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Papers by Jan Hendrikx Netherlands Journal of Medicine , 1997
... Ie 1.4.2 1.5 1.5.1 1.5.2 1.5.2.a 1.5.2.b 1.5.2.e 1.5.2.d 1.5.3 1.6 1.6.1 1.6.2 1.6.3 1.7 ... ... more ... Ie 1.4.2 1.5 1.5.1 1.5.2 1.5.2.a 1.5.2.b 1.5.2.e 1.5.2.d 1.5.3 1.6 1.6.1 1.6.2 1.6.3 1.7 ... Not yet classified adhesion molecules CIA PSGL-l ESL-l Lu-ECAM-l 10 Lymphocytes homing to cutaneous endothelial cells Lymphocytes, myeloid cells MyeloId cells Lung epithelial cells Ligands ...
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Self-renewal and differentiation of hematopoietic stem and progenitor cells are defined by the en... more Self-renewal and differentiation of hematopoietic stem and progenitor cells are defined by the ensembles of genes expressed by these cells. Here we report identification of a novel gene named Jedi, which is expressed predominantly in short- and long-term repopulating stem cells when compared to more mature bone marrow progenitors. Jedi mRNA encodes a transmembrane protein that contains multiple EGF-like repeats. Jedi and two earlier reported proteins, MEGF10 and MEGF11, share a substantial homology and are likely to represent a novel protein family. Studies of the potential role of Jedi in hematopoietic regulation demonstrated that the retrovirally mediated expression of Jedi in bone marrow cells decreased the number of myeloid progenitors in in vitro clonogenic assays. In addition, expression of Jedi in NIH 3T3 fibroblasts resulted in a decreased number of late and early myeloid progenitors in the non-adherent co-cultured bone marrow cells. Jedi shares a number of structural features with the Jagged/Serrate/Delta family of Notch ligands, and our experiments indicate that the extracellular domain of Jedi, similar to the corresponding domain of Jagged1, inhibits Notch signaling. On the basis of obtained results, we suggest that Jedi is involved in the fine regulation of the early stages of hematopoietic differentiation, presumably through the Notch signaling pathway. J. Cell. Biochem. 101: 767–784, 2007. © 2007 Wiley-Liss, Inc.
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Iubmb Life , 1997
Non-receptor tyrosine kinase Chk has been implicated in hematopoietic development. To study the f... more Non-receptor tyrosine kinase Chk has been implicated in hematopoietic development. To study the function of Chk in vivo, we have generated chk-deficient mice using gene targeting. Overall development of mice homozygous for this mutation was apparently normal. Blood counts, FACS analysis of hematopoietic cell populations, CFU-C and CAFC assays showed no significant difference between wild type and mutant animals. Thus, the dispensability of Chk for mouse development and hematopoiesis suggests that its function may be redundant in vivo, and most likely be compensated by activity of a closely related protein tyrosine kinase Csk.
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Brazilian Journal of Medical and Biological Research , 2005
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Nature Medicine , 2002
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Netherlands Journal of Medicine , 1997
... Ie 1.4.2 1.5 1.5.1 1.5.2 1.5.2.a 1.5.2.b 1.5.2.e 1.5.2.d 1.5.3 1.6 1.6.1 1.6.2 1.6.3 1.7 ... ... more ... Ie 1.4.2 1.5 1.5.1 1.5.2 1.5.2.a 1.5.2.b 1.5.2.e 1.5.2.d 1.5.3 1.6 1.6.1 1.6.2 1.6.3 1.7 ... Not yet classified adhesion molecules CIA PSGL-l ESL-l Lu-ECAM-l 10 Lymphocytes homing to cutaneous endothelial cells Lymphocytes, myeloid cells MyeloId cells Lung epithelial cells Ligands ...
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Virology , 1995
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Journal of Cellular Biochemistry , 2007
Self-renewal and differentiation of hematopoietic stem and progenitor cells are defined by the en... more Self-renewal and differentiation of hematopoietic stem and progenitor cells are defined by the ensembles of genes expressed by these cells. Here we report identification of a novel gene named Jedi, which is expressed predominantly in short- and long-term repopulating stem cells when compared to more mature bone marrow progenitors. Jedi mRNA encodes a transmembrane protein that contains multiple EGF-like repeats. Jedi and two earlier reported proteins, MEGF10 and MEGF11, share a substantial homology and are likely to represent a novel protein family. Studies of the potential role of Jedi in hematopoietic regulation demonstrated that the retrovirally mediated expression of Jedi in bone marrow cells decreased the number of myeloid progenitors in in vitro clonogenic assays. In addition, expression of Jedi in NIH 3T3 fibroblasts resulted in a decreased number of late and early myeloid progenitors in the non-adherent co-cultured bone marrow cells. Jedi shares a number of structural features with the Jagged/Serrate/Delta family of Notch ligands, and our experiments indicate that the extracellular domain of Jedi, similar to the corresponding domain of Jagged1, inhibits Notch signaling. On the basis of obtained results, we suggest that Jedi is involved in the fine regulation of the early stages of hematopoietic differentiation, presumably through the Notch signaling pathway. J. Cell. Biochem. 101: 767–784, 2007. © 2007 Wiley-Liss, Inc.
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Iubmb Life , 1997
Non-receptor tyrosine kinase Chk has been implicated in hematopoietic development. To study the f... more Non-receptor tyrosine kinase Chk has been implicated in hematopoietic development. To study the function of Chk in vivo, we have generated chk-deficient mice using gene targeting. Overall development of mice homozygous for this mutation was apparently normal. Blood counts, FACS analysis of hematopoietic cell populations, CFU-C and CAFC assays showed no significant difference between wild type and mutant animals. Thus, the dispensability of Chk for mouse development and hematopoiesis suggests that its function may be redundant in vivo, and most likely be compensated by activity of a closely related protein tyrosine kinase Csk.
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Brazilian Journal of Medical and Biological Research , 2005
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Nature Medicine , 2002
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Papers by Jan Hendrikx