Vikas Jhawat

M.M.UNIVERSITY, MULLANA, AMBALA, INDIA, M.M.COLLEGE OF PHARMACY, RESEARCH SCHOLAR

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Master’s in Pharmacy with specialization in Pharmaceutics. GPAT qualified with very good academic record. Dedicated, high performing, enthusiastic and strategic-thinking professional having a work experience of 1 year 7 months in Quality control in the field of Pharma manufacturing. Highly skilled in chemical and instrumental analysis of raw material and finished products, QC documentation, data integrity checks and faced various regulatory/semi regulatory audits including EU-GMP.
Underwent a practical training in Pharmacovigilance case processing including-
• Assessment of case reports for seriousness, causality and expectedness, case triage etc.
• Participated in the case review process applying a high standard of quality review to ensure sound medical safety data documentation
• Well versed with ICH guidelines including basic understanding of regulatory requirements for clinical research and Pharmacovigilance
• Understanding of Drug Development Process including Drug safety and different Phases of Clinical Trials.

Possess strong written and verbal communication skills. A flexible attitude with respect to learning.

With this knowledge and the training gained during my studies and training I am sure that I am competent enough to fulfill the needs and demands of any esteemed organization and I intend to work in an environment that enhances my skills and motivates me to utilize my potential to the fullest extent to contribute to the company both individually as well as a team.
Supervisors: Dr. Sumeet Gupta and Dr. Vipin Saini

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Papers by Vikas Jhawat

Current Remedial Strategies for the Treatment of Rheumatoid Arthritis through the Oral Route with Janus Kinase Inhibitors

Drug Delivery Letters

: Rheumatoid arthritis (RA) is a well-known chronic inflammatory disease that results in articula... more : Rheumatoid arthritis (RA) is a well-known chronic inflammatory disease that results in articular degradation, comorbidities, and body part functional loss. In the last two decades, the development of effective biologics and small compounds, such as Janus kinase inhibitors (Jakinibs), has significantly improved clinical outcomes. Low-molecular-weight chemicals known as jakinibs are currently used for effective treatment of RA. Jakinibs are a new class of drugs being developed to treat RA, and several of them are now in different phases of clinical trials to establish their safety and efficacy in humans. Jakinibs can be very different in their selectivity against JAK inhibitors. For an efficient therapy of RA, it is critical to fully comprehend the properties of JAK inhibitors as well as their mechanism of action. Tofacitinib, Baricitinib, Upadacitinib, Peficitinib, Filgotinib, Decernotinib, Itacitinib, Ruxolitinib, and PF-06651600 are a few selective orally active Jakinibs that have entered clinical trials to treat RA. This review aims to elaborate on Jakinibs for the treatment of Rheumatoid Arthritis (RH), including their mechanism of action (MOA), efficacy and safety profiles, clinical trials of adverse effects (AEs) associated with Jakinibs and combination therapy with other DMARDs.

In vitro characterization of tofacitinib loaded novel nanoemulgel for topical delivery for the management of rheumatic arthritis

Drug Development and Industrial Pharmacy

Nano Architect-Based Targeted Delivery Systems for Diabetic Nephropathy: A Review

Current Drug Targets

: Diabetes mellitus is a long-lasting disease that is very common in the age group above 20 years... more : Diabetes mellitus is a long-lasting disease that is very common in the age group above 20 years and is characterized by hyperglycemia with other complications like Diabetic Nephropathy (DN). The management of DN focuses on mainly four regions: reduction of cardiovascular risks, control of blood glycemic levels, control of the blood pressure (BP) profile, and the use of therenin-angiotensin system (RAS). Although BP management and RAS-acting agents can postpone the onset of DN, they cannot prevent it. In the modern era, nanotechnological interventions have spread rapidly in the field of medicine. Patient defiance is considered important in diabetes management when long-term or continuous management is required. Nano pharmaceuticals have been shown to increase compliance of diabetic patients by providing multiple ways of drug delivery, controlling release profile, increasing biological steadiness, targeting efficacy, and decreasing toxic profile. Nanoscale formulations of botanical antidiabetic molecules improve clinical efficacy and treatment compliance by overcoming associated biopharmaceutical and pharmacokinetic barriers. Therefore, the development of nanopharmaceuticals can be considered to be a possible answer to attain the finest scientific effect of the plant-based anti-diabetic molecule. Nevertheless, further studies are needed to create clinical research-based and therapeutically effective nanoforms of antidiabetic plant-based molecules to combat the most dreaded disease of diabetes and its known present complications.

