(Q28237319)

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Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome

scientific article (publication date: May 1997)

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Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome (English)

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author name string

D J Smith

1

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M E Stevens

2

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S P Sudanagunta

3

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R T Bronson

4

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M Makhinson

5

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A M Watabe

6

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T J O'Dell

7

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J Fung

8

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H U Weier

9

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J F Cheng

10

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E M Rubin

11

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language of work or name

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publication date

May 1997

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Nature Genetics

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16

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1

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28-36

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A comprehensive genetic map of the human genome based on 5,264 microsatellites

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21 April 2017

A synaptic model of memory: long-term potentiation in the hippocampus

1 reference

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21 April 2017

A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region

1 reference

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21 April 2017

Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII

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21 April 2017

A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation

1 reference

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21 April 2017

Cloning of a human homolog of the Drosophila minibrain/rat Dyrk gene from "the Down syndrome critical region" of chromosome 21

1 reference

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21 April 2017

Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome "critical region"

1 reference

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21 April 2017

Genetic analysis of autoimmune disease

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21 January 2018

A comprehensive genetic map of the mouse genome.

1 reference

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21 January 2018

A mouse model for Down syndrome exhibits learning and behaviour deficits.

1 reference

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21 January 2018

Construction of a panel of transgenic mice containing a contiguous 2-Mb set of YAC/P1 clones from human chromosome 21q22.2.

1 reference

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21 January 2018

Cyclin D1 provides a link between development and oncogenesis in the retina and breast

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21 January 2018

Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase

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21 January 2018

Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins

1 reference

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21 January 2018

Synaptic plasticity: LTP and LTD.

1 reference

https://api.crossref.org/works/10.1038%2FNG0597-28

21 January 2018

Isolation and mapping of human chromosome 21 cDNA: progress in constructing a chromosome 21 expression map.

1 reference

https://api.crossref.org/works/10.1038%2FNG0597-28

21 January 2018

Abnormally high neuronal density in the schizophrenic cortex. A morphometric analysis of prefrontal area 9 and occipital area 17.

1 reference

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21 January 2018

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro.

1 reference

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21 January 2018

Functional inactivation of genes by dominant negative mutations

1 reference

https://api.crossref.org/works/10.1038%2FNG0597-28

21 January 2018

Spatial mapping: definitive disruption by hippocampal or medial frontal cortical damage in the rat.

1 reference

https://api.crossref.org/works/10.1038%2FNG0597-28

21 January 2018

Continuum of overlapping clones spanning the entire human chromosome 21q.

1 reference

https://api.crossref.org/works/10.1038%2FNG0597-28

21 January 2018

Genetic dissection of complex traits

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https://api.crossref.org/works/10.1038%2FNG0597-28

7 January 2021

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Down syndrome phenotypes: the consequences of chromosomal imbalance

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https://api.crossref.org/works/10.1038%2FNG0597-28

7 January 2021

based on heuristic

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Critical role of the D21S55 region on chromosome 21 in the pathogenesis of Down syndrome

1 reference

https://api.crossref.org/works/10.1038%2FNG0597-28

7 January 2021

based on heuristic

inferred from DOI database lookup

PKC gamma mutant mice exhibit mild deficits in spatial and contextual learning.

1 reference

https://api.crossref.org/works/10.1038%2FNG0597-28

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of a nonsense mutation in the rod photoreceptor cGMP phosphodiesterase beta-subunit gene of the rd mouse

1 reference

https://api.crossref.org/works/10.1038%2FNG0597-28

7 January 2021

based on heuristic

inferred from DOI database lookup

RETINAL DEGENERATION IN THE MOUSE: LOCATION OF THE RD LOCUS IN LINKAGE GROUP XVII

1 reference

https://api.crossref.org/works/10.1038%2FNG0597-28

7 January 2021

based on heuristic

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Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans

1 reference

https://api.crossref.org/works/10.1038%2FNG0597-28

7 January 2021

based on heuristic

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Place navigation impaired in rats with hippocampal lesions

1 reference

https://api.crossref.org/works/10.1038%2FNG0597-28

7 January 2021

based on heuristic

inferred from DOI database lookup

Modified hippocampal long-term potentiation in PKCγ-mutant mice

1 reference

https://api.crossref.org/works/10.1038%2FNG0597-28

7 January 2021

based on heuristic

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CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP

1 reference

https://api.crossref.org/works/10.1038%2FNG0597-28

7 January 2021

based on heuristic

inferred from DOI database lookup

A transcript map of the Down syndrome critical region on chromosome 21.

1 reference

https://api.crossref.org/works/10.1038%2FNG0597-28

7 January 2021

based on heuristic

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minibrain: a new protein kinase family involved in postembryonic neurogenesis in Drosophila

1 reference

https://api.crossref.org/works/10.1038%2FNG0597-28

7 January 2021

based on heuristic

inferred from DOI database lookup

Pervasive neuroanatomic abnormalities of the brain in three cases of Rett's syndrome

1 reference

https://api.crossref.org/works/10.1038%2FNG0597-28

7 January 2021

based on heuristic

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Neurobiology of Rett syndrome

1 reference

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7 January 2021

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inferred from DOI database lookup

Influence of PAX6 gene dosage on development: overexpression causes severe eye abnormalities

1 reference

https://api.crossref.org/works/10.1038%2FNG0597-28

7 January 2021

based on heuristic

inferred from DOI database lookup

Gene identification in 1.6-Mb region of the Down syndrome region on chromosome 21

1 reference

https://api.crossref.org/works/10.1038%2FNG0597-28

7 January 2021

based on heuristic

inferred from DOI database lookup

Quantitative DNA fiber mapping

1 reference

https://api.crossref.org/works/10.1038%2FNG0597-28

7 January 2021

based on heuristic

inferred from DOI database lookup

Spatial localization does not require the presence of local cues

1 reference

https://api.crossref.org/works/10.1038%2FNG0597-28

7 January 2021

based on heuristic

inferred from DOI database lookup

Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice

1 reference

https://api.crossref.org/works/10.1038%2FNG0597-28

7 January 2021

based on heuristic

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Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

1 reference

https://api.crossref.org/works/10.1038%2FNG0597-28

7 January 2021

based on heuristic

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Linkage and sequence conservation of the X-linked genes DXS253E (P3) and DXS254E (GdX) in mouse and man.

1 reference

https://api.crossref.org/works/10.1038%2FNG0597-28

7 January 2021

based on heuristic

inferred from DOI database lookup

A "housekeeping" gene on the X chromosome encodes a protein similar to ubiquitin

1 reference

https://api.crossref.org/works/10.1038%2FNG0597-28

7 January 2021

based on heuristic

inferred from DOI database lookup

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10.1038/NG0597-28

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