(Q33590019)

28 July 2017

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title

Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau. (English)

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28 July 2017

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Hardy J

1

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28 July 2017

Duff K

2

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28 July 2017

Hardy KG

3

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28 July 2017

Perez-Tur J

4

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28 July 2017

Hutton M

5

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28 July 2017

language of work or name

English

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publication date

1 September 1998

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28 July 2017

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28 July 2017

volume

1

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28 July 2017

issue

5

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28 July 2017

page(s)

355-358

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Amyloid deposition as the central event in the aetiology of Alzheimer's disease

28 July 2017

cites work

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Amyloid beta-protein and the genetics of Alzheimer's disease

21 January 2018

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Amyloid, the presenilins and Alzheimer's disease

21 January 2018

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

21 January 2018

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

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Candidate gene for the chromosome 1 familial Alzheimer's disease locus

21 January 2018

1 reference

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

21 January 2018

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Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

21 January 2018

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Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

21 January 2018

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An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

21 January 2018

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

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Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

21 January 2018

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Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

21 January 2018

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

21 January 2018

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Increased Abeta42(43) from cell lines expressing presenilin 1 mutations.

21 January 2018

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Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

21 January 2018

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Amyloid beta protein (Abeta) deposition in chromosome 14-linked Alzheimer's disease: predominance of Abeta42(43).

21 January 2018

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The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology

21 January 2018

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Age, neurofibrillary changes, A beta-amyloid and the onset of Alzheimer's disease

21 January 2018

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Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

21 January 2018

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

21 January 2018

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Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins

21 January 2018

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Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

21 January 2018

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A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1.

21 January 2018

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Aggregation and disaggregation of senile plaques in Alzheimer disease

21 January 2018

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Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains

21 January 2018

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Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.

21 January 2018

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Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

21 January 2018

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Intracellular A beta 1-42 aggregates stimulate the accumulation of stable, insoluble amyloidogenic fragments of the amyloid precursor protein in transfected cells.

21 January 2018

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Apolipoprotein E affects the rate of Alzheimer disease expression: beta-amyloid burden is a secondary consequence dependent on APOE genotype and duration of disease

21 January 2018

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

21 January 2018

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Alzheimer diseases: a model of gene mutations and susceptibility polymorphisms for complex psychiatric diseases

21 January 2018

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Apolipoprotein E genotype and Alzheimer's disease

21 January 2018

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Epistatic effect of APP717 mutation and apolipoprotein E genotype in familial Alzheimer's disease

21 January 2018

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APOE genotype does not modulate age of onset in families with chromosome 14 encoded Alzheimer's disease.

21 January 2018

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Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition

21 January 2018

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A new polymorphism in the APOE promoter associated with risk of developing Alzheimer's disease.

21 January 2018

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Distortion of allelic expression of apolipoprotein E in Alzheimer's disease.

21 January 2018

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Allelic polymorphisms in the transcriptional regulatory region of apolipoprotein E gene

21 January 2018

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A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia.

21 January 2018

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Structure and novel exons of the human tau gene

21 January 2018

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Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

21 January 2018

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Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans

21 January 2018

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Tau is a candidate gene for chromosome 17 frontotemporal dementia

21 January 2018

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Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

21 January 2018

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Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

21 January 2018

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Autosomal dominant dementia with widespread neurofibrillary tangles.

21 January 2018

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Frontotemporal dementia and parkinsonism linked to chromosome 17: a consensus conference. Conference Participants

21 January 2018

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Vulnerable neuronal subsets in Alzheimer's and Pick's disease are distinguished by their tau isoform distribution and phosphorylation.

21 January 2018

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Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins

21 January 2018

1 reference

7 January 2021

Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse.

1 reference

7 January 2021

Apolipoprotein E epsilon 2 allele promotes longevity and protects patients with Down's syndrome from dementia

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7 January 2021

E280A PS-1 mutation causes Alzheimer's disease but age of onset is not modified by ApoE alleles

1 reference

7 January 2021

Frontotemporal dementia and Parkinsonism linked to chromosome 17: a new group of tauopathies.

1 reference

7 January 2021

Identifiers

DOI

10.1038/1565

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28 July 2017

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