Traditional uses and Phytochemistry of Cinnamomum Species – A Mini Review

Research Journal of Pharmacy and Technology

The genus Cinnamomum, the evergreen tree of tropical and subtropical Asia, Australia, the pacific... more The genus Cinnamomum, the evergreen tree of tropical and subtropical Asia, Australia, the pacific region and South America, a member of family Lauraceae, has been used in day to day routine as a spice and condiment in India. This genus has many applications in perfumery, flavouring and pharmaceutical industries. Volatile oils from different parts of cinnamon such as leaves, fruits, root bark, flowers and buds have been isolated by several techniques and identification of these constituents have been done by GC and GC-MS. The present review describes the traditional and ethanobotanical uses and various chemical constituents, of various Indian species of Cinnamomum genus. This review will help those people who are interested in doing research work on this plant in future, which has got tremendous potential medicinally.

Physiological Pathway, diagnosis and nanotechnology based treatment strategies for ovarian Cancer: A review

Medicine in Omics

Artificial intelligence and data science in pharmacogenomics-based drug discovery: Future of medicines

Elsevier eBooks, 2023

Utilization of kinase inhibitors as novel therapeutic drug targets: A review

Oncology Research

Design expert assisted formulation, characterization and optimization of microemulsion based solid lipid nanoparticles of repaglinide

Progress in Biomaterials

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Rheumatoid Arthritis and JAK-STAT Inhibitors: Prospects of Topical Delivery

Current Drug Therapy

: Rheumatoid arthritis (RA) is the most common musculoskeletal disease in the world. The clinical... more : Rheumatoid arthritis (RA) is the most common musculoskeletal disease in the world. The clinical prospects have increased tremendously since the advent of biological agents as therapy options. NSAIDs such as indomethacin, celecoxib, and etoricoxib are used often in the treatment of RA but off-target effects decreased their use. DMARDs such as methotrexate and etanercept were also effective in the treatment of RA, but tolerance to methotrexate developed in many cases. Janus kinase inhibitors (JAKi) have also gained popularity as a treatment option for rheumatoid arthritis. Tofacitinib is the foremost JAK inhibitor that is used to treat RA as an individual agent or in combination with other DMARDs. The most frequently used route of administration for JAKi is oral. Since oral formulations of JAK inhibitors have a number of health hazards, such as systemic toxicity and patient noncompliance, topical formulations of JAK inhibitors have emerged as a preferable alternative for administering JAK inhibitors. Tofacitinib delivered topically, seems to have the potential to eliminate or reduce the occurrences of negative effects when compared to tofacitinib taken orally. Given the scarcity of knowledge on the techniques for topical distribution of JAKi, more effort will be required to develop a stable topical formulation of JAKi to address the limitations of oral route. The current review looks at JAK inhibitors and the ways that have been used to generate topical formulations of them.

