Shravan Kumar Paswan, M.Pharm (Pharmacology) is a Doctoral Research Scholar at CSIR-National Botanical Research Institute in the division of Pharmacognosy and Ethnopharmacology Division. Shravan Kumar Paswan has good scientific papers and projects either presented or published. His worked area is mainly Wound healing, Preclinical Toxicological Evaluation, Reproductive Toxicity, Antiarthiritic activity, Anti Inflammatory activity, Hepatoprotective, Anti-diabetic, Anti-ulcer activity study from natural sources/medicinal plants. He is expert in pharmacological screening of drugs/medicinal plant on rodents. He is regular sought after and requested lecturer at the various pharmacy colleges. Phone: +91-9935603068,9450170975 Address: CSIR-National Botanical Research institute, Lucknow
Journal of biologically active products from nature, Jul 4, 2021
Abstract The present study was performed to determine analgesia and anti-inflammatory activities ... more Abstract The present study was performed to determine analgesia and anti-inflammatory activities of whole plant extract of Selaginella bryopteris on animals. The extract of S. bryopteris whole plant was performed using ethanol (70%) as a solvent. The phytochemical investigation of plant extract was done to evaluated secondary metabolites present in the plant. It was further characterized using HPTLC technique to identify active constituents present in the S. bryopteris extract. The efficacy of plant extract was evaluated using the hot plate method and tail flick method against pain and carrageenan-induced paw oedema model against inflammation. Results exhibited that S. bryopteris extract possesses alkaloids, glycosides, tannins, saponins, flavonoids, carbohydrate, protein and amino acids, steroids, vitamins, gums and mucilages. HPTLC fingerprinting analysis revealed the presence of gallic acid and rutin as active constituents present in the plant extract. S. bryopteris extract showed significant analgesic and anti-inflammatory activities. Thus, it can be used as a safer alternative drug against pain and inflammation in comparison to existing non-steroidal anti-inflammatory drugs (NSAIDs).
Background: Diabetic peripheral neuropathy is the most common complication of diabetes mellitus. ... more Background: Diabetic peripheral neuropathy is the most common complication of diabetes mellitus. Epalrestat, an aldose reductase inhibitor, has been approved for clinical therapy for diabetic peripheral neuropathic pain. In the present study, solid lipid-based nanoparticles are used for oral administration of epalrestat (E-SLN) and evaluated against diabetic neuropathic pain in a rat model. Method: Experimental diabetes in rats was induced by a single dose of streptozotocin (STZ) administration. The therapeutic efficiency of Epalrestat nanoparticles (0.25, 0.50, 1, and 5 mg/kg) in diabetic rats was studied. STZ induced diabetic rats were treated with different doses of E-SLN for 8 weeks. The nanoparticles were orally administered at a single dose in rats, and the various parameters related to peripheral neuropathy were evaluated and compared with the bare drug. The blood glucose level was estimated by standard glucometer, HbA1c, triglycerides, total cholesterol and liver function te...
Background: The ethanomedicinal importance of Moringa concanensis Nimmo plant is reflected in the... more Background: The ethanomedicinal importance of Moringa concanensis Nimmo plant is reflected in the Ayurvedic and traditional system of medicine. It has vast usage in Ayurvedic preparation and diabetes management. Aims of the Study: The research was centered on bringing out the hyperglycemic capabilities of Moringa concanensis Nimmo leaves, and their ethanolic extract (PE) on alloxan monohydrate (AXM) induced diabetic rat model. Materials and Methods: Wistar rats were made diabetic by AXM and treated with PE (200 mg/kg body weight) and glibenclamide as the standard drug. All essential parameters like fasting blood glucose (FBS), post-prandial blood glucose (PPBS), AST, ALT, ALP, ACP, LDH, and oxidative stress markers were measured. Also, to observe β-cells structures, histology of the pancreas was studied. Results: The non-toxicity of PE dose was confirmed by an acute toxicity study. This study model helped determine the anti-hyperglycemic effects of PE by decreasing FBS and PPBS leve...
