(Q28573499)

English

Insulin activates hypoxia-inducible factor-1alpha in human and rat vascular smooth muscle cells via phosphatidylinositol-3 kinase and mitogen-activated protein kinase pathways: impairment in insulin resistance owing to defects in insulin signalling

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PubMed publication ID

31 January 2017

Insulin activates hypoxia-inducible factor-1alpha in human and rat vascular smooth muscle cells via phosphatidylinositol-3 kinase and mitogen-activated protein kinase pathways: impairment in insulin resistance owing to defects in insulin signalling (English)

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PubMed publication ID

31 January 2017

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insulin resistance

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author name string

G. Doronzo

1

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PubMed publication ID

31 January 2017

I. Russo

2

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PubMed publication ID

31 January 2017

L. Mattiello

3

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PubMed publication ID

31 January 2017

C. Riganti

4

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PubMed publication ID

31 January 2017

G. Anfossi

5

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PubMed publication ID

31 January 2017

M. Trovati

6

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PubMed publication ID

31 January 2017

publication date

1 May 2006

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PubMed publication ID

31 January 2017

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PubMed publication ID

31 January 2017

49

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PubMed publication ID

31 January 2017

5

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PubMed publication ID

31 January 2017

1049–1063

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PubMed publication ID

31 January 2017

Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1alpha and VEGF.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-006-0156-0

21 January 2018

Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes

1 reference

https://api.crossref.org/works/10.1007%2FS00125-006-0156-0

21 January 2018

Influence of coronary collateral vessels on myocardial infarct size in humans. Results of phase I thrombolysis in myocardial infarction (TIMI) trial. The TIMI Investigators

1 reference

https://api.crossref.org/works/10.1007%2FS00125-006-0156-0

21 January 2018

Molecular mechanisms of insulin resistance that impact cardiovascular biology

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective insulin resistance affecting nitric oxide release but not plasminogen activator inhibitor-1 synthesis in fibroblasts from insulin-resistant individuals.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene therapy for ischemic cardiovascular diseases: some lessons learned from the first clinical trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathophysiology of collateral development

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

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Normoxic induction of the hypoxia-inducible factor 1alpha by insulin and interleukin-1beta involves the phosphatidylinositol 3-kinase pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

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Human vascular smooth muscle cells express a constitutive nitric oxide synthase that insulin rapidly activates, thus increasing guanosine 3':5'-cyclic monophosphate and adenosine 3':5'-cyclic monophosphate concentrations

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

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Regulation of hypoxia-inducible factor (HIF)-1 activity and expression of HIF hydroxylases in response to insulin-like growth factor I.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

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Influence of obesity on cardiovascular risk. Twenty-three-year follow-up of 22,025 men from an urban Swedish population

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coordinated activation of VEGFR-1 and VEGFR-2 is a potent arteriogenic stimulus leading to enhancement of regional perfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

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Insulin resistance in spontaneously hypertensive rats is associated with endothelial dysfunction characterized by imbalance between NO and ET-1 production.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

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Autologous vascular smooth muscle cell-based myocardial gene therapy to induce coronary collateral growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

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Insulin activates vascular endothelial growth factor in vascular smooth muscle cells: influence of nitric oxide and of insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

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The cross-talk between angiotensin and insulin differentially affects phosphatidylinositol 3-kinase- and mitogen-activated protein kinase-mediated signaling in rat heart: implications for insulin resistance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

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Effects of insulin, contraction, and phorbol esters on mitogen-activated protein kinase signaling in skeletal muscle from lean and ob/ob mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coronary collateral circulation: clinical significance and influence on survival in patients with coronary artery occlusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

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Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatocyte growth factor signaling regulates transactivation of genes belonging to the plasminogen activation system via hypoxia inducible factor-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

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Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

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Exercise training increases ERK2 activity in skeletal muscle of obese Zucker rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

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HIF-1: mediator of physiological and pathophysiological responses to hypoxia

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of angiogenesis and arteriogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Obesity is associated with impaired coronary collateral vessel development

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vascular oxidant stress enhances progression and angiogenesis of experimental atheroma

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of growth-related metabolism in human vascular smooth muscle cells by low density lipoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of vascular endothelial growth factor in regulation of physiological angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

c-Jun NH2-terminal kinase activation contributes to hypoxia-inducible factor 1alpha-dependent P-glycoprotein expression in hypoxia

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic States: a possible explanation for impaired collateral formation in cardiac tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth factor signal transduction defects in the cardiovascular system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced basal activation of mitogen-activated protein kinases in adipocytes from type 2 diabetes: potential role of p38 in the downregulation of GLUT4 expression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of hypoxia-inducible factor-1alpha by transcriptional and translational mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Paradoxical effects of iron chelation on growth of vascular endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of angiogenesis by hypoxia: role of the HIF system

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Re-evaluating therapeutic neovascularization

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin Affects Vascular Smooth Muscle Cell Phenotype and Migration Via Distinct Signaling Pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/16506055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00125-006-0156-0

1 reference

PubMed publication ID

31 January 2017

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PubMed publication ID

1 reference

PubMed publication ID

31 January 2017

ResearchGate publication ID

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