Serbian Journal of Dermatology and Venereology, 2016
Sarcoidosis is an enigmatic, multisystem granulomatous disease of unknown etiology and wide range... more Sarcoidosis is an enigmatic, multisystem granulomatous disease of unknown etiology and wide range of clinical presentations. Case report: A 54-year-old female presented with facial rash: polymorphic, round, infiltrated erythematous plaques, 1 - 3 cm in size, disseminated on several areas of the face. The medical history was consistent with dermatitis herpetiformis and persistent intrahepatic cholestasis. The laboratory test results suggested celiac disease (strong positivity of IgA anti-tissue transglutaminase antibodies) but upper endoscopy was not performed to confirm it. The skin biopsy revealed noncaseating epithelioid-cell granulomas, and negative direct immunofluorescence showed IgA deposits in the dermis. Sarcoidosis with cutaneous and hepatic involvement was established based on compatible clinical findings and supportive histology. The period between manifestations of Duhring disease and skin manifestations of sarcoidosis was 20 years. Conclusion: Our clinical case supports...
Research in atherosclerosis for a long time has been focused mostly upon the intimal changes. The... more Research in atherosclerosis for a long time has been focused mostly upon the intimal changes. The outer layer, the adventitia has been entirely neglected. Very recently, results confirming adventitial remodeling appeared. However, data concerning atherosclerotic involvement of arterial adventitial layer are few. The purpose of the present study is to look for adventitial remodeling in a sample of postmortem human coronary arteries. Irregular thickening, collagen overproduction, and hypercellularity, as well as mononuclear infiltration and abundance of newly-formed blood vessels were the most common findings in the adventitia of human coronary arteries. These results are similar to those found experimentally and strongly suggest that adventitia and adventitial remodeling are not innocent bystanders in atherogenesis.
Serbian Journal of Dermatology and Venereology, 2016
Sarcoidosis is an enigmatic, multisystem granulomatous disease of unknown etiology and wide range... more Sarcoidosis is an enigmatic, multisystem granulomatous disease of unknown etiology and wide range of clinical presentations. Case report: A 54-year-old female presented with facial rash: polymorphic, round, infiltrated erythematous plaques, 1 - 3 cm in size, disseminated on several areas of the face. The medical history was consistent with dermatitis herpetiformis and persistent intrahepatic cholestasis. The laboratory test results suggested celiac disease (strong positivity of IgA anti-tissue transglutaminase antibodies) but upper endoscopy was not performed to confirm it. The skin biopsy revealed noncaseating epithelioid-cell granulomas, and negative direct immunofluorescence showed IgA deposits in the dermis. Sarcoidosis with cutaneous and hepatic involvement was established based on compatible clinical findings and supportive histology. The period between manifestations of Duhring disease and skin manifestations of sarcoidosis was 20 years. Conclusion: Our clinical case supports...
Research in atherosclerosis for a long time has been focused mostly upon the intimal changes. The... more Research in atherosclerosis for a long time has been focused mostly upon the intimal changes. The outer layer, the adventitia has been entirely neglected. Very recently, results confirming adventitial remodeling appeared. However, data concerning atherosclerotic involvement of arterial adventitial layer are few. The purpose of the present study is to look for adventitial remodeling in a sample of postmortem human coronary arteries. Irregular thickening, collagen overproduction, and hypercellularity, as well as mononuclear infiltration and abundance of newly-formed blood vessels were the most common findings in the adventitia of human coronary arteries. These results are similar to those found experimentally and strongly suggest that adventitia and adventitial remodeling are not innocent bystanders in atherogenesis.
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