need for automatic subway tunnel inspection equipment to ensure the efficiency and frequency of daily tunnel inspection. The subway tunnel env...
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Article
Open AccessInvestigation of the effect of fly ash content on the bonding performance of CFRP-concrete interface in sulfate environment
The present study focuses on the investigation of the interfacial bond behavior of carbon fiber-reinforced polymer (CFRP)-concrete under dry–wet sulfate cycles by double-sided shear testing. Besides, the effec...
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Article
Open AccessPiperazine-derived lipid nanoparticles deliver mRNA to immune cells in vivo
In humans, lipid nanoparticles (LNPs) have safely delivered therapeutic RNA to hepatocytes after systemic administration and to antigen-presenting cells after intramuscular injection. However, systemic RNA del...
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Article
Open AccessDifferential neutralization and inhibition of SARS-CoV-2 variants by antibodies elicited by COVID-19 mRNA vaccines
The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in the emergence of new variant lineages that have exacerbated the COVID-19 pandemic. Some of those variants were desi...
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Article
Open AccessHeparin induces α-synuclein to form new fibril polymorphs with attenuated neuropathology
α-Synuclein (α-syn), as a primary pathogenic protein in Parkinson’s disease (PD) and other synucleinopathies, exhibits a high potential to form polymorphic fibrils. Chemical ligands have been found to involve ...
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Article
Open AccessCryo-EM structure of an amyloid fibril formed by full-length human SOD1 reveals its conformational conversion
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease. Misfolded Cu, Zn-superoxide dismutase (SOD1) has been linked to both familial and sporadic ALS. SOD1 fibrils formed in vitro share toxic prop...
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Article
Open AccessPerirenal adipose afferent nerves sustain pathological high blood pressure in rats
Hypertension is a pathological condition of persistent high blood pressure (BP) of which the underlying neural mechanisms remain obscure. Here, we show that the afferent nerves in perirenal adipose tissue (PRA...
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Article
Open AccessA simple and rapid method for fish sex identification based on recombinase-aided amplification and its use in Cynoglossus semilaevis
Fish sex identification is a basic technique of great importance for both fish genetic studies and fisheries. Due to the sexual reversal phenomenon in many fish species, a simple and rapid molecular identifica...
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Article
Open AccessMonocarborane cluster as a stable fluorine-free calcium battery electrolyte
High-energy-density and low-cost calcium (Ca) batteries have been proposed as ‘beyond-Li-ion’ electrochemical energy storage devices. However, they have seen limited progress due to challenges associated with ...
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Article
Open AccessThe nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structure
Human heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) serves as a key regulating protein in RNA metabolism. Malfunction of hnRNPA1 in nucleo-cytoplasmic transport or dynamic phase separation leads to abno...
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Article
Open AccessMechanisms of the regulation of ester balance between oxidation and esterification in aged Baijiu
The influence of oxidation and esterification on the ester balance of aged Baijiu and methodology for the rational design of liquor flavors to optimize the practice of Baijiu production are not completely unde...
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Article
Open AccessParkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure
Amyloid aggregation of α-synuclein (α-syn) is closely associated with Parkinson’s disease (PD) and other synucleinopathies. Several single amino-acid mutations (e.g. E46K) of α-syn have been identified causati...
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Article
Open AccessSelective electroreduction of CO2 to acetone by single copper atoms anchored on N-doped porous carbon
Efficient electroreduction of CO2 to multi-carbon products is a challenging reaction because of the high energy barriers for CO2 activation and C–C coupling, which can be tuned by designing the metal centers and ...
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Article
Open AccessEmergent tetratic order in crowded systems of rotationally asymmetric hard kite particles
Considering multi-body systems of monodisperse hard Brownian particles, it remains challenging to predict the forms of order that can emerge in their dense assembled structures. Surprisingly, here, using Monte...
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Article
Open AccessStructural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly
Subcellular membrane-less organelles consist of proteins with low complexity domains. Many of them, such as hnRNPA1, can assemble into both a polydisperse liquid phase and an ordered solid phase of amyloid fib...
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Article
Open AccessSurface chromium on Terracotta Army bronze weapons is neither an ancient anti-rust treatment nor the reason for their good preservation
For forty years, there has been a widely held belief that over 2,000 years ago the Chinese Qin developed an advanced chromate conversion coating technology (CCC) to prevent metal corrosion. This belief was bas...
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Open AccessA peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma
Circular RNAs (circRNAs) are a large class of transcripts in the mammalian genome. Although the translation of circRNAs was reported, additional coding circRNAs and the functions of their translated products r...