Wound mending is a complex organic cycle that brings about the reclamation of tissue honesty. Phy... more Wound mending is a complex organic cycle that brings about the reclamation of tissue honesty. Physiologically, it very well may be separated into four particular periods of hemostasis, inflammation, proliferation, and tissue remodeling (redesigning). This chapter portrays the cellular premise of wound mending and extracellular flagging cycles, which is responsible to control them. The capacity of fibroblasts, neutrophils, platelets, and macrophages is contemplated exhaustively. The idea of mending by essential and optional expectation is talked about. Numerous components are known to unfavorably influence mending including undernourishment, hypoxia, immunosuppression, ongoing sickness, and medical procedure. It is fundamental that specialists comprehend the key physiological cycles associated with mending to limit patient illness from postponed recuperating.
Introduction and objective: The scientific assessment of medicinal plants used in the preparation... more Introduction and objective: The scientific assessment of medicinal plants used in the preparation of folk remedies has contributed modern medicine with effective pharmaceuticals for the treatment of diseases. Objective: The 50 % ethonolic extract of solanum xanthocarpum (Solanaceae) whole plant was explored for its hepatoprotective and antioxidant effects on RIF+INH (50 mg/kg) induced acute liver damage in Wistar albino rats.
Ethonolic whole plant extract of Musa paradisica has a multiple pharmacological activities includ... more Ethonolic whole plant extract of Musa paradisica has a multiple pharmacological activities including antimicrobial, antiviral, antiinflammatory, anticancer effects. The present study aims to determine the effect of Musa paradisica on serum and tissue superoxide dismutase (SOD) levels and the histology in carbon tetrachloride (CCl4)-induced liver injury. Wister rats aged were injected Intraperitoneally with 50% CCl4 in olive oil. Musa paradisica was orally administered before or after CCl4 treatment in various groups. Twenty-four hours after CCl4 injection, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, serum and liver superoxide dismutase (SOD) activities were measured and Histological changes of liver were examined by microscopy. Serum ALT and AST activities significantly decreased in a dose-dependent manner in both pre-treatment and post-treatment groups with ethonolic whole plant extract of Musa paradisica. The present study demonstrates tha...
Journal for Research in Applied Sciences and Biotechnology
This article provides a concise summary of the recent developments that have been achieved in our... more This article provides a concise summary of the recent developments that have been achieved in our comprehension of the asymmetric addition processes that are catalysed by native Cinchona alkaloids and their derivatives. This class of reactions includes cycloadditions, 1,4-adds, direct nucleophilic additions across carbon–oxygen or carbon–nitrogen double bonds, and direct nucleophilic additions across carbon–oxygen double bonds. Because of their capacity to catalyse the addition of a wide variety of functional groups to C9, many Cinchona alkaloids have been utilised in these processes as catalysts. These functional groups include amino, alkoxy, hydroxyl, amido, urea, and thiourea, among others. The importance of mechanical variables is emphasised in many different contexts. Additionally, the utilisation of adducts in future synthesis is sometimes broken down into its component steps. Ocimum basilicum was discovered to be mostly consisted of estragol (> 35.71 percent), (E)-ocimene ...
Glaucoma refers to a group of eye conditions that lead to damage to the optic nerve, the nerve th... more Glaucoma refers to a group of eye conditions that lead to damage to the optic nerve, the nerve that carries visual information from the eye to the brain. In many cases, damage to the optic nerve is due to increased pressure in the eye, also known as intraocular pressure. Glaucoma is a disease of the optic nerve that affects approximately 60 million people globally. It is the second most common cause of blindness, leaving an estimated 7.5 million people blind. In India it affects 11 million people, of which 1.5 million are blind. Glaucoma is a disease that is often associated with elevated intraocular pressure, in which damage to the eye (optic) nerve can lead to loss of vision and even blindness. Glaucoma is the leading cause of irreversible blindness in the world. Glaucoma usually causes no symptoms early in its course, at which time it can only be diagnosed by regular eye examinations and screenings with the frequency of examination based on age and the presence of other risk fact...
1. Institute of pharmaceutical research, GLA University, Mathura, India 2. Advance institute of b... more 1. Institute of pharmaceutical research, GLA University, Mathura, India 2. Advance institute of biotech & paramedical sciences, kanpur 3. Karpagam University, Coimbatore, Tamil Nadu, India Chronopharmacology is the study of the manner & extent to which the kinetics & dynamics of medication directly affected by endogenous biological rhythm & also how the dosing time of medications affects biological timekeeping & features ( period, level, amplitude & phase ) of biological rhythms. Chronopharmacology includes chronopharmacotherapy, chronopharmacokinetics & Chronotoxity. Chronopharmacotherapy is the investigative science that elucidates the biological rhythm dependencies of medication. It is useful to solve problems of drug optimization i.e. to enhance the desired efficiency or to reduce its undesired effects. So Chronopharmacologic approaches involve a lesser risk of errors and or false information than the conventional homeostatic approach. The effectiveness & toxicity of many drugs ...
