(Q418896)

Corticotropin cleavage from POMC

0 references

Opiodes neuropeptide family

1 reference

based on heuristic

inferred from protein domain or family

Pro-opiomelanocortin/corticotropin, ACTH, central region, protein family

1 reference

based on heuristic

inferred from protein domain or family

Pro-opiomelanocortin N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

18 December 2019

1 reference

18 December 2019

type 3 melanocortin receptor binding

1 reference

8 April 2019

Novel binding motif of ACTH analogues at the melanocortin receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

hormone activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

5 references

8 April 2019

ISS

8 April 2019

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

type 1 melanocortin receptor binding

signaling receptor binding

1 reference

8 April 2019

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

G protein-coupled receptor binding

1 reference

24 April 2018

Aberrant trafficking of human melanocortin 1 receptor variants associated with red hair and skin cancer: Steady-state retention of mutant forms in the proximal golgi

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01189&geneProductId=UniProtKB:P01189

type 4 melanocortin receptor binding

1 reference

8 April 2019

Novel binding motif of ACTH analogues at the melanocortin receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

neuropeptide hormone activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01189&geneProductId=UniProtKB:P01189

1 reference

24 April 2018

G protein-coupled receptor binding

1 reference

24 April 2018

Peroxisomal localization of the proopiomelanocortin-derived peptides beta-lipotropin and beta-endorphin

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01189&geneProductId=UniProtKB:P01189

extracellular region

peroxisomal matrix

1 reference

24 April 2018

Peroxisomal localization of the proopiomelanocortin-derived peptides beta-lipotropin and beta-endorphin

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01189&geneProductId=UniProtKB:P01189

secretory granule lumen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

1 reference

8 April 2019

extracellular space

1 reference

24 April 2018

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01189&geneProductId=UniProtKB:P01189

secretory granule

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

extracellular space

extracellular space

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

8 April 2019

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

biological process

glucose homeostasis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

cellular pigmentation

1 reference

8 April 2019

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

cell-cell signaling

1 reference

8 April 2019

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

generation of precursor metabolites and energy

1 reference

8 April 2019

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

regulation of glycogen metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

negative regulation of tumor necrosis factor production

1 reference

8 April 2019

alpha-MSH and its receptors in regulation of tumor necrosis factor-alpha production by human monocyte/macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

regulation of appetite

1 reference

8 April 2019

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

signal transduction

1 reference

8 April 2019

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

positive regulation of transcription by RNA polymerase II

1 reference

8 April 2019

Melanocortin-1 receptor signaling markedly induces the expression of the NR4A nuclear receptor subgroup in melanocytic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

positive regulation of neutrophil mediated killing of fungus

1 reference

24 April 2018

Antimicrobial effects of alpha-MSH peptides

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01189&geneProductId=UniProtKB:P01189

regulation of signaling receptor activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

G protein-coupled receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

1 reference

8 April 2019

cytokine-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

1 reference

8 April 2019

neuropeptide signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01189

1 reference

8 April 2019

Pro-opiomelanocortin/corticotropin, ACTH, central region

Gene Atlas image

PBB GE POMC 205720 at fs.png
732 × 530; 8 KB

0 references

has part(s)

1 reference

Pro-opiomelanocortin N-terminal

1 reference

Opiodes neuropeptide

1 reference