(Q35664020)

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In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation

scientific article published on August 2004

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scholarly article

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Europe PubMed Central

PubMed publication ID

9 August 2017

In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation (English)

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

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Susan Erster

1

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Motohiro Mihara

2

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Roger H Kim

3

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Europe PubMed Central

PubMed publication ID

9 August 2017

Oleksi Petrenko

4

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Europe PubMed Central

PubMed publication ID

9 August 2017

Ute M Moll

5

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Europe PubMed Central

PubMed publication ID

9 August 2017

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publication date

1 August 2004

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Europe PubMed Central

PubMed publication ID

9 August 2017

Molecular and Cellular Biology

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Europe PubMed Central

PubMed publication ID

9 August 2017

24

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Europe PubMed Central

PubMed publication ID

9 August 2017

15

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Europe PubMed Central

PubMed publication ID

9 August 2017

6728-6741

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

1 reference

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12 July 2018

Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

12 July 2018

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

1 reference

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12 July 2018

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

1 reference

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12 July 2018

Integral role of Noxa in p53-mediated apoptotic response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

12 July 2018

p53 has a direct apoptogenic role at the mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

12 July 2018

Tissue-specific induction of p53 targets in vivo.

1 reference

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BID regulation by p53 contributes to chemosensitivity

1 reference

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12 July 2018

A minimal Bcl-x promoter is activated by Brn-3a and repressed by p53

1 reference

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12 July 2018

Mechanisms of p53-dependent apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

12 July 2018

Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

12 July 2018

p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

12 July 2018

Integrity of the N-terminal transcription domain of p53 is required for mutant p53 interference with drug-induced apoptosis

1 reference

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12 July 2018

PUMA, a novel proapoptotic gene, is induced by p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

12 July 2018

PUMA induces the rapid apoptosis of colorectal cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

12 July 2018

p53 activates the mitochondrial death pathway and apoptosis of ventricular myocytes independent of de novo gene transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

12 July 2018

Hypoxia death stimulus induces translocation of p53 protein to mitochondria. Detection by immunofluorescence on whole cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

12 July 2018

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

12 July 2018

p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

12 July 2018

Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

12 July 2018

Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

12 July 2018

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

12 July 2018

PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

12 July 2018

p53 induces apoptosis by caspase activation through mitochondrial cytochrome c release.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

12 July 2018

p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

12 July 2018

A model for p53-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

12 July 2018

Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

12 July 2018

The p53 response to ionising radiation in adult and developing murine tissues.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

12 July 2018

p53 is required for radiation-induced apoptosis in mouse thymocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

12 July 2018

The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

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WAF1, a potential mediator of p53 tumor suppression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

12 July 2018

p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

12 July 2018

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

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Overexpression of the Bcl-2 Protein Increases the Half-life of p21Bax

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

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Bax-deficient mice with lymphoid hyperplasia and male germ cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

12 July 2018

Soluble Fas/APO-1 in tumor cells: a potential regulator of apoptosis?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

12 July 2018

Detection of mitochondrial localization of p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

25 September 2018

The proline-rich domain of p53 is required for cooperation with anti-neoplastic agents to promote apoptosis of tumor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

25 September 2018

The Trp53 pathway is induced in vivo by low doses of gamma radiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

25 September 2018

A transcriptional activation function of p53 is dispensable for and inhibitory of its apoptotic function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

25 September 2018

A transactivation-deficient mouse model provides insights into Trp53 regulation and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

25 September 2018

Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

25 September 2018

Thymocyte apoptosis induced by p53-dependent and independent pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

25 September 2018

Induction of apoptosis in HeLa cells by trans-activation-deficient p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=444865

25 September 2018

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254240

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis in small intestinal epithelial from p53-null mice: evidence for a delayed, p53-independent G2/M-associated cell death after gamma-irradiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254240

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential role for caspase-8 in transcription-independent apoptosis triggered by p53

1 reference

https://pubmed.ncbi.nlm.nih.gov/15254240

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.24.15.6728-6741.2004

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

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