(Q40453583)

English

HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas.

scientific article published on April 2005

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Europe PubMed Central

PubMed publication ID

20 September 2017

HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas. (English)

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

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Stephanie S. Watowich

6

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Gregg L. Semenza

4

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Gregg L Semenza

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

author name string

Michael J Gray

1

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Jing Zhang

2

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Lee M Ellis

3

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Douglas B Evans

5

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Gary E Gallick

7

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Europe PubMed Central

PubMed publication ID

20 September 2017

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publication date

1 April 2005

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Europe PubMed Central

PubMed publication ID

20 September 2017

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Europe PubMed Central

PubMed publication ID

20 September 2017

24

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Europe PubMed Central

PubMed publication ID

20 September 2017

19

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

3110-3120

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis

1 reference

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An essential role for p300/CBP in the cellular response to hypoxia

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Hypoxia-inducible factor-1 and oncogenic signalling

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The role of STATs in transcriptional control and their impact on cellular function

1 reference

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Hypoxia-inducible factor 1 regulates vascular endothelial growth factor expression in human pancreatic cancer

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Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha

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Angiogenesis and metastasis

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Down-regulation of vascular endothelial growth factor in a human colon carcinoma cell line transfected with an antisense expression vector specific for c-src

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Hypoxic Regulation of Lactate Dehydrogenase A

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Regulation of vascular endothelial growth factor expression in human colon carcinoma cells by activity of src kinase

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A high vascular count and overexpression of vascular endothelial growth factor are associated with unfavourable prognosis in operated small cell lung carcinoma.

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Molecular mechanism of hypoxia-inducible factor 1alpha -p300 interaction. A leucine-rich interface regulated by a single cysteine

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Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains. Association with endothelial cell proliferation.

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Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

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Predictive value of vascular endothelial growth factor (VEGF) in metastasis and prognosis of human colorectal cancer

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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Vascular endothelial growth factor (VEGF) expression in prostate cancer and benign prostatic hyperplasia

1 reference

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Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

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Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction

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Activated pp60c-Src leads to elevated hypoxia-inducible factor (HIF)-1alpha expression under normoxia

1 reference

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Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation

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Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

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Vascular endothelial growth factor is a secreted angiogenic mitogen

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Binding and modulation of p53 by p300/CBP coactivators

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7 January 2021

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Prostaglandin E2 induces hypoxia-inducible factor-1alpha stabilization and nuclear localization in a human prostate cancer cell line

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin.

1 reference

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7 January 2021

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Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208513

7 January 2021

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Hypoxia induces vascular endothelial growth factor in cultured human endothelial cells

1 reference

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High expression of vascular endothelial growth factor predicts early recurrence and poor prognosis after curative resection for ductal adenocarcinoma of the pancreas.

1 reference

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Roles of activated Src and Stat3 signaling in melanoma tumor cell growth

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Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

1 reference

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Stat protein transactivation domains recruit p300/CBP through widely divergent sequences

1 reference

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c-Src activates the DNA binding and transcriptional activity of Stat3 molecules: serine 727 is not required for transcriptional activation under certain circumstances

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Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid

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Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

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Increase in activity and level of pp60c-src in progressive stages of human colorectal cancer

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Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells

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Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis

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Nuclear translocation of phosphorylated STAT3 is essential for vascular endothelial growth factor-induced human dermal microvascular endothelial cell migration and tube formation

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Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2, AND p300/CBP.

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Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein

1 reference

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Human p300 protein is a coactivator for the transcription factor MyoD

1 reference

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7 January 2021

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Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling

1 reference

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Ser727-dependent transcriptional activation by association of p300 with STAT3 upon IL-6 stimulation.

1 reference

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Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

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Role of angiogenesis in tumor growth and metastasis

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Stat3 activation by Src induces specific gene regulation and is required for cell transformation

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Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability

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Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha

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Identifiers

10.1038/SJ.ONC.1208513

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

ResearchGate publication ID

0 references

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