Background: Ischemic stroke poses a major threat to human beings, and a prompt intravenous thromb... more Background: Ischemic stroke poses a major threat to human beings, and a prompt intravenous thrombolytic management remains the gold standard protocol for stroke sufferers. Although the role of thrombolytic therapy (r-tPA) for ischemic stroke patients and those with underlying impaired renal function has been advocated as effective treating strategy, there is still a lack of investigation as to finding out baseline important variables that are capable of early outcome prediction. Objectives: In this project, we hypothesize that the change of clinical chronic kidney disease (CKD) staging (delta stage = CKD stage after 3-month follow-up – CKD stage at admission) could serve as a crucial predictor of the prognosis of patients. Design: This is a cohort longitudinal retrospective study. Sources and Methods: A total of 765 cerebral artery ischemic stroke patients with impaired renal function were recruited and followed up for 1 year. Among them, 116 had received the thrombolytic treatment ...
Background and purpose The implantation of carotid artery stents prevents recurrent ischemic stro... more Background and purpose The implantation of carotid artery stents prevents recurrent ischemic stroke in patients with carotid stenosis. This study aimed to investigate associations between change of ophthalmic artery flow (COAF) post carotid stenting and recurrent ischemic stroke, as well as the link toward the anterior and posterior circulations and patients’ prognosis after carotid stenting. Methods This retrospective, longitudinal cohort study recruited 87 left side carotid stenosed ischemic stroke patients undergoing left side carotid stenting between year of 2009 and 2013, and patients were followed up to 9 years after carotid procedures. Clinical data were derived from medical records. The primary outcome was stroke recurrence. Predictive factors were stenosis > 50% in one intracranial artery and ROAF. Kaplan–Meier and Cox regression analyses were used to identify risk factors associated with stroke recurrence. Results Among 87 included patients undergone left side carotid ...
E LSR method.<b>Copyright information:</b>Taken from "Using the longest signific... more E LSR method.<b>Copyright information:</b>Taken from "Using the longest significance run to estimate region-specific p-values in genetic association mapping studies"http://www.biomedcentral.com/1471-2105/9/246BMC Bioinformatics 2008;9():246-246.Published online 27 May 2008PMCID:PMC2430975.
To estimate the incidence and clinical characteristics of rhegmatogenous retinal detachment (RRD)... more To estimate the incidence and clinical characteristics of rhegmatogenous retinal detachment (RRD) in Taiwan. This was a nationwide, population-based retrospective study of patients with RRD. Data from the Taiwan National Health Insurance Research Database (2000-2012), which represents 4% of the total population in Taiwan, were analysed. The incidence of RRD and its associations with age, gender and high myopia were analysed. A total of 2359 patients with RRD (1336 men and 1023 women) were identified from 2000-2012. The age-standardised incidence rate of RRD over the 13-year period was 16.40±1.06 per 10(5) person-years (18.89 and 13.93 for men and women, respectively, p<0.0001) and an average age of 47.76±0.67 years. The incidence in both genders had an obvious peak at 50-69 years of age, and a secondary peak at 20-29 years in women. Concomitant high myopia was noted in 10.51% of the patients, with an average of 39.72±1.95 years. Prior cataract extraction was noted in 11.06% of th...
Women with menopausal symptoms show evidence of accelerated epigenetic ageing, vascular aging and... more Women with menopausal symptoms show evidence of accelerated epigenetic ageing, vascular aging and low‐grade systemic inflammation status. However, data are limited regarding menopausal symptoms and risk of heart failure (HF). We aimed to explore the impact of menopausal symptoms on risk of HF.
