The Wiskott-Aldrich syndrome protein (WASp) is mutated in the severe immunodeficiency disease Wis... more The Wiskott-Aldrich syndrome protein (WASp) is mutated in the severe immunodeficiency disease Wiskott-Aldrich syndrome (WAS). The function of B cells and the physiologic alterations in WAS remain unclear. We show that B cells from WAS patients exhibited decreased motility and had reduced capacity to migrate, adhere homotypically, and form long protrusions after in vitro culture. WASp-deficient murine B cells also migrated less well to chemokines. Upon antigen challenge, WASp-deficient mice mounted a reduced and delayed humoral immune response to both T-cell–dependent and –independent antigens. This was at least in part due to deficient migration and homing of B cells. In addition, the germinal center reaction was reduced in WASp-deficient mice. Thus, WASp is crucial for optimal B-cell responses and plays a pivotal role in the primary humoral immune response.
Biodiversity often suffers from urbanisation. In the present study, we focused on how the age of ... more Biodiversity often suffers from urbanisation. In the present study, we focused on how the age of urbanisation affects the richness of 17 epiphytic lichens species and their cover on large oaks, wit ...
Methane (CH4) emissions via emergent aquatic macrophytes can contribute substantially to the glob... more Methane (CH4) emissions via emergent aquatic macrophytes can contribute substantially to the global CH4 balance. We addressed temporal variability in CH4 flux by using the static chamber approach to quantify fluxes from plots dominated by two species considered to differ in flux transport mechanisms (Phragmites australis, Carex rostrata). Temporal variability in daily mean emissions from early June to early October was substantial. The variable that best explained this variation was air temperature. Regular and consistent diel changes were absent and therefore less relevant to include when estimating or modelling CH4 emissions. Methane emissions per m(2) from nearby plots were similar for Phragmites australis and Carex rostrata indicating that CH4 production in the system influenced emissions more than the species identity. This study indicates that previously observed diel patterns and species-effects on emissions require further evaluation to support improved local and regional CH...
Abstract Butterfly conservation in Europe is mainly focused on well-defined grassland habitat pat... more Abstract Butterfly conservation in Europe is mainly focused on well-defined grassland habitat patches. Such an approach ignores the impact of the surrounding landscape, which may contain complementary resources and facilitate dispersal. Here, we investigated butterfly species richness and abundance in a habitat normally regarded as unsuitable matrix: production forestry clear-cuts. Butterflies were recorded in 48 clear-cuts in southern Sweden differing with regards to the time since clear-cutting and land-use history (meadow or forest based on historical maps from the 1870s). All clear-cuts had been managed as production forests for at least 80–120 years. A total of 39 species were found in clear-cuts of both land-use histories, but clear-cuts with a history as meadow had on average 34% higher species richness and 19% higher abundance than did clear-cuts with a history as forest. No effect of the time since clear-cutting was found, irrespective of land-use history, which was likely due to the narrow timespan sampled (
The Wiskott-Aldrich syndrome protein (WASp) is mutated in the severe immunodeficiency disease Wis... more The Wiskott-Aldrich syndrome protein (WASp) is mutated in the severe immunodeficiency disease Wiskott-Aldrich syndrome (WAS). The function of B cells and the physiologic alterations in WAS remain unclear. We show that B cells from WAS patients exhibited decreased motility and had reduced capacity to migrate, adhere homotypically, and form long protrusions after in vitro culture. WASp-deficient murine B cells also migrated less well to chemokines. Upon antigen challenge, WASp-deficient mice mounted a reduced and delayed humoral immune response to both T-cell–dependent and –independent antigens. This was at least in part due to deficient migration and homing of B cells. In addition, the germinal center reaction was reduced in WASp-deficient mice. Thus, WASp is crucial for optimal B-cell responses and plays a pivotal role in the primary humoral immune response.
Biodiversity often suffers from urbanisation. In the present study, we focused on how the age of ... more Biodiversity often suffers from urbanisation. In the present study, we focused on how the age of urbanisation affects the richness of 17 epiphytic lichens species and their cover on large oaks, wit ...
Methane (CH4) emissions via emergent aquatic macrophytes can contribute substantially to the glob... more Methane (CH4) emissions via emergent aquatic macrophytes can contribute substantially to the global CH4 balance. We addressed temporal variability in CH4 flux by using the static chamber approach to quantify fluxes from plots dominated by two species considered to differ in flux transport mechanisms (Phragmites australis, Carex rostrata). Temporal variability in daily mean emissions from early June to early October was substantial. The variable that best explained this variation was air temperature. Regular and consistent diel changes were absent and therefore less relevant to include when estimating or modelling CH4 emissions. Methane emissions per m(2) from nearby plots were similar for Phragmites australis and Carex rostrata indicating that CH4 production in the system influenced emissions more than the species identity. This study indicates that previously observed diel patterns and species-effects on emissions require further evaluation to support improved local and regional CH...
Abstract Butterfly conservation in Europe is mainly focused on well-defined grassland habitat pat... more Abstract Butterfly conservation in Europe is mainly focused on well-defined grassland habitat patches. Such an approach ignores the impact of the surrounding landscape, which may contain complementary resources and facilitate dispersal. Here, we investigated butterfly species richness and abundance in a habitat normally regarded as unsuitable matrix: production forestry clear-cuts. Butterflies were recorded in 48 clear-cuts in southern Sweden differing with regards to the time since clear-cutting and land-use history (meadow or forest based on historical maps from the 1870s). All clear-cuts had been managed as production forests for at least 80–120 years. A total of 39 species were found in clear-cuts of both land-use histories, but clear-cuts with a history as meadow had on average 34% higher species richness and 19% higher abundance than did clear-cuts with a history as forest. No effect of the time since clear-cutting was found, irrespective of land-use history, which was likely due to the narrow timespan sampled (
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