144 Result(s)
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Article
Open AccessDoE-Aided Optimization of RP-HPLC Method for Simultaneous Estimation of Amoxicillin and Tinidazole Loaded Mucoadhesive GRDDS Formulation for the Treatment of H. pylori
Helicobacter pylori (H. pylori) infection is one of the primary risk factors of peptic ulcer disease worldwide. Treatment of H. pylori with the conventional dosage form is often challenging due to the ineffective...
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Open AccessValidation and Application of a Dried Blood Spot Amoxicillin Assay
Dried blood spot (DBS) antibiotic assays can facilitate pharmacokinetic (PK) investigations in situations where venous blood sampling is logistically and/or ethically challenging. The aim of this study was to ...
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Open AccessApplication High-Performance Thin-Layer Chromatography with Controlled Eluent Velocity to Determine Fingerprints of Various Poplar Species Buds Extracts: Optimization of Operating Variables
The study used the prototype device enabling the development of isocratic and gradient thin-layer chromatograms with controlled eluent velocity to obtain fingerprints of extracts from buds of various poplar sp...
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Open AccessMeasurement of Serum Vitamins B2 and B6 in Patients with Hashimoto’s Thyroiditis by LC–MS/MS Method
Vitamin B2 and vitamin B6 are cofactors and coenzymes in many biochemical reactions, and their sufficient serum concentrations may be crucial for the proper functioning of the thyroid gland. The aim of the stu...
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Open AccessSimultaneous Analysis of Formaldehyde and Methanol Emissions During Curing Reactions of Polyester-melamine Coatings
This paper introduces a new derivatization agent for the simultaneous quantification of formaldehyde and methanol during curing reactions of complex organic coatings. Formaldehyde emitted from a polyester-mela...
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Open AccessA Complete Analysis Pipeline for the Processing, Alignment and Quantification of HPLC–UV Wine Chromatograms
Elucidating the chemistry of wine would help defining its quality, chemical and sensory characteristics and optimise the wine-making processes. High-performance liquid chromatography coupled with UV–Vis spectr...
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Open AccessDetermination of New 4-Aryl-pyrido[1,2-c]pyrimidine Derivatives, Potential Antidepressant Agents with a High Affinity to 5-Hydroxytryptamin 1A Receptor and Serotonin Transporter Protein Receptor, with Capillary Electrophoresis
A novel capillary electrophoresis method was developed for the determination of new 4-aryl-pyrido[1,2-c]pyrimidine derivatives, potential antidepressant agents, in serum. The derivatives have conformationally ...
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Open AccessCharacterizing Styrene Monomer and Oligomers by SEC/MALS/VISC/DRI
Worldwide polystyrene (PS) production in 2020 was approximately 27 million metric tons, distributed among many nations, making it one of the most heavily imported and exported chemicals. Commercially produced ...
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Open AccessChemical Composition Analysis and Multi-index Component Content Determination of Compounds in Goupi Plaster Based on UPLC–Q-Exactive-MS and UPLC–MS/MS
This study sought to evaluate and validate a method for chemical composition analysis and content determination of Goupi plaster components, a conventional prescription preparation of traditional Chinese medic...
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Open AccessGlycerol-Based Green RP-HPLC Method for Simultaneous Determination of Methionine and Paracetamol in Pharmaceutical Tablets
Methionine and paracetamol are combined in dosage forms due to the ability of methionine to compensate the deficiency in glutathione in hepatic patients. In this work, an innovative simple time-saving green RP...
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Article
Open AccessBiosilica as a New Stationary Phase in HILIC Mode
The aim of this work was to use the biosilica obtained from diatoms (microalgae) cultivated under laboratory conditions as a new stationary phase to fill the chromatographic column and test it in high-performa...
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Open AccessStudy of Effect of Incubation Time and Temperature on the Linear Polyacrylamide-Coating Performance for the Separation of Proteins by Capillary Zone Electrophoresis
The preparation of linear polyacrylamide (LPA)-coated capillary is a multistep, laborious process. In this study, five different LPA-coating procedures were compared regarding the capillary pretreatment (incub...
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Article
Open AccessApplication of UPLC-MS/MS Method for Analysis of Apigenin, Apigenin 7-Glucoside and Chlorogenic Acid in Goat Serum
UPLC-MS/MS method was developed for determination of bioactive compounds including chlorogenic acid (CA), apigenin (AP) and apigenin 7-glucoside (AP7G) in goat serum. The analytes were separated on Kinetex C18...
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Open AccessStudy on Quality Control of Tenofovir Disoproxil Fumarate Enantiomers by High-Performance Liquid Chromatography–Mass Spectrometry
This study aims at developing a high-performance liquid chromatography–mass spectrometry (LC–MS) method to analyze tenofovir disoproxil fumarate (TDF) and its pharmaceutical preparations. Several cyclodextrin ...
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Open AccessFDA-Validated Ecofriendly Chromatographic Methods for Simultaneous Determination of Gemcitabine and Sorafenib: Applications to Pharmacokinetics
Combination therapy of gemcitabine and sorafenib is synergistically effective and well tolerated in patients with non-small cell lung cancer (NSCLC). In this study, the pharmacokinetic parameters of both gemci...
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Open AccessMethod Development, Optimization, and Validation of the Separation of Ketamine Enantiomers by Capillary Electrophoresis Using Design of Experiments
Capillary electrophoresis was chosen as cost-effective and robust method to separate ketamine enantiomers. For the method development, first different native and modified cyclodextrins were tested. The most pr...
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Article
Open AccessFlow Dynamics and Analyte Transfer in a Microfluidic Device for Spatial Two-Dimensional Separations
In the last decade, chip-based separations have become a major area of interest in the field of separation science, especially for the development of “spatial” two-dimensional liquid chromatography (xLC × xLC). I...
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Open AccessFour Greenness Evaluations of Two Chromatographic Methods: Application to Fluphenazine HCl and Nortriptyline HCl Pharmaceutical Combination in Presence of Their Potential Impurities Perphenazine and Dibenzosuberone
Nowadays, when analysts develop a new method, they are taking into consideration the green aspects of the developed method. Two chromatographic methods were developed for the determination of antidepressant p...
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Open AccessA Non-aqueous Capillary Electrophoresis for Determination of Eugenol in Cloves and Dental Preparations
A total non-aqueous capillary electrophoresis method was developed and applied for the first time for the quantification of eugenol in cloves and dental preparations. The optimized conditions included a buffer...
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Open AccessIntroduction of Octadecyl-Bonded Porous Particles in 3D-Printed Transparent Housings with Multiple Outlets
Microfluidic devices for comprehensive three-dimensional spatial liquid chromatography will ultimately require a body of stationary phase with multiple in- and outlets. In the present work, 3D printing with a ...