Journal of the Formosan Medical Association = Taiwan yi zhi, Jan 7, 2018
Chromium and nickel are important soil pollutants in Taiwan. Previously, we showed that blood chr... more Chromium and nickel are important soil pollutants in Taiwan. Previously, we showed that blood chromium levels correlated strongly with soil chromium levels. Our observation that many patients with dry eyes or a dry mouth came from areas where soils contain high chromium levels prompted us to investigate whether incidence and prevalence of SS are higher in areas where soils contain high levels of heavy metals. We used a database from national health insurance (NHI) to study the epidemiology of SS. It was ascertained by at least 3 hospital visits with the diagnosis within 12 months. We then compared the results with the information about heavy metal contents in farm soils. The incidence of SS was significantly increased (3.6 fold) in the areas where soils contained high levels of chromium and nickel. In contrast, lead, copper, or arsenic did not show such a strong association. Both the prevalence and incidence of SS are significantly increased in areas where soils contain high levels ...
Air pollution, weather condition and influenza are known risk factors of acute coronary syndrome ... more Air pollution, weather condition and influenza are known risk factors of acute coronary syndrome (ACS) among elderly people. The influenza vaccine (IV) has been shown to reduce major cardiovascular events. The purpose of this study was to compare resistance to air pollution and weather factors causing ACS between vaccinated and less-vaccinated elderly people. A case-crossover design was applied to 1835 elderly ACS patients who were obtained from the 1-million sample of Taiwan National Health Insurance Research Data with inclusion criteria: (1) the first diagnosis of ACS was in cold season and at age 68 or more, (2) had received the free IV program at least once during the period 3years before the ACS. They were stratified into two groups: 707 had received flu vaccinations for all the 3years and the remaining 1128 had not. The measurements of air pollutants, temperature, and humidity corresponding to each of the 3days prior to the ACS diagnosis date were retrieved from the data banks...
Differential diagnosis for neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis ... more Differential diagnosis for neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) is always doubtful. To differentiate these diseases, we studied the immune status in the blood of patients with MS (n = 45) or NMOSD (n = 23) at remission phase. Remitting NMOSD patients had increased levels of CXCL13 and memory B cells, while remitting MS patients had elevated levels of galectin-9 and Th1 cells. A diagnostic model with these four variables is built to distinguish remitting NMOSD from MS with a sensitivity of 91.30%. Our diagnostic model may help to improve the differentiation of remitting NMOSD from MS.
Background: Ischemic stroke poses a major threat to human beings, and a prompt intravenous thromb... more Background: Ischemic stroke poses a major threat to human beings, and a prompt intravenous thrombolytic management remains the gold standard protocol for stroke sufferers. Although the role of thrombolytic therapy (r-tPA) for ischemic stroke patients and those with underlying impaired renal function has been advocated as effective treating strategy, there is still a lack of investigation as to finding out baseline important variables that are capable of early outcome prediction. Objectives: In this project, we hypothesize that the change of clinical chronic kidney disease (CKD) staging (delta stage = CKD stage after 3-month follow-up – CKD stage at admission) could serve as a crucial predictor of the prognosis of patients. Design: This is a cohort longitudinal retrospective study. Sources and Methods: A total of 765 cerebral artery ischemic stroke patients with impaired renal function were recruited and followed up for 1 year. Among them, 116 had received the thrombolytic treatment ...
Background and purpose The implantation of carotid artery stents prevents recurrent ischemic stro... more Background and purpose The implantation of carotid artery stents prevents recurrent ischemic stroke in patients with carotid stenosis. This study aimed to investigate associations between change of ophthalmic artery flow (COAF) post carotid stenting and recurrent ischemic stroke, as well as the link toward the anterior and posterior circulations and patients’ prognosis after carotid stenting. Methods This retrospective, longitudinal cohort study recruited 87 left side carotid stenosed ischemic stroke patients undergoing left side carotid stenting between year of 2009 and 2013, and patients were followed up to 9 years after carotid procedures. Clinical data were derived from medical records. The primary outcome was stroke recurrence. Predictive factors were stenosis > 50% in one intracranial artery and ROAF. Kaplan–Meier and Cox regression analyses were used to identify risk factors associated with stroke recurrence. Results Among 87 included patients undergone left side carotid ...
