Le Centre pour la Communication Scientifique Directe - HAL - Diderot, 2013
A simple, sensitive, selective rapid spectrophotometric method has been developed for the determi... more A simple, sensitive, selective rapid spectrophotometric method has been developed for the determination of post synaptic I±1- Adrino receptor antagonist Methotrexate in pure form and pharmaceutical formulations based on the oxidative coupling reaction with 2, 2- Bipyridine reagent, at PH_4.0 which is extractable at 510 nm. Beerâs law is obeyed in the concentration ranges 4-24 I¼g ml-1. The developed method was applied directly and easily for the analysis of the Pharmaceutical formulations. R.S.D was found to be 0.2859% and Recovery 98.99% respectively. The method was completely validated and proven to be rugged. The interferences of the other ingredients and excipients were not observed. The repeatability and the performance of the proved method were established by point and internal hypothesis and through recovery studies.
A simple RP-HPLC method developed for simultaneous estimation of Olmesartan medoxomil and Hydroch... more A simple RP-HPLC method developed for simultaneous estimation of Olmesartan medoxomil and Hydrochlorothiazide in combined pharmaceutical dosage forms. This method validated as per ICH guidelines. This method was simple, specific, precise, linear, accurate, robust and ruggedness for simultaneous analysis of both Olmesartan medoxomil and Hydrochlorothiazide.
Le Centre pour la Communication Scientifique Directe - HAL - Diderot, 2013
A simple, sensitive, selective rapid spectrophotometric method has been developed for the determi... more A simple, sensitive, selective rapid spectrophotometric method has been developed for the determination of post synaptic I±1- Adrino receptor antagonist Methotrexate in pure form and pharmaceutical formulations based on the oxidative coupling reaction with 2, 2- Bipyridine reagent, at PH_4.0 which is extractable at 510 nm. Beerâs law is obeyed in the concentration ranges 4-24 I¼g ml-1. The developed method was applied directly and easily for the analysis of the Pharmaceutical formulations. R.S.D was found to be 0.2859% and Recovery 98.99% respectively. The method was completely validated and proven to be rugged. The interferences of the other ingredients and excipients were not observed. The repeatability and the performance of the proved method were established by point and internal hypothesis and through recovery studies.
A simple RP-HPLC method developed for simultaneous estimation of Olmesartan medoxomil and Hydroch... more A simple RP-HPLC method developed for simultaneous estimation of Olmesartan medoxomil and Hydrochlorothiazide in combined pharmaceutical dosage forms. This method validated as per ICH guidelines. This method was simple, specific, precise, linear, accurate, robust and ruggedness for simultaneous analysis of both Olmesartan medoxomil and Hydrochlorothiazide.
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