To evaluate the effects from the fresh flowers of Pithecellobium dulce (Roxb.) Benth, belonging t... more To evaluate the effects from the fresh flowers of Pithecellobium dulce (Roxb.) Benth, belonging to the family of Leguminosae subfamily Mimosoideae, a glycoside quercitin has been isolated. The ethyl acetate soluble of P. dulce containing the above glycoside was studied both in silico and in vitro for the anti-inflammatory and anti-bacterial properties. The concatenation of the in silico and in vivo has been done. Results indicated the activity of this flavonol glycoside in the protection of HRBC lysis and against the gram positive micro organisms, thus confirming its anti-inflammatory and anti-bacterial properties.
ABSTRACT The essential oil extracted by hydro-distillation from rhizome of Curcuma caesia Roxb. g... more ABSTRACT The essential oil extracted by hydro-distillation from rhizome of Curcuma caesia Roxb. grown in southern India were analyzed by gas chromatography and gas chromatography–mass spectrometry. A total of 35 volatile essential oil components were identified in the extracted oil of C. caesia representing tropolone (15.86 %) as major compound, ledol (3.27 %), β-elemenone (3.03 %) and α-bulnesene (3.02 %), spathulenol (2.42 %) as minor compounds and borneol (0.85 %), α-terpineol (0.77 %), eucalyptol (0.62 %), caryophyllene (0.45 %) as trace compounds. The results from our analysis indicated that levels of sesquiterpene (62.8 %) were more than those of monoterpene components (1.4 %).
Reviews in Advanced Sciences and Engineering, 2014
ABSTRACT Bioinspiration through biological nanomachines and their assemblies at molecular level p... more ABSTRACT Bioinspiration through biological nanomachines and their assemblies at molecular level provide guiding principles to build nanoscale functional devices. The rapid advances in the biosynthesis of nanomaterials, including hybrid nanomaterials and their applications are reviewed. Biological synthesis of nanostructures using whole organism as well as biomolecules as reducing agents is addressed. Self-assembly of nanomaterials and their role in drug delivery is also emphasized.
The ability to calculate the correct sequence alignment is crucial to many types of studies. The ... more The ability to calculate the correct sequence alignment is crucial to many types of studies. The accuracy in alignment is critical in predicting gene ancestry, the number and location of point mutations, evolutionary distance and phylogeny. A study was conducted to test the biological significance of PIR pairwise alignment using 40 N-terminal signal peptides of different taxonomic origin and having various functions. Our results suggest that PIR pairwise alignment is not ideal for some proteins with N-terminal signal peptides, because it produces an erroneous alignment that lacks both statistical and biological significances. This communication discusses the shortcomings in the PIR pairwise alignment tool and calls for a cautious approach while using it for signal peptides.
Cheminformatics approaches are currently not employed in any of the spices to study the medicinal... more Cheminformatics approaches are currently not employed in any of the spices to study the medicinal properties traditionally attributed to them. The aim of this study is to find the most efficacious molecule which do not have toxic effects but at the same time have desired pharmacokinetic profile. In the present study of the class 'diphenylheptanoids' from turmeric, cheminformatics methods were employed to predict properties such as physicochemical properties, Absorption, Distribution, Metabolism, Toxicity (mutagenicity, rodent carcinogenicity and human hepatotoxicity). These studies confirmed that curcumin and its derivatives cause dose-dependent hepatotoxicity. The results of these studies indicate that, in contrast to curcumin, few other compounds in turmeric such as compounds (8) and (9) [refer text], exhibit better activities and are drugable and do not have any side-effects.
International Journal of Green Nanotechnology, 2012
Extensive work has been done to explore the potential promises of plant systems in the synthesis ... more Extensive work has been done to explore the potential promises of plant systems in the synthesis of metal nanoparticles. We report here a green approach for the synthesis of silver nanoparticles with a cocktail of biochemical constituents from cashew apple juice (Anacardium occidentale L.). We presume that the reduction potential of these constituents in the crude extract plays a vital
International Journal of Green Nanotechnology, 2012
Extensive work has been done to explore the potential promises of plant systems in the synthesis ... more Extensive work has been done to explore the potential promises of plant systems in the synthesis of metal nanoparticles. Herein, a convenient and rapid process for the formation of silver nanoparticles with natural reducing and capping agents of Daucus carrota (L.) is reported. The synchronization of secondary metabolites and enzymes as reducing/capping agents plays a vital role in the synthesis
To evaluate the effects from the fresh flowers of Pithecellobium dulce (Roxb.) Benth, belonging t... more To evaluate the effects from the fresh flowers of Pithecellobium dulce (Roxb.) Benth, belonging to the family of Leguminosae subfamily Mimosoideae, a glycoside quercitin has been isolated. The ethyl acetate soluble of P. dulce containing the above glycoside was studied both in silico and in vitro for the anti-inflammatory and anti-bacterial properties. The concatenation of the in silico and in vivo has been done. Results indicated the activity of this flavonol glycoside in the protection of HRBC lysis and against the gram positive micro organisms, thus confirming its anti-inflammatory and anti-bacterial properties.