E LSR method.<b>Copyright information:</b>Taken from "Using the longest signific... more E LSR method.<b>Copyright information:</b>Taken from "Using the longest significance run to estimate region-specific p-values in genetic association mapping studies"http://www.biomedcentral.com/1471-2105/9/246BMC Bioinformatics 2008;9():246-246.Published online 27 May 2008PMCID:PMC2430975.
To estimate the incidence and clinical characteristics of rhegmatogenous retinal detachment (RRD)... more To estimate the incidence and clinical characteristics of rhegmatogenous retinal detachment (RRD) in Taiwan. This was a nationwide, population-based retrospective study of patients with RRD. Data from the Taiwan National Health Insurance Research Database (2000-2012), which represents 4% of the total population in Taiwan, were analysed. The incidence of RRD and its associations with age, gender and high myopia were analysed. A total of 2359 patients with RRD (1336 men and 1023 women) were identified from 2000-2012. The age-standardised incidence rate of RRD over the 13-year period was 16.40±1.06 per 10(5) person-years (18.89 and 13.93 for men and women, respectively, p<0.0001) and an average age of 47.76±0.67 years. The incidence in both genders had an obvious peak at 50-69 years of age, and a secondary peak at 20-29 years in women. Concomitant high myopia was noted in 10.51% of the patients, with an average of 39.72±1.95 years. Prior cataract extraction was noted in 11.06% of th...
Women with menopausal symptoms show evidence of accelerated epigenetic ageing, vascular aging and... more Women with menopausal symptoms show evidence of accelerated epigenetic ageing, vascular aging and low‐grade systemic inflammation status. However, data are limited regarding menopausal symptoms and risk of heart failure (HF). We aimed to explore the impact of menopausal symptoms on risk of HF.
Journal of the Formosan Medical Association = Taiwan yi zhi, Jan 7, 2018
Chromium and nickel are important soil pollutants in Taiwan. Previously, we showed that blood chr... more Chromium and nickel are important soil pollutants in Taiwan. Previously, we showed that blood chromium levels correlated strongly with soil chromium levels. Our observation that many patients with dry eyes or a dry mouth came from areas where soils contain high chromium levels prompted us to investigate whether incidence and prevalence of SS are higher in areas where soils contain high levels of heavy metals. We used a database from national health insurance (NHI) to study the epidemiology of SS. It was ascertained by at least 3 hospital visits with the diagnosis within 12 months. We then compared the results with the information about heavy metal contents in farm soils. The incidence of SS was significantly increased (3.6 fold) in the areas where soils contained high levels of chromium and nickel. In contrast, lead, copper, or arsenic did not show such a strong association. Both the prevalence and incidence of SS are significantly increased in areas where soils contain high levels ...
Air pollution, weather condition and influenza are known risk factors of acute coronary syndrome ... more Air pollution, weather condition and influenza are known risk factors of acute coronary syndrome (ACS) among elderly people. The influenza vaccine (IV) has been shown to reduce major cardiovascular events. The purpose of this study was to compare resistance to air pollution and weather factors causing ACS between vaccinated and less-vaccinated elderly people. A case-crossover design was applied to 1835 elderly ACS patients who were obtained from the 1-million sample of Taiwan National Health Insurance Research Data with inclusion criteria: (1) the first diagnosis of ACS was in cold season and at age 68 or more, (2) had received the free IV program at least once during the period 3years before the ACS. They were stratified into two groups: 707 had received flu vaccinations for all the 3years and the remaining 1128 had not. The measurements of air pollutants, temperature, and humidity corresponding to each of the 3days prior to the ACS diagnosis date were retrieved from the data banks...
Differential diagnosis for neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis ... more Differential diagnosis for neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) is always doubtful. To differentiate these diseases, we studied the immune status in the blood of patients with MS (n = 45) or NMOSD (n = 23) at remission phase. Remitting NMOSD patients had increased levels of CXCL13 and memory B cells, while remitting MS patients had elevated levels of galectin-9 and Th1 cells. A diagnostic model with these four variables is built to distinguish remitting NMOSD from MS with a sensitivity of 91.30%. Our diagnostic model may help to improve the differentiation of remitting NMOSD from MS.
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