Cilj ovog osvrta je skrenuti pozornost na dijagnosticke nedoumice i neusklađenost dijagnostickih ... more Cilj ovog osvrta je skrenuti pozornost na dijagnosticke nedoumice i neusklađenost dijagnostickih kriterija za secernu bolest u ranoj trudnoci ko
ObjectiveLittle information exists related to the contribution of assisted reproductive technolog... more ObjectiveLittle information exists related to the contribution of assisted reproductive technology (ART) twins to the preterm and very preterm birth rate. We sought to examine this contribution over a period of more than two decades in a tertiary perinatal center.MethodsWe identified all preterm births from 1993 to 2017, born at <37 or <32 weeks’ gestation, by mode of conception [in vitro fertilization (IVF) vs. non-IVF pregnancies]. We generated trend lines of the annual change of the dependent variable (% preterm birth).ResultsWe evaluated 74,299 births, including 3934 (5.3%) preterm births at <37 and 826 (1.1%) at <32 weeks’ gestation. In this period, 1019 (1.4%) twin pairs were born including 475 (46.6%) and 80 (7.8%) at <37 and <32 weeks, respectively. There were 213 (5.4%) IVF pregnancies among the preterm births at <37 weeks, including 88 (41.3%) twins. Fifteen (1.8%) births of all IVF gestations were at <32 weeks, and all were twins. Whereas the annua...
Objective To assess the effect of fetal gender in small-for-gestational age (SGA) neonates with b... more Objective To assess the effect of fetal gender in small-for-gestational age (SGA) neonates with birth weight less than the fifth percentile by gestational age. Methods We compared male and female SGA neonates for maternal and neonatal outcomes in the following gestational age subgroups: at <32 + 6, 33 + 0–36 + 6 and at ≥37 + 0 weeks of gestation. Results We examined 159, 154 and 2363 SGA neonates born at <32 + 6, 33 + 0 to 36 + 6 and ≥37 weeks of pregnancy, respectively, whose birth weight was below the fifth percentile for gestational age and who met our inclusion criteria. Overall, there were no significant differences between the mothers of males and females, except that there were more males at term and the incidence of nulliparas was greater among the mothers of males. In terms of outcomes, males had a similar incidence of respiratory distress syndrome (RDS), intraventricular hemorrhage (IVH) and admissions to intensive care. Interestingly, low Apgar scores were more comm...
Gynaecologia et perinatologia : journal for gynaecology, perinatology, reproductive medicine and ultrasonic diagnostics, 2010
SA`ETAK. U radu je opisan rijedak slu~aj neprepoznate fetalne smrti u 39. tjednu trudno}e u mlade... more SA`ETAK. U radu je opisan rijedak slu~aj neprepoznate fetalne smrti u 39. tjednu trudno}e u mlade rodilje sa sinusnom tahikardijom. Tijekom detaljne analize ovog opstetri~kog slu~aja identificirane su subjektivne pogre{ke stru~nog osoblja koje je zanemarilo neke postupke opstetri~ke propedeutike, ali su opa`ene i neke objektivne okolnosti koje su ote`ale dijagnozu kasne fetalne smrti, prije svega postojanje sinusne tahikardije, kojoj je trudnica bila sklona. Nesretnu okolnost autori su na{li i u ~injenici da je »CTG krivulja« sa snimljenom sr~anom akcijom majke tijekom prijema u ra|aonicu bila vrlo sli~na uobi~ajenoj krivulji s registriranim fetalnim sr~anim otkucajima, pa je do{lo do tragi~ne zamjene. Autori apeliraju na stalan opstetri~arov oprez, kriti~ko klini~ko promi{ljanje i potrebu za preispitivanjem pojedinih stru~nih odluka, osobito ako su tijekom analize prepoznate neke klini~ke sumnje i nelogi~nosti.
Vise od polovice žena fertilne dobi najrazvijenijih zemalja Zapada ima prekomjernu tjelesnu težin... more Vise od polovice žena fertilne dobi najrazvijenijih zemalja Zapada ima prekomjernu tjelesnu težinu. Debljina smanjuje mogucnost trudnoce. Masno j
Problem: The influence of decidual dendritic cells (DC) on decidual NK cells was investigated. Ma... more Problem: The influence of decidual dendritic cells (DC) on decidual NK cells was investigated. Material and methods: Distribution of CD83+ cells in early pregnancy decidua was analysed in comparison with trophoblast invasion and NK cell-infiltration using immunohistology. Phenotype, origin, maturation state and cytokine expression of DC were detected by flow cytometry. Magnetically purified CD56+ and CD83+ cells were co-cultured. Proliferation CFSE assay, CD69 and cytolytic mediators expression in NK cells were analysed. Results: CD83+DC were found in the vicinity of NK cells at the area of trophoblast invasion and expressed CD86, HLA-DR and CD11c in vitro. DC expressed also IL-15, IL-18 and IFNgamma. CD83+DC increased proliferation, CD69 and cytolytic mediator expression in decidual NK cells. Conclusion: Mature decidual DC of mostly myeloid origin are capable to activate decidual NK cells in vitro. The investigation was supported by Croatian Ministry of Science, Grant No. 0062029 and European FVI Project (EMBIC, LSHM-CT-2004-512040, NoE).
