(Q34770609)

4 August 2017

1 reference

title

5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy (English)

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4 August 2017

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Judith K Christman

1

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4 August 2017

language of work or name

English

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publication date

1 August 2002

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4 August 2017

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4 August 2017

volume

21

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4 August 2017

issue

35

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4 August 2017

page(s)

5483-5495

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The PHD finger: implications for chromatin-mediated transcriptional regulation

4 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

5-azaC treatment enhances expression of transforming growth factor-beta receptors through down-regulation of Sp3.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Enzymatic properties of de novo-type mouse DNA (cytosine-5) methyltransferases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Methylation of conserved CpG sites neighboring the beta retinoic acid response element may mediate retinoic acid receptor beta gene silencing in MCF-7 breast cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

RASSF1A promoter region CpG island hypermethylation in phaeochromocytomas and neuroblastoma tumours

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Gametic imprinting in mammals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Isolation, characterization, and properties of a labile hydrolysis product of the antitumor nucleoside, 5-azacytidine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Genetic analysis of the 5-azacytidine sensitivity of Escherichia coli K-12.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

CpG-rich islands and the function of DNA methylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Optimization of baculovirus-mediated expression and purification of hexahistidine-tagged murine DNA (cytosine-C5)-methyltransferase-1 in Spodoptera frugiperda 9 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

AdoMet-dependent methylation, DNA methyltransferases and base flipping

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Correlation between Hypomethylation of DNA and Expression of Globin Genes in Friend Erythroleukemia Cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Reversibility of changes in nucleic acid methylation and gene expression induced in rat liver by severe dietary methyl deficiency.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

5-Methyl-2'-deoxycytidine in single-stranded DNA can act in cis to signal de novo DNA methylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21 WAF1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Biological effects of 5-azacytidine in eukaryotes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Functional striated muscle cells from non-myoblast precursors following 5-azacytidine treatment

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Cytotoxicity of 5-aza-2'-deoxycytidine in a mammalian cell system

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Alterations in expression and methylation of specific genes in livers of rats fed a cancer promoting methyl-deficient diet

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

The candidate tumor suppressor gene, RASSF1A, from human chromosome 3p21.3 is involved in kidney tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Studies on the hypomethylation of c-myc, c-Ha-ras oncogenes and histopathological changes in human gastric carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Hypomethylation of ras oncogenes in primary human cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Alterations in DNA methylation in human colon neoplasia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

DNA methylation in 5-aza-2'-deoxycytidine-resistant variants of C3H 10T1/2 C18 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Binding of the EcoRII methylase to azacytosine-containing DNA.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

DNA methyltransferase Dnmt1 associates with histone deacetylase activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

The mechanism of inhibition of DNA (cytosine-5-)-methyltransferases by 5-azacytosine is likely to involve methyl transfer to the inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

The 5-methylcytosine content of DNA from human tumors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Synthesis of oligonucleotide inhibitors of DNA (Cytosine-C5) methyltransferase containing 5-azacytosine residues at specific sites

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

The induction of liver cancer by dietary deficiency of choline and methionine without added carcinogens

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Hypomethylation of DNA from benign and malignant human colon neoplasms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Enzymatic properties of recombinant Dnmt3a DNA methyltransferase from mouse: the enzyme modifies DNA in a non-processive manner and also methylates non-CpG [correction of non-CpA] sites

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Regulation of the intestinal mucin MUC2 gene expression in vivo: evidence for the role of promoter methylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Structure and Methylation-Based Silencing of a Gene (DBCCR1) within a Candidate Bladder Cancer Tumor Suppressor Region at 9q32–q33

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Modulation of Igf2 Genomic Imprinting in Mice Induced by 5-Azacytidine, an Inhibitor of DNA Methylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Mutagenicity of 5-aza-2'-deoxycytidine is mediated by the mammalian DNA methyltransferase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Methylation-mediated regulation of the glutathione S-transferase P1 gene in human breast cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

The DNA methylation paradox

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Cellular differentiation, cytidine analogs and DNA methylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

De novo methylation of the MyoD1 CpG island during the establishment of immortal cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Chromatid breakage: differential effect of inhibitors of DNA synthesis during G 2 phase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Activation of the p53 DNA damage response pathway after inhibition of DNA methyltransferase by 5-aza-2'-deoxycytidine.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

