Sample size is a critical parameter for clinical studies. However, to many biomedical and psychos... more Sample size is a critical parameter for clinical studies. However, to many biomedical and psychosocial investigators, power and sample size analysis seems like a magic trick of statisticians. In this paper, we continue to discuss power and sample size calculations by focusing on binary outcomes. We again emphasize the importance of close interactions between investigators and biostatisticians in setting up hypotheses and carrying out power analyses.
Sample size justification is required for all clinical studies. However, to many biomedical and c... more Sample size justification is required for all clinical studies. However, to many biomedical and clinical researchers, power and sample size analysis seems like a magic trick of statisticians. In this note, we discuss power and sample size calculations and show that biomedical and clinical investigators play a significant role in making such analyses possible and meaningful. Thus, power analysis is really an interactive process and scientific researchers and statisticians are equal partners in the research enterprise.
BackgroundUterine serous carcinoma (USC) is an aggressive subtype of endometrial carcinoma which ... more BackgroundUterine serous carcinoma (USC) is an aggressive subtype of endometrial carcinoma which has been increasing at alarming rates, particularly among Asian, Hispanic and Black women. USC has not been well characterized in terms of mutational status, pattern of metastases and survival.ObjectiveTo investigate the association between sites of recurrence and metastases of USC, mutational status, race, and overall survival (OS).MethodsThis single-center retrospective study evaluated patients with biopsy-proven USC that underwent genomic testing between January 2015 and July 2021. Association between genomic profile and sites of metastases or recurrence was performed using χ2 or Fisher’s exact test. Survival curves for ethnicity and race, mutations, sites of metastasis/recurrence were estimated using the Kaplan-Meier method and compared with log-rank test. Cox proportional hazard regression models were used to examine the association between OS with age, race, ethnicity, mutational s...
Sample size is a critical parameter for clinical studies. However, to many biomedical and psychos... more Sample size is a critical parameter for clinical studies. However, to many biomedical and psychosocial investigators, power and sample size analysis seems like a magic trick of statisticians. In this paper, we continue to discuss power and sample size calculations by focusing on binary outcomes. We again emphasize the importance of close interactions between investigators and biostatisticians in setting up hypotheses and carrying out power analyses.
Sample size justification is required for all clinical studies. However, to many biomedical and c... more Sample size justification is required for all clinical studies. However, to many biomedical and clinical researchers, power and sample size analysis seems like a magic trick of statisticians. In this note, we discuss power and sample size calculations and show that biomedical and clinical investigators play a significant role in making such analyses possible and meaningful. Thus, power analysis is really an interactive process and scientific researchers and statisticians are equal partners in the research enterprise.
BackgroundUterine serous carcinoma (USC) is an aggressive subtype of endometrial carcinoma which ... more BackgroundUterine serous carcinoma (USC) is an aggressive subtype of endometrial carcinoma which has been increasing at alarming rates, particularly among Asian, Hispanic and Black women. USC has not been well characterized in terms of mutational status, pattern of metastases and survival.ObjectiveTo investigate the association between sites of recurrence and metastases of USC, mutational status, race, and overall survival (OS).MethodsThis single-center retrospective study evaluated patients with biopsy-proven USC that underwent genomic testing between January 2015 and July 2021. Association between genomic profile and sites of metastases or recurrence was performed using χ2 or Fisher’s exact test. Survival curves for ethnicity and race, mutations, sites of metastasis/recurrence were estimated using the Kaplan-Meier method and compared with log-rank test. Cox proportional hazard regression models were used to examine the association between OS with age, race, ethnicity, mutational s...
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Papers by Jiangnan Lyu