To determine the proportion of newborns diagnosed with hearing impairment through the hearing imp... more To determine the proportion of newborns diagnosed with hearing impairment through the hearing impairment screening program in newborns, and the frequency of 35delG/GJB2 mutation as a cause of hearing impairment. The results of the study imply the integration of the mutation analysis in the neonatal screening program. Evoked otoacustic emission (E-OAE) screening program was performed among 6019 newborns at the Department of Obstetrics and Gynaecology, Rijeka University Hospital Center, between October 2002 and December 2004. Newborns diagnosed with hearing impairment were re-examined after three weeks and if abnormal responses persisted, the diagnosis was evaluated by auditory brainstem evoked response (ABER) testing. Children with confirmed diagnosis were examined by allele-specific polymerase chain reaction to identify the presence of 35delG/GJB2 mutation. After the first and second stage of screening, 86 newborns were suspect of having hearing impairment. ABER confirmed the diagno...
Acta medica Croatica : c̆asopis Hravatske akademije medicinskih znanosti, 1998
Treatment with omeprazole (OME), azithromycin (AZI) and amoxicillin (AMO) resulted in encouraging... more Treatment with omeprazole (OME), azithromycin (AZI) and amoxicillin (AMO) resulted in encouraging Helicobacter pylori cure rates in pilot and control studies. The aim of this study was to establish whether OME + AZI in combination with either AMO or ACA (amoxicillin plus clavulanic acid) are effective in curing H. pylori infection. A hundred patients with active duodenal ulcer and H. pylori infection were treated with OME (day 1-10: 2 x 40 mg/day, day 11-24: 40 mg/day, day 25-42: 20 mg/day) plus AZI 500 mg/day for the first 6 days. Patients were randomly assigned to either AMO 2 x 1000 mg/day (group A, n = 50) or ACA 2 x 1250 mg/day (group B, n = 50) during the first 10 days of treatment. H. pylori status was determined by urease test and histology before and 6 weeks after completion of therapy. Ninety-five patients completed the study. H. pylori infection was eradicated in 85.4% (41/48) patients from group A (intention-to-treat (ITT) analysis: 82%) versus 91.5% (43/47) patients fro...
Cilj ovog osvrta je skrenuti pozornost na dijagnosticke nedoumice i neusklađenost dijagnostickih ... more Cilj ovog osvrta je skrenuti pozornost na dijagnosticke nedoumice i neusklađenost dijagnostickih kriterija za secernu bolest u ranoj trudnoci ko
ObjectiveLittle information exists related to the contribution of assisted reproductive technolog... more ObjectiveLittle information exists related to the contribution of assisted reproductive technology (ART) twins to the preterm and very preterm birth rate. We sought to examine this contribution over a period of more than two decades in a tertiary perinatal center.MethodsWe identified all preterm births from 1993 to 2017, born at <37 or <32 weeks’ gestation, by mode of conception [in vitro fertilization (IVF) vs. non-IVF pregnancies]. We generated trend lines of the annual change of the dependent variable (% preterm birth).ResultsWe evaluated 74,299 births, including 3934 (5.3%) preterm births at <37 and 826 (1.1%) at <32 weeks’ gestation. In this period, 1019 (1.4%) twin pairs were born including 475 (46.6%) and 80 (7.8%) at <37 and <32 weeks, respectively. There were 213 (5.4%) IVF pregnancies among the preterm births at <37 weeks, including 88 (41.3%) twins. Fifteen (1.8%) births of all IVF gestations were at <32 weeks, and all were twins. Whereas the annua...
Objective To assess the effect of fetal gender in small-for-gestational age (SGA) neonates with b... more Objective To assess the effect of fetal gender in small-for-gestational age (SGA) neonates with birth weight less than the fifth percentile by gestational age. Methods We compared male and female SGA neonates for maternal and neonatal outcomes in the following gestational age subgroups: at <32 + 6, 33 + 0–36 + 6 and at ≥37 + 0 weeks of gestation. Results We examined 159, 154 and 2363 SGA neonates born at <32 + 6, 33 + 0 to 36 + 6 and ≥37 weeks of pregnancy, respectively, whose birth weight was below the fifth percentile for gestational age and who met our inclusion criteria. Overall, there were no significant differences between the mothers of males and females, except that there were more males at term and the incidence of nulliparas was greater among the mothers of males. In terms of outcomes, males had a similar incidence of respiratory distress syndrome (RDS), intraventricular hemorrhage (IVH) and admissions to intensive care. Interestingly, low Apgar scores were more comm...