HhaI methyltransferase flips its target base out of the DNA helix

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

M.HhaI binds tightly to substrates containing mismatches at the target base

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Dynamic modes of the flipped-out cytosine during HhaI methyltransferase-DNA interactions in solution.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

5-Methylcytosine content of nuclear DNA during chemical hepatocarcinogenesis and in carcinomas which result

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

DNA methylation and methylase levels in normal and malignant mouse hepatic tissues

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Cytosine-specific type II DNA methyltransferases. A conserved enzyme core with variable target-recognizing domains

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Inhibition of protein synthesis in 5-azacytidine-treated HeLa cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Alterations of p16INK4A and p15INK4B genes in gastric carcinomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Methylation and silencing of the Thrombospondin-1 promoter in human cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Enhancement of 2-acetylaminofluorene liver carcinogenesis in rats fed a choline-devoid diet

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

TFT and 6TG resistance of mouse lymphoma cells to analogs of azacytidine.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

The DNA binding affinity of HhaI methylase is increased by a single amino acid substitution in the catalytic center

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Hepatocarcinogenesis in rats fed methyl-deficient, amino acid-defined diets

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

5-Azacytidine-induced recovery of O6-alkylguanine--DNA alkyltransferase activity in mouse Ha821 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Pilot phase I-II study on 5-aza-2'-deoxycytidine (Decitabine) in patients with metastatic lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Expression of GPC3, an X-linked recessive overgrowth gene, is silenced in malignant mesothelioma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Labile methyl groups and the promotion of cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Susceptibility of nonpromoter CpG islands to de novo methylation in normal and neoplastic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Enzymatic C5-cytosine methylation of DNA: mechanistic implications of new crystal structures for HhaL methyltransferase-DNA-AdoHcy complexes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

A structural basis for the preferential binding of hemimethylated DNA by HhaI DNA methyltransferase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Structure of a binary complex of HhaI methyltransferase with S-adenosyl-L-methionine formed in the presence of a short non-specific DNA oligonucleotide

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Molecular cloning and characterization of annexin V-binding proteins with highly hydrophilic peptide structure

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Reduction of p53 gene expression in human primary hepatocellular carcinoma is associated with promoter region methylation without coding region mutation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Predictive motifs derived from cytosine methyltransferases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

DNA methylation, methyltransferases, and cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

DNA methylation in health and disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

PAX6 methylation and ectopic expression in human tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Silencing of the CD44 gene by CpG methylation in a human gastric carcinoma cell line

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Epigenetic regulation of the KAI1 metastasis suppressor gene in human prostate cancer cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Patterns of methylation of the c-myc gene in human colorectal cancer progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Mechanism of inhibition of DNA (cytosine C5)-methyltransferases by oligodeoxyribonucleotides containing 5,6-dihydro-5-azacytosine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Tissue levels of S-adenosylmethionine and S-adenosylhomocysteine in rats fed methyl-deficient, amino acid-defined diets for one to five weeks.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

5-Azacytidine, a new, highly effective cancerostatic

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Mechanism of action of eukaryotic DNA methyltransferase. Use of 5-azacytosine-containing DNA

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Segmentation of human chromosomes induced by 5-ACR (5-azacytidine)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Use of Oligodeoxyribonucleotides with Conformationally Constrained Abasic Sugar Targets To Probe the Mechanism of Base Flipping byHhaI DNA (Cytosine C5)-methyltransferase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Inhibition of ribosomal ribonucleic acid maturation by 5-azacytidine and 8-azaguanine in Novikoff hepatoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

DNA methylation decreases in aging but not in immortal cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Transcriptional regulation of urokinase (uPA) gene expression in breast cancer cells: role of DNA methylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

HhaI and HpaII DNA methyltransferases bind DNA mismatches, methylate uracil and block DNA repair

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Mammalian DNA cytosine-5 methyltransferase interacts with p23 protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Genetic and epigenetic aspects of DNA methylation on genome expression, evolution, mutation and carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205699

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205699

1 reference

Dimensions Publication ID

4 August 2017

1015413259

0 references

1 reference