Complex queries are becoming commonplace, with the growing use of decision support systems. Decis... more Complex queries are becoming commonplace, with the growing use of decision support systems. Decision support queries often have a lot of common sub-expressions within each query, and queries are often run as a batch. Multi query optimization aims at exploiting common sub-expressions, to reduce the evaluation cost of queries, by computing them once and then caching them for future use, both within individual queries and across queries in a batch. In case cache space is limited, the total size of sub-expressions that are worth caching may exceed available cache space. Prior work in multi query optimization involves choosing a set of common sub-expressions that fit in available cache space, and once computed, retaining their results across the execution of all queries in a batch. Such optimization algorithms do not consider the possibility of dynamically changing the cache contents. This may lead to sub-expressions occupying cache space even if they are not used by subsequent queries. The available cache space can be best utilized by evaluating the queries in an appropriate order and changing the cache contents as queries are executed. We present several algorithms that consider these factors, in order to reduce the cost of query evaluation
Gulati S, Kher V, Sharma RK, Gupta A. Steroid response pattern in Indian children with nephrotic ... more Gulati S, Kher V, Sharma RK, Gupta A. Steroid response pattern in Indian children with nephrotic syndrome. Acta Pædiatr 1994;83:530–3. Stockholm. ISSN 08033–5253The steroid response pattern to standard prednisolone therapy is of immense diagnostic, therapeutic and prognostic value for the treating physician in managing children with nephrotic syndrome. None of the studies from our country has analysed the clinical, biochemical and histopathological profile in different steroid response categories. To address this problem we conducted a study comprising 127 children with nephrotic syndrome referred to our Institute. They were treated with oral prednisolone according to the APN protocol. Based on the subsequent response these children were classified into different steroid response categories on follow-up. Of the 116 children with follow-up of more than six months, infrequent relapsers constituted the majority (37.9%). The frequency of other steroid response categories was as follows: frequent relapsers (21.6%), steroid-dependent (18.1%), initial non-responders (17.3%) and subsequent non-responders (5.1%). The factors predicting a poor response to standard prednisolone therapy in our study were age of onset more than eight years, male sex, hypertension, microscopic haematuria and presence of non-minimal change nephrotic syndrome lesions on histopathology
The treatment of steroid-resistant minimal change nephrotic syndrome (MCNS) continues to pose a t... more The treatment of steroid-resistant minimal change nephrotic syndrome (MCNS) continues to pose a therapeutic challenge. We conducted a randomised prospective controlled trial to evaluate the efficacy of IV cyclophosphamide compared with oral cyclophosphamide in 13 children with biopsy-proven steroid-resistant MCNS. All 7 patients receiving IV cyclophosphamide achieved remission; this was sustained in 4 patients, while 3 relapsed. However, even these 3 patients subsequently became steroid sensitive. Of the 6 patients who received oral cyclophosphamide, 2 dropped out, 1 responded and 3 children continued to remain steroid resistant. The children who received IV cyclophosphamide had more sustained remissions, longer periods without proteinuria and fewer significant side effects; this was achieved at a lower cumulative dose.
Complex queries are becoming commonplace, with the growing use of decision support systems. Decis... more Complex queries are becoming commonplace, with the growing use of decision support systems. Decision support queries often have a lot of common sub-expressions within each query, and queries are often run as a batch. Multi query optimization aims at exploiting common sub-expressions, to reduce the evaluation cost of queries, by computing them once and then caching them for future use, both within individual queries and across queries in a batch. In case cache space is limited, the total size of sub-expressions that are worth caching may exceed available cache space. Prior work in multi query optimization involves choosing a set of common sub-expressions that fit in available cache space, and once computed, retaining their results across the execution of all queries in a batch. Such optimization algorithms do not consider the possibility of dynamically changing the cache contents. This may lead to sub-expressions occupying cache space even if they are not used by subsequent queries. The available cache space can be best utilized by evaluating the queries in an appropriate order and changing the cache contents as queries are executed. We present several algorithms that consider these factors, in order to reduce the cost of query evaluation
Gulati S, Kher V, Sharma RK, Gupta A. Steroid response pattern in Indian children with nephrotic ... more Gulati S, Kher V, Sharma RK, Gupta A. Steroid response pattern in Indian children with nephrotic syndrome. Acta Pædiatr 1994;83:530–3. Stockholm. ISSN 08033–5253The steroid response pattern to standard prednisolone therapy is of immense diagnostic, therapeutic and prognostic value for the treating physician in managing children with nephrotic syndrome. None of the studies from our country has analysed the clinical, biochemical and histopathological profile in different steroid response categories. To address this problem we conducted a study comprising 127 children with nephrotic syndrome referred to our Institute. They were treated with oral prednisolone according to the APN protocol. Based on the subsequent response these children were classified into different steroid response categories on follow-up. Of the 116 children with follow-up of more than six months, infrequent relapsers constituted the majority (37.9%). The frequency of other steroid response categories was as follows: frequent relapsers (21.6%), steroid-dependent (18.1%), initial non-responders (17.3%) and subsequent non-responders (5.1%). The factors predicting a poor response to standard prednisolone therapy in our study were age of onset more than eight years, male sex, hypertension, microscopic haematuria and presence of non-minimal change nephrotic syndrome lesions on histopathology
The treatment of steroid-resistant minimal change nephrotic syndrome (MCNS) continues to pose a t... more The treatment of steroid-resistant minimal change nephrotic syndrome (MCNS) continues to pose a therapeutic challenge. We conducted a randomised prospective controlled trial to evaluate the efficacy of IV cyclophosphamide compared with oral cyclophosphamide in 13 children with biopsy-proven steroid-resistant MCNS. All 7 patients receiving IV cyclophosphamide achieved remission; this was sustained in 4 patients, while 3 relapsed. However, even these 3 patients subsequently became steroid sensitive. Of the 6 patients who received oral cyclophosphamide, 2 dropped out, 1 responded and 3 children continued to remain steroid resistant. The children who received IV cyclophosphamide had more sustained remissions, longer periods without proteinuria and fewer significant side effects; this was achieved at a lower cumulative dose.
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Papers by Amit Gupta