(Q288797)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P28222

G protein-coupled receptor

1 reference

Transporter Classification Database ID

9.A.14.3.6

hierarchical database ID heuristic

2 October 2019

based on heuristic

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

signal transducer activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28222&geneProductId=UniProtKB:P28222

1 reference

1 January 2018

G protein-coupled serotonin receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28222&geneProductId=UniProtKB:P28222

3 references

16 July 2018

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28222&geneProductId=UniProtKB:P28222

16 July 2018

Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: A homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28222&geneProductId=UniProtKB:P28222

neurotransmitter receptor activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

serotonin binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

G protein-coupled receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

G protein-coupled serotonin receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

8 April 2019

Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: A homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

cell component

cytoplasm

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

1 reference

8 April 2019

integral component of plasma membrane

Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28222&geneProductId=UniProtKB:P28222

16 July 2018

Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: A homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28222&geneProductId=UniProtKB:P28222

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28222&geneProductId=UniProtKB:P28222

16 July 2018

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

8 April 2019

calyx of Held

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

integral component of presynaptic membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

serotonergic synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

integral component of plasma membrane

Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

8 April 2019

Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: A homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

dendrite

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

chemical synaptic transmission

biological process

A human serotonin 1D receptor variant (5HT1D beta) encoded by an intronless gene on chromosome 6

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28222&geneProductId=UniProtKB:P28222

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28222&geneProductId=UniProtKB:P28222

16 July 2018

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28222&geneProductId=UniProtKB:P28222

G protein-coupled receptor internalization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

regulation of dopamine secretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

regulation of behavior

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

1 reference

8 April 2019

response to mineralocorticoid

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

vasoconstriction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

1 reference

8 April 2019

adenylate cyclase-inhibiting serotonin receptor signaling pathway

1 reference

8 April 2019

Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: A homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

1 reference

16 July 2018

Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28222&geneProductId=UniProtKB:P28222

cellular response to alkaloid

1 reference

8 April 2019

Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: A homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

cellular response to temperature stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

negative regulation of synaptic transmission, GABAergic

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

protein kinase C-activating G protein-coupled receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

drinking behavior

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

feeding behavior

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

response to ethanol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

negative regulation of synaptic transmission, glutamatergic

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

1 reference

8 April 2019

response to cocaine

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

positive regulation of vascular associated smooth muscle cell proliferation

IMP

1 reference

8 April 2019

A Sex-Specific MicroRNA-96/5-Hydroxytryptamine 1B Axis Influences Development of Pulmonary Hypertension

GOA

curator

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

G protein-coupled receptor signaling pathway

IMP

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

1 reference

8 April 2019

5-HT2B receptor-mediated calcium release from ryanodine-sensitive intracellular stores in human pulmonary artery endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

animal behaviour

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

1 reference

8 April 2019

presynaptic modulation of chemical synaptic transmission

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

regulation of synaptic vesicle exocytosis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

chemical synaptic transmission

A human serotonin 1D receptor variant (5HT1D beta) encoded by an intronless gene on chromosome 6

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

regulation of presynaptic cytosolic calcium ion concentration

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28222

physically interacts with

1 reference

7191

17 August 2016

1 reference

3

17 August 2016

1 reference

218

17 August 2016

5-carboxamidotryptamine

1 reference

4

17 August 2016

1 reference

5

17 August 2016

1 reference

107

17 August 2016

5-(nonyloxy)-tryptamine

1 reference

106

(+/-)-8-hydroxy-2-(di-N-propylamino)tetralin

17 August 2016

2 references

7

17 August 2016

31

17 August 2016

2 references

120

17 August 2016

117

17 August 2016

1 reference

34

17 August 2016

1 reference

37

17 August 2016

1 reference

109

17 August 2016

1 reference

38

17 August 2016

1 reference

110

17 August 2016

1 reference

3221

17 August 2016

1 reference

121

17 August 2016

1 reference

39

17 August 2016

1 reference

40

17 August 2016

1 reference

123

17 August 2016

1 reference

47

17 August 2016

1 reference

124

17 August 2016

1 reference

48

17 August 2016

1 reference

23

1-(3-trifluoromethylphenyl)piperazine

17 August 2016

1 reference

115

17 August 2016

1 reference

125

17 August 2016

1 reference

57

17 August 2016

1 reference

59

17 August 2016

1 reference

10

17 August 2016

1 reference

35

17 August 2016

1 reference

14

17 August 2016

1 reference

43

17 August 2016

1 reference

45

17 August 2016

1 reference

51

17 August 2016

1 reference

52

17 August 2016

1 reference

28

17 August 2016

1 reference

54

17 August 2016

1 reference

56

17 August 2016

1 reference

7351

17 August 2016

1 reference

60

17 August 2016

1 reference

88

17 August 2016

1 reference

133

17 August 2016

1 reference

134

17 August 2016

1 reference

46

17 August 2016

1 reference

92

17 August 2016

1 reference

136

17 August 2016

1 reference

96

17 August 2016

1 reference

97

17 August 2016

1 reference

98

17 August 2016

1 reference

102

17 August 2016

1 reference

103

17 August 2016

1 reference

89

17 August 2016

1 reference

3231

17 August 2016

sumatriptan succinate

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201150

donitriptan

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1742428

zimeldine

antagonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL37744

rizatriptan

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL905

zolmitriptan

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1185

naratriptan hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200601

Gene Atlas image

PBB GE HTR1B 210799 at fs.png
732 × 530; 11 KB

0 references

exact match

http://purl.uniprot.org/uniprot/P28222

1 reference

GPCR, rhodopsin-like, 7TM

Identifiers.org

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P28222

Identifiers

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

28 October 2013

1 reference

9 August 2016

1 reference

9 August 2016

Transporter Classification Database ID

9.A.14.3.6

2 references

Transporter Classification database

13 March 2020

Transporter Classification database