Journal of biologically active products from nature, Jul 4, 2021
Abstract The present study was performed to determine analgesia and anti-inflammatory activities ... more Abstract The present study was performed to determine analgesia and anti-inflammatory activities of whole plant extract of Selaginella bryopteris on animals. The extract of S. bryopteris whole plant was performed using ethanol (70%) as a solvent. The phytochemical investigation of plant extract was done to evaluated secondary metabolites present in the plant. It was further characterized using HPTLC technique to identify active constituents present in the S. bryopteris extract. The efficacy of plant extract was evaluated using the hot plate method and tail flick method against pain and carrageenan-induced paw oedema model against inflammation. Results exhibited that S. bryopteris extract possesses alkaloids, glycosides, tannins, saponins, flavonoids, carbohydrate, protein and amino acids, steroids, vitamins, gums and mucilages. HPTLC fingerprinting analysis revealed the presence of gallic acid and rutin as active constituents present in the plant extract. S. bryopteris extract showed significant analgesic and anti-inflammatory activities. Thus, it can be used as a safer alternative drug against pain and inflammation in comparison to existing non-steroidal anti-inflammatory drugs (NSAIDs).
Background: Diabetic peripheral neuropathy is the most common complication of diabetes mellitus. ... more Background: Diabetic peripheral neuropathy is the most common complication of diabetes mellitus. Epalrestat, an aldose reductase inhibitor, has been approved for clinical therapy for diabetic peripheral neuropathic pain. In the present study, solid lipid-based nanoparticles are used for oral administration of epalrestat (E-SLN) and evaluated against diabetic neuropathic pain in a rat model. Method: Experimental diabetes in rats was induced by a single dose of streptozotocin (STZ) administration. The therapeutic efficiency of Epalrestat nanoparticles (0.25, 0.50, 1, and 5 mg/kg) in diabetic rats was studied. STZ induced diabetic rats were treated with different doses of E-SLN for 8 weeks. The nanoparticles were orally administered at a single dose in rats, and the various parameters related to peripheral neuropathy were evaluated and compared with the bare drug. The blood glucose level was estimated by standard glucometer, HbA1c, triglycerides, total cholesterol and liver function te...
Background: The ethanomedicinal importance of Moringa concanensis Nimmo plant is reflected in the... more Background: The ethanomedicinal importance of Moringa concanensis Nimmo plant is reflected in the Ayurvedic and traditional system of medicine. It has vast usage in Ayurvedic preparation and diabetes management. Aims of the Study: The research was centered on bringing out the hyperglycemic capabilities of Moringa concanensis Nimmo leaves, and their ethanolic extract (PE) on alloxan monohydrate (AXM) induced diabetic rat model. Materials and Methods: Wistar rats were made diabetic by AXM and treated with PE (200 mg/kg body weight) and glibenclamide as the standard drug. All essential parameters like fasting blood glucose (FBS), post-prandial blood glucose (PPBS), AST, ALT, ALP, ACP, LDH, and oxidative stress markers were measured. Also, to observe β-cells structures, histology of the pancreas was studied. Results: The non-toxicity of PE dose was confirmed by an acute toxicity study. This study model helped determine the anti-hyperglycemic effects of PE by decreasing FBS and PPBS leve...
Wound mending is a complex organic cycle that brings about the reclamation of tissue honesty. Phy... more Wound mending is a complex organic cycle that brings about the reclamation of tissue honesty. Physiologically, it very well may be separated into four particular periods of hemostasis, inflammation, proliferation, and tissue remodeling (redesigning). This chapter portrays the cellular premise of wound mending and extracellular flagging cycles, which is responsible to control them. The capacity of fibroblasts, neutrophils, platelets, and macrophages is contemplated exhaustively. The idea of mending by essential and optional expectation is talked about. Numerous components are known to unfavorably influence mending including undernourishment, hypoxia, immunosuppression, ongoing sickness, and medical procedure. It is fundamental that specialists comprehend the key physiological cycles associated with mending to limit patient illness from postponed recuperating.
