(Q34171694)

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Allosteric activation mechanism of the alpha 1 beta 2 gamma 2 gamma-aminobutyric acid type A receptor revealed by mutation of the conserved M2 leucine

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Europe PubMed Central

PubMed publication ID

31 July 2017

Allosteric activation mechanism of the alpha 1 beta 2 gamma 2 gamma-aminobutyric acid type A receptor revealed by mutation of the conserved M2 leucine (English)

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

author name string

Y Chang

1

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

D S Weiss

2

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Europe PubMed Central

PubMed publication ID

31 July 2017

language of work or name

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publication date

1 November 1999

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Europe PubMed Central

PubMed publication ID

31 July 2017

language of work

Biophysical Journal

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Europe PubMed Central

PubMed publication ID

31 July 2017

77

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

2542-2551

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL

1 reference

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The location of the gate in the acetylcholine receptor channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1300529

5 July 2018

Substitutions of the highly conserved M2 leucine create spontaneously opening rho1 gamma-aminobutyric acid receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1300529

5 July 2018

Neuronally restricted RNA splicing regulates the expression of a novel GABAA receptor subunit conferring atypical functional properties [corrected; erratum to be published]

1 reference

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A novel class of GABAA receptor subunit in tissues of the reproductive system

1 reference

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5 July 2018

Agonist-induced closure of constitutively open gamma-aminobutyric acid channels with mutated M2 domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1300529

5 July 2018

An mRNA encoding a putative GABA-gated chloride channel is expressed in the human cardiac conduction system

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1300529

5 July 2018

https://api.crossref.org/works/10.1016%2FS0006-3495%2899%2977089-X

7 January 2021

Allosteric proteins after thirty years: the binding and state functions of the neuronal alpha 7 nicotinic acetylcholine receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1300529

5 July 2018

Bicuculline and gabazine are allosteric inhibitors of channel opening of the GABAA receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1300529

5 July 2018

Effects of mutating leucine to threonine in the M2 segment of alpha1 and beta1 subunits of GABAA alpha1beta1 receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1300529

5 July 2018

Identification of channel-lining residues in the M2 membrane-spanning segment of the GABA(A) receptor alpha1 subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1300529

5 July 2018

Stoichiometry of a recombinant GABAA receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1300529

5 July 2018

Interaction of picrotoxin with GABAA receptor channel-lining residues probed in cysteine mutants.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1300529

5 July 2018

Cloning of a gamma-aminobutyric acid type C receptor subunit in rat retina with a methionine residue critical for picrotoxinin channel block

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1300529

5 July 2018

A single amino acid in gamma-aminobutyric acid rho 1 receptors affects competitive and noncompetitive components of picrotoxin inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1300529

5 July 2018

Single amino acid substitution affects desensitization of the 5-hydroxytryptamine type 3 receptor expressed in Xenopus oocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1300529

5 July 2018

A point mutation in a Drosophila GABA receptor confers insecticide resistance.

1 reference

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5 July 2018

Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1300529

5 July 2018

Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1300529

5 July 2018

A single point mutation decreases picrotoxinin sensitivity of the human GABA receptor ρ1 subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1300529

5 July 2018

A unique amino acid of the Drosophila GABA receptor with influence on drug sensitivity by two mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1300529

5 July 2018

Quaternary structure of the native GABAA receptor determined by electron microscopic image analysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1300529

5 July 2018

GABAA receptor needs two homologous domains of the beta-subunit for activation by GABA but not by pentobarbital

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1300529

5 July 2018

Spontaneous openings of the acetylcholine receptor channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1300529

5 July 2018

Primary structure of α-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1300529

5 July 2018

On the application of "a plausible model" of allosteric proteins to the receptor for acetylcholine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1300529

5 July 2018

Sequence and functional expression of the GABA A receptor shows a ligand-gated receptor super-family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1300529

5 July 2018

Pharmacology of a novel effect of gamma-aminobutyric acid on the frog optic tectum in vitro.

1 reference

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5 July 2018

A novel alpha subunit in rat brain GABAA receptors

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1300529

5 July 2018

Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology

1 reference

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5 July 2018

Evidence that the M2 membrane-spanning region lines the ion channel pore of the nicotinic receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1300529

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Conserved quaternary structure of ligand-gated ion channels: the postsynaptic glycine receptor is a pentamer

1 reference

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5 July 2018

Kinetics of unliganded acetylcholine receptor channel gating

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1300529

5 July 2018

Molecular biology of GABAA receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1300529

5 July 2018

Pentameric structure and subunit stoichiometry of a neuronal nicotinic acetylcholine receptor

1 reference

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5 July 2018

Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina

1 reference

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5 July 2018

Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor

1 reference

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5 July 2018

Expression of mammalian gamma-aminobutyric acid receptors with distinct pharmacology in Xenopus oocytes

1 reference

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5 July 2018

The effect of subunit composition of rat brain GABAA receptors on channel function

1 reference

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Functional properties of recombinant rat GABAA receptors depend upon subunit composition

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The atypical M2 segment of the beta subunit confers picrotoxinin resistance to inhibitory glycine receptor channels

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Acetylcholine receptor channel structure probed in cysteine-substitution mutants.

1 reference

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Point mutations affecting antagonist affinity and agonist dependent gating of GABAA receptor channels.

1 reference

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DNA sequencing with chain-terminating inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1300529

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Point mutations in the M2 region of the alpha, beta, or gamma subunit of the GABAA channel that abolish block by picrotoxin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1300529

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The role of conserved leucines in the M2 domain of the acetylcholine receptor in channel gating

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1300529

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Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the alpha subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1300529

28 October 2018

The agonist binding site of the gamma-aminobutyric acid type A channel is not formed by the extracellular cysteine loop.

1 reference

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Allosteric receptors after 30 years

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Interaction at End-Plate Receptors between Different Choline Derivatives

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Acetylcholine receptor channel imaged in the open state

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Agonist-induced changes in the structure of the acetylcholine receptor M2 regions revealed by photoincorporation of an uncharged nicotinic noncompetitive antagonist

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12 December 2020

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Identifiers

10.1016/S0006-3495(99)77089-X

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

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