ABSTRACT The essential oil extracted by hydro-distillation from rhizome of Curcuma caesia Roxb. g... more ABSTRACT The essential oil extracted by hydro-distillation from rhizome of Curcuma caesia Roxb. grown in southern India were analyzed by gas chromatography and gas chromatography–mass spectrometry. A total of 35 volatile essential oil components were identified in the extracted oil of C. caesia representing tropolone (15.86 %) as major compound, ledol (3.27 %), β-elemenone (3.03 %) and α-bulnesene (3.02 %), spathulenol (2.42 %) as minor compounds and borneol (0.85 %), α-terpineol (0.77 %), eucalyptol (0.62 %), caryophyllene (0.45 %) as trace compounds. The results from our analysis indicated that levels of sesquiterpene (62.8 %) were more than those of monoterpene components (1.4 %).
Reviews in Advanced Sciences and Engineering, 2014
ABSTRACT Bioinspiration through biological nanomachines and their assemblies at molecular level p... more ABSTRACT Bioinspiration through biological nanomachines and their assemblies at molecular level provide guiding principles to build nanoscale functional devices. The rapid advances in the biosynthesis of nanomaterials, including hybrid nanomaterials and their applications are reviewed. Biological synthesis of nanostructures using whole organism as well as biomolecules as reducing agents is addressed. Self-assembly of nanomaterials and their role in drug delivery is also emphasized.
The ability to calculate the correct sequence alignment is crucial to many types of studies. The ... more The ability to calculate the correct sequence alignment is crucial to many types of studies. The accuracy in alignment is critical in predicting gene ancestry, the number and location of point mutations, evolutionary distance and phylogeny. A study was conducted to test the biological significance of PIR pairwise alignment using 40 N-terminal signal peptides of different taxonomic origin and having various functions. Our results suggest that PIR pairwise alignment is not ideal for some proteins with N-terminal signal peptides, because it produces an erroneous alignment that lacks both statistical and biological significances. This communication discusses the shortcomings in the PIR pairwise alignment tool and calls for a cautious approach while using it for signal peptides.
Cheminformatics approaches are currently not employed in any of the spices to study the medicinal... more Cheminformatics approaches are currently not employed in any of the spices to study the medicinal properties traditionally attributed to them. The aim of this study is to find the most efficacious molecule which do not have toxic effects but at the same time have desired pharmacokinetic profile. In the present study of the class 'diphenylheptanoids' from turmeric, cheminformatics methods were employed to predict properties such as physicochemical properties, Absorption, Distribution, Metabolism, Toxicity (mutagenicity, rodent carcinogenicity and human hepatotoxicity). These studies confirmed that curcumin and its derivatives cause dose-dependent hepatotoxicity. The results of these studies indicate that, in contrast to curcumin, few other compounds in turmeric such as compounds (8) and (9) [refer text], exhibit better activities and are drugable and do not have any side-effects.
International Journal of Green Nanotechnology, 2012
Extensive work has been done to explore the potential promises of plant systems in the synthesis ... more Extensive work has been done to explore the potential promises of plant systems in the synthesis of metal nanoparticles. We report here a green approach for the synthesis of silver nanoparticles with a cocktail of biochemical constituents from cashew apple juice (Anacardium occidentale L.). We presume that the reduction potential of these constituents in the crude extract plays a vital
International Journal of Green Nanotechnology, 2012
Extensive work has been done to explore the potential promises of plant systems in the synthesis ... more Extensive work has been done to explore the potential promises of plant systems in the synthesis of metal nanoparticles. Herein, a convenient and rapid process for the formation of silver nanoparticles with natural reducing and capping agents of Daucus carrota (L.) is reported. The synchronization of secondary metabolites and enzymes as reducing/capping agents plays a vital role in the synthesis
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