Innovation in cancer therapeutics and regulatory perspectives

Medical Oncology

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DoE Based Formulation Development and Characterization of Topical Nanoemulgel of Diacerein: In-Vitro Release and Permeation Studies

BioNanoScience

Supplemental Material, Graphical_Abstract - Unwinding Complexities of Diabetic Alzheimer by Potent Novel Molecules

Supplemental Material, Graphical_Abstract for Unwinding Complexities of Diabetic Alzheimer by Pot... more

Pathophysiology of Alzheimer Disease: Current Drug Therapy

Alzheimer&#39;s disease (AD) is a neurodegenerative age related disease in which patients of ... more Alzheimer&#39;s disease (AD) is a neurodegenerative age related disease in which patients of age 65 or more suffer from memory impairment problems. This disease is related to the nervous system degradation and various pathophysiological conditions have been identified such as formation of β-amyloid and plaques, nerve degeneration, neurotransmitter depletion, accumulation of toxins, oxidative stress and inflammation. Local RAS system in the brain is different from vascular RAS and play an important role in pathophysiology of AD. RAS system modulates inflammatory processes, neurotransmitter activity and amyloid and plaque formation. Angiotensin II, a vasoconstriction peptide of RAS system also induces neuronal cell loss by the process of cell senescence. Genetic polymorphism is also an important factor for pathophysiology and treatment of AD. No treatment is available which can eradicate AD completely; only prophylactic treatments are available which gives only prophylactic relief. Treatments are given which improve the pathophysiological condition of the disease and restore the brain cells activity. Treatment approach includes prevention of β amyloid and plaque formation, restoration of neurotransmitter system, prevention of oxidative stress and inflammation. Other than allopathic medicines, traditional system of medicines also have number of herbs and plants which have the property of learning and memory improvement via different mechanism of actions.

Quality by design (QbD) approach of pharmacogenomics in drug designing and formulation development for optimization of drug delivery systems

Journal of controlled release : official journal of the Controlled Release Society, Jan 10, 2017

Conventional approaches of drug discovery are very complex, costly and time consuming. But after ... more Conventional approaches of drug discovery are very complex, costly and time consuming. But after the completion of human genome project, applications of pharmacogenomics in this area completely revolutionize the drug discovery and development process to produce a quality by design (QbD) approach based products. The applications of two areas of pharmacogenomics i.e. structural and functional pharmacogenomics excel the drug discovery process by employing genomic data in drug target identification and evaluation, lead optimization via high throughput screening, evaluation of drug metabolizing enzymes, drug transporters and drug receptors using computer aided technique and bioinformatics library data base. Pharmacogenomics also provides an important and reliable basis for evaluation and optimization of the dosage forms as well as repositioning of failed drugs for the treatment of new disease. Various dosage forms of category of drugs such as anticancer drugs, vaccines, gene and DNA deli...

Recent Advances in Permeation Enhancement Techniques for Transdermal Drug Delivery Systems: A Review

Current Drug Therapy, 2014

ABSTRACT Transdermal route is preferred due to its numerous advantages over other routes. Stratum... more ABSTRACT Transdermal route is preferred due to its numerous advantages over other routes. Stratum corneum and other skin layers are the foremost obstacles in employing skin as a drug delivery route. So various penetration enhancement techniques are utilized which cause the delivery of drug through the skin in proper amounts and at a predetermined rate. Permeation enhancers are the agents which do not have any therapeutic activity themselves but these increase the permeability of drug through the skin. Numerous chemical agents from natural and synthetic origins are evaluated for their penetration enhancement ability. Other than chemical agents, various novel drug delivery systems such as nanoparticles, liposomes, niosomes, transferosomes and ethosomes etc; and various physical means of skin ablaze are also useful for drug penetration through skin. The focus of this review is to discuss various permeation enhancement techniques for effective delivery of drugs through skin.

Induction of Type 2 Diabetes Mellitus with Antihypertensive Therapy: Is There Any Role of Alpha Adducin, ACE, and IRS-1 Gene?