Gynaecologia et perinatologia : journal for gynaecology, perinatology, reproductive medicine and ultrasonic diagnostics, 2010
SA`ETAK. U radu je opisan rijedak slu~aj neprepoznate fetalne smrti u 39. tjednu trudno}e u mlade... more SA`ETAK. U radu je opisan rijedak slu~aj neprepoznate fetalne smrti u 39. tjednu trudno}e u mlade rodilje sa sinusnom tahikardijom. Tijekom detaljne analize ovog opstetri~kog slu~aja identificirane su subjektivne pogre{ke stru~nog osoblja koje je zanemarilo neke postupke opstetri~ke propedeutike, ali su opa`ene i neke objektivne okolnosti koje su ote`ale dijagnozu kasne fetalne smrti, prije svega postojanje sinusne tahikardije, kojoj je trudnica bila sklona. Nesretnu okolnost autori su na{li i u ~injenici da je »CTG krivulja« sa snimljenom sr~anom akcijom majke tijekom prijema u ra|aonicu bila vrlo sli~na uobi~ajenoj krivulji s registriranim fetalnim sr~anim otkucajima, pa je do{lo do tragi~ne zamjene. Autori apeliraju na stalan opstetri~arov oprez, kriti~ko klini~ko promi{ljanje i potrebu za preispitivanjem pojedinih stru~nih odluka, osobito ako su tijekom analize prepoznate neke klini~ke sumnje i nelogi~nosti.
Vise od polovice žena fertilne dobi najrazvijenijih zemalja Zapada ima prekomjernu tjelesnu težin... more Vise od polovice žena fertilne dobi najrazvijenijih zemalja Zapada ima prekomjernu tjelesnu težinu. Debljina smanjuje mogucnost trudnoce. Masno j
Problem: The influence of decidual dendritic cells (DC) on decidual NK cells was investigated. Ma... more Problem: The influence of decidual dendritic cells (DC) on decidual NK cells was investigated. Material and methods: Distribution of CD83+ cells in early pregnancy decidua was analysed in comparison with trophoblast invasion and NK cell-infiltration using immunohistology. Phenotype, origin, maturation state and cytokine expression of DC were detected by flow cytometry. Magnetically purified CD56+ and CD83+ cells were co-cultured. Proliferation CFSE assay, CD69 and cytolytic mediators expression in NK cells were analysed. Results: CD83+DC were found in the vicinity of NK cells at the area of trophoblast invasion and expressed CD86, HLA-DR and CD11c in vitro. DC expressed also IL-15, IL-18 and IFNgamma. CD83+DC increased proliferation, CD69 and cytolytic mediator expression in decidual NK cells. Conclusion: Mature decidual DC of mostly myeloid origin are capable to activate decidual NK cells in vitro. The investigation was supported by Croatian Ministry of Science, Grant No. 0062029 and European FVI Project (EMBIC, LSHM-CT-2004-512040, NoE).
To determine the proportion of newborns diagnosed with hearing impairment through the hearing imp... more To determine the proportion of newborns diagnosed with hearing impairment through the hearing impairment screening program in newborns, and the frequency of 35delG/GJB2 mutation as a cause of hearing impairment. The results of the study imply the integration of the mutation analysis in the neonatal screening program. Evoked otoacustic emission (E-OAE) screening program was performed among 6019 newborns at the Department of Obstetrics and Gynaecology, Rijeka University Hospital Center, between October 2002 and December 2004. Newborns diagnosed with hearing impairment were re-examined after three weeks and if abnormal responses persisted, the diagnosis was evaluated by auditory brainstem evoked response (ABER) testing. Children with confirmed diagnosis were examined by allele-specific polymerase chain reaction to identify the presence of 35delG/GJB2 mutation. After the first and second stage of screening, 86 newborns were suspect of having hearing impairment. ABER confirmed the diagno...
Acta medica Croatica : c̆asopis Hravatske akademije medicinskih znanosti, 1998
Treatment with omeprazole (OME), azithromycin (AZI) and amoxicillin (AMO) resulted in encouraging... more Treatment with omeprazole (OME), azithromycin (AZI) and amoxicillin (AMO) resulted in encouraging Helicobacter pylori cure rates in pilot and control studies. The aim of this study was to establish whether OME + AZI in combination with either AMO or ACA (amoxicillin plus clavulanic acid) are effective in curing H. pylori infection. A hundred patients with active duodenal ulcer and H. pylori infection were treated with OME (day 1-10: 2 x 40 mg/day, day 11-24: 40 mg/day, day 25-42: 20 mg/day) plus AZI 500 mg/day for the first 6 days. Patients were randomly assigned to either AMO 2 x 1000 mg/day (group A, n = 50) or ACA 2 x 1250 mg/day (group B, n = 50) during the first 10 days of treatment. H. pylori status was determined by urease test and histology before and 6 weeks after completion of therapy. Ninety-five patients completed the study. H. pylori infection was eradicated in 85.4% (41/48) patients from group A (intention-to-treat (ITT) analysis: 82%) versus 91.5% (43/47) patients fro...
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