(Q47785594)

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Glutathione-dependent detoxification of alpha-oxoaldehydes by the glyoxalase system: involvement in disease mechanisms and antiproliferative activity of glyoxalase I inhibitors.

scientific article published in April 1998

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9679550%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

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Europe PubMed Central

Glutathione-dependent detoxification of alpha-oxoaldehydes by the glyoxalase system: involvement in disease mechanisms and antiproliferative activity of glyoxalase I inhibitors (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9679550%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

Paul J Thornalley

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9679550%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

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P J Thornalley

1

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Europe PubMed Central

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5 February 2018

http://europepmc.org/abstract/MED/9679550

publication date

1 April 1998

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9679550%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

Chemico-biological Interactions

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9679550%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

111-112

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9679550%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

137-151

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9679550%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

The glyoxalase system in health and disease

1 reference

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alpha-Hydroxyaldehydes, products of lipid peroxidation

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Mechanism of protein modification by glyoxal and glycolaldehyde, reactive intermediates of the Maillard reaction

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The formation of methylglyoxal from triose phosphates. Investigation using a specific assay for methylglyoxal.

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Stabilization of a reaction intermediate as a catalytic device: definition of the functional role of the flexible loop in triosephosphate isomerase.

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The metabolism of aminoacetone to methylglyoxal by semicarbazide-sensitive amine oxidase in human umbilical artery

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gamma,delta-Dioxovalerate as a substrate for the glyoxalase enzyme system

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Negative Association between Erythrocyte Reduced Glutathione Concentration and Diabetic Complications

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Glyoxalase System in Clinical Diabetes Mellitus and Correlation with Diabetic Complications

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Identification of N2-(1-carboxyethyl)guanine (CEG) as a guanine advanced glycosylation end product

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Development of a 32P-postlabelling method for the analysis of 2'-deoxyguanosine-3'-monophosphate and DNA adducts of methylglyoxal

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Modification of the amino group of guanosine by methylglyoxal and other alpha-ketoaldehydes in the presence of hydrogen peroxide

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Advances in glyoxalase research. Glyoxalase expression in malignancy, anti-proliferative effects of methylglyoxal, glyoxalase I inhibitor diesters and S-D-lactoylglutathione, and methylglyoxal-modified protein binding and endocytosis by the advanced

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7 January 2021

Effect of methylglyoxal on human leukaemia 60 cell growth: Modification of DNA, G1 growth arrest and induction of apoptosis

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7 January 2021

Glyoxalase inhibitors as potential anticancer agents

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7 January 2021

Inhibition of proliferation of human leukaemia 60 cells by diethyl esters of glyoxalase inhibitors in vitro

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7 January 2021

Antitumor Activity ofS-(p-Bromobenzyl)glutathione Diestersin Vitro: A Structure−Activity Study

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7 January 2021

Antitumour activity of S-p-bromobenzylglutathione cyclopentyl diester in vitro and in vivo

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7 January 2021

N-acetylcysteine

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7 January 2021

Modification of the glyoxalase system in human red blood cells by glucose in vitro

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7 January 2021

Modification of the glyoxalase system in streptozotocin-induced diabetic rats

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7 January 2021

Glucose may induce cell death through a free radical-mediated mechanism

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7 January 2021

The reaction of methylglyoxal with aminoguanidine under physiological conditions and prevention of methylglyoxal binding to plasma proteins.

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7 January 2021

Protein cross-linking by the Maillard reaction. Isolation, characterization, and in vivo detection of a lysine-lysine cross-link derived from methylglyoxal

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7 January 2021

N-epsilon-(carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteins

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7 January 2021

The assay of methylglyoxal in biological systems byderivatization with 1,2-diamino-4,5-dimethoxybenzene

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7 January 2021

Methylglyoxal-modified arginine residues — a signal for receptor-mediated endocytosis and degradation of proteins by monocytic THP-1 cells

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7 January 2021

Induction of synthesis and secretion of interleukin 1β in the human monocytic THP-1 cells by human serum albumins modified with methylglyoxal and advanced glycation endproducts

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7 January 2021

Macrophage scavenger receptor mediates the endocytic uptake and degradation of advanced glycation end products of the Maillard reaction

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Synthesis and secretion of macrophage colony stimulating factor by mature human monocytes and human monocytic THP-1 cells induced by human serum albumin derivatives modified with methylglyoxal and glucose-derived advanced glycation endproducts

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7 January 2021

Maillard reaction products and their relation to complications in insulin-dependent diabetes mellitus

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7 January 2021

Role of glycation in modification of lens crystallins in diabetic and nondiabetic senile cataracts

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Exogenous advanced glycosylation end products induce complex vascular dysfunction in normal animals: a model for diabetic and aging complications

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Advanced glycation end products contribute to amyloidosis in Alzheimer disease

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beta 2-Microglobulin modified with advanced glycation end products is a major component of hemodialysis-associated amyloidosis

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Free radical generation during delta-aminolevulinic acid autoxidation: induction by hemoglobin and connections with porphyrinpathies

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Identifiers

10.1016/S0009-2797(97)00157-9

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9679550%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9679550%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

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