Value in health regional issues, 2017

Hypertension and diabetes are related disorders that share common pathophysiological pathways and... more Hypertension and diabetes are related disorders that share common pathophysiological pathways and occur together. Although hypertension itself is a risk factor for developing diabetes, prolonged use of first-line antihypertensive therapy has also been reported to induce diabetes. Genetic polymorphism of genes affecting salt sensitivity and insulin resistance can have a role in antihypertensive therapy-induced diabetes. Polymorphism of the alpha adducin gene, angiotensin-converting enzyme gene, and insulin receptor substrate 1 gene has been found to be associated with new incident diabetes in hypertensive patients via salt sensitivity and insulin resistance. Many studies have, however, revealed a negative correlation with this hypothesis and have shown no role of antihypertensive therapy in diabetes induction. Therefore, more detailed experimental studies are needed to reach a final conclusion.

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Formulation and Quality Control Tests for Nanoemulsion of Tofacitinib: A Novel Approach

Journal of Pharmaceutical Research International, 2021

Background: Tofacitinib (TFB) is a pioneer JAK (Janus kinase) inhibitor mainly employed to treat ... more Background: Tofacitinib (TFB) is a pioneer JAK (Janus kinase) inhibitor mainly employed to treat rheumatoid arthritis. It has proven efficacy for the treatment of rheumatoid arthritis in the oral dosage form. Oral TFB exhibited several toxic effects. Current research aims to develop a topical formulation of TFB to achieve effective treatment without any adverse effects. Study Design: Ultrsonication Methods. Place and Duration of Study: Sample: Swami Dayanand Postgraduate Institute of Pharmaceuticals Sciences, University of Health Sciences, Rohtak; 2020-2021. Methods: Oleic acid, tween 80, and propylene glycol were selected as oil, surfactant, and co-surfactant, respectively. The ratio of oil:surfactant:co-surfactant was selected based on a ternary phase diagram using the aqueous titration method. The selected ratio was employed to develop eight formulations of TFB by ultra-sonication. The formulations (F1-F8) were characterized using several physicochemical methods like pH, viscosit...

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Formulation and evaluation of novel controlled release of topical pluronic lecithin organogel of mefenamic acid

Drug delivery, Jan 5, 2016

In the present study, pluronic lecithin based organogels (PLO gels) were formulated as topical ca... more In the present study, pluronic lecithin based organogels (PLO gels) were formulated as topical carrier for controlled delivery of mefenamic acid. Ten organogel formulations were prepared by a method employing lecithin as lipophilic phase and pluronic F-127 as hydrophilic phase in varying concentrations to study various parameters using in vitro diffusion study and in vivo studies. All formulations were found to be off-white, homogenous, and reluctant to be washed easily and have pH value within the range of 5.56-5.80 which is nonirritant. Polymer concentration increased in formulations of F1 to F5 (lecithin) and F6 to F10 (pluronic) resulted in decrease of the gelation temperature, increase of viscosity and reduction of spreadability of gels having polymer tendency to form rigid 3D network. Organogels with higher viscosity were found to be more stable and retard the drug release from the gel. The formulations of F2 and F3 were selected for kinetic studies and stability studies, as t...

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Alpha adducin (ADD1) gene polymorphism and new onset of diabetes under the influence of selective antihypertensive therapy in essential hypertension

Current hypertension reviews, Jan 30, 2018

Different antihypertensive therapies (especially diuretics) are reported to induce new onset of d... more Different antihypertensive therapies (especially diuretics) are reported to induce new onset of diabetes in some hypertensive patients. α-adducin-1 (ADD1) gene is salt sensitive gene which has its role in etiology of hypertension via salt sensitivity. Therefore, the G460T polymorphism of ADD1 gene may be associated with new onset of diabetes under the influence of diuretic and other antihypertensive therapies. To assess the correlation between genetic polymorphism (ADD1 G460T polymorphism) and glycaemic disturbance under influence of diuretic and other antihypertensive drug therapies. We recruited study subjects, 270 normotensive as control (150 male and 120 females), 270 hypertensive patients (95 male and 175 females) and 240 hypertensive with new onset of diabetes patients (80 male and 160 females). All study samples were genotyped for ADD1 polymorphic alleles and analyzed the relationship between different genotypes with respect to anthropometric and clinical parameters along wit...

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