Introduction and objective: The scientific assessment of medicinal plants used in the preparation... more Introduction and objective: The scientific assessment of medicinal plants used in the preparation of folk remedies has contributed modern medicine with effective pharmaceuticals for the treatment of diseases. Objective: The 50 % ethonolic extract of solanum xanthocarpum (Solanaceae) whole plant was explored for its hepatoprotective and antioxidant effects on RIF+INH (50 mg/kg) induced acute liver damage in Wistar albino rats.
Ethonolic whole plant extract of Musa paradisica has a multiple pharmacological activities includ... more Ethonolic whole plant extract of Musa paradisica has a multiple pharmacological activities including antimicrobial, antiviral, antiinflammatory, anticancer effects. The present study aims to determine the effect of Musa paradisica on serum and tissue superoxide dismutase (SOD) levels and the histology in carbon tetrachloride (CCl4)-induced liver injury. Wister rats aged were injected Intraperitoneally with 50% CCl4 in olive oil. Musa paradisica was orally administered before or after CCl4 treatment in various groups. Twenty-four hours after CCl4 injection, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, serum and liver superoxide dismutase (SOD) activities were measured and Histological changes of liver were examined by microscopy. Serum ALT and AST activities significantly decreased in a dose-dependent manner in both pre-treatment and post-treatment groups with ethonolic whole plant extract of Musa paradisica. The present study demonstrates tha...
Journal for Research in Applied Sciences and Biotechnology
This article provides a concise summary of the recent developments that have been achieved in our... more This article provides a concise summary of the recent developments that have been achieved in our comprehension of the asymmetric addition processes that are catalysed by native Cinchona alkaloids and their derivatives. This class of reactions includes cycloadditions, 1,4-adds, direct nucleophilic additions across carbon–oxygen or carbon–nitrogen double bonds, and direct nucleophilic additions across carbon–oxygen double bonds. Because of their capacity to catalyse the addition of a wide variety of functional groups to C9, many Cinchona alkaloids have been utilised in these processes as catalysts. These functional groups include amino, alkoxy, hydroxyl, amido, urea, and thiourea, among others. The importance of mechanical variables is emphasised in many different contexts. Additionally, the utilisation of adducts in future synthesis is sometimes broken down into its component steps. Ocimum basilicum was discovered to be mostly consisted of estragol (> 35.71 percent), (E)-ocimene ...
Glaucoma refers to a group of eye conditions that lead to damage to the optic nerve, the nerve th... more Glaucoma refers to a group of eye conditions that lead to damage to the optic nerve, the nerve that carries visual information from the eye to the brain. In many cases, damage to the optic nerve is due to increased pressure in the eye, also known as intraocular pressure. Glaucoma is a disease of the optic nerve that affects approximately 60 million people globally. It is the second most common cause of blindness, leaving an estimated 7.5 million people blind. In India it affects 11 million people, of which 1.5 million are blind. Glaucoma is a disease that is often associated with elevated intraocular pressure, in which damage to the eye (optic) nerve can lead to loss of vision and even blindness. Glaucoma is the leading cause of irreversible blindness in the world. Glaucoma usually causes no symptoms early in its course, at which time it can only be diagnosed by regular eye examinations and screenings with the frequency of examination based on age and the presence of other risk fact...
1. Institute of pharmaceutical research, GLA University, Mathura, India 2. Advance institute of b... more 1. Institute of pharmaceutical research, GLA University, Mathura, India 2. Advance institute of biotech & paramedical sciences, kanpur 3. Karpagam University, Coimbatore, Tamil Nadu, India Chronopharmacology is the study of the manner & extent to which the kinetics & dynamics of medication directly affected by endogenous biological rhythm & also how the dosing time of medications affects biological timekeeping & features ( period, level, amplitude & phase ) of biological rhythms. Chronopharmacology includes chronopharmacotherapy, chronopharmacokinetics & Chronotoxity. Chronopharmacotherapy is the investigative science that elucidates the biological rhythm dependencies of medication. It is useful to solve problems of drug optimization i.e. to enhance the desired efficiency or to reduce its undesired effects. So Chronopharmacologic approaches involve a lesser risk of errors and or false information than the conventional homeostatic approach. The effectiveness & toxicity of many drugs ...
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