There is great interest in metal nanoparticle (MNP)-based local drug-delivery systems (DDSs), but... more There is great interest in metal nanoparticle (MNP)-based local drug-delivery systems (DDSs), but most methods employ drug agents with additional MNPs, and it is challenging to design composite nanosystems involving dissimilar molecular building blocks. In this chapter, we have reviewed the advance of anticancer organometallic agents on the basis of iron complexes. In particular, we have highlighted chemotherapeutically active inorganic iron-complex-based advanced local magneto-DDS composites via self-assembly of iron complexes, without the use of common magnetites and anticancer prodrugs. Distinguishing features of the molecular nanocomposites will be discussed on simultaneous performance of multiple tasks in guided DDS, MRI, and magneto-hyperthermal effect, which will be suitable for a wide variety of “minimally invasive” theranostic clinics, including targeted DDS.
L'invention concerne un medicament, qui comprend un compose organique ou inorganique et est m... more L'invention concerne un medicament, qui comprend un compose organique ou inorganique et est magnetise par modification des chaines laterales et/ou de la reticulation entre les chaines laterales.
Designing multi-modal topical drug delivery nanocarriers using nano-hybrid particles has received... more Designing multi-modal topical drug delivery nanocarriers using nano-hybrid particles has received significant interest in targeted cancer therapy. In this study, magnetic Fe(salen)-conducting copolymer nanocomposites based on our previous iron salt-free synthesis method are surface-functionalized with methotrexate and transferrin proteins. The nano-hybrids show near-infrared-/magnetic field-responsive hyperthermal activity in vitro, which can be extraordinarily useful in magnetically guidable local cancer targeting as a versatile multi-modal therapeutic drug delivery system.
A risk-based maintenance (RBM) technique has been generated to optimize inspection and maintenanc... more A risk-based maintenance (RBM) technique has been generated to optimize inspection and maintenance plans for fossil-fired power plants which will be deregulated in Japan. In the present study, technological advances and problems are considered that have resulted from the application of the RBM to actual boiler plants with operating times exceeding 100,000 hours. Risk is defined as the product of the likelihood of damage in plant components by the consequence due to failure of the components or system. The present study found that the RBM is a useful decision tool for determining inspection priority, mitigation of undesirable risk, extension of the inspection period, and other improvements in maintenance practice. At the same time, serious potential problems are brought out.
We previously reported that μ-oxo N,N'-bis(salicylidene)ethylenediamine iron [Fe(Salen)], a m... more We previously reported that μ-oxo N,N'-bis(salicylidene)ethylenediamine iron [Fe(Salen)], a magnetic organic compound, has direct anti-tumor activity, and generates heat in an alternating magnetic field (AMF). We showed that Fe(Salen) nanoparticles are useful for combined hyperthermia-chemotherapy of tongue cancer. Here, we have examined the effect of Fe(Salen) on human glioblastoma (GB). Fe(Salen) showed in vitro anti-tumor activity towards several human GB cell lines. It inhibited cell proliferation, and its apoptosis-inducing activity was greater than that of clinically used drugs. Fe(Salen) also showed in vivo anti-tumor activity in the mouse brain. We evaluated the drug distribution and systemic side effects of intracerebrally injected Fe(Salen) nanoparticles in rats. Further, to examine whether hyperthermia, which was induced by exposing Fe(Salen) nanoparticles to AMF, enhanced the intrinsic anti-tumor effect of Fe(Salen), we used a mouse model grafted with U251 cells on t...
We previously reported the efficacy of anti-cancer therapy with hyperthermia using an alternating... more We previously reported the efficacy of anti-cancer therapy with hyperthermia using an alternating magnetic field (AMF) and a magnetic compound. In the course of the study, unexpectedly, we found that an AMF enhances the cytotoxicity of Compound C, an activated protein kinase (AMPK) inhibitor, although this compound is not magnetic. We thus examined the cellular mechanism of AMF-induced cytotoxicity of Compound C in cultured human glioblastoma (GB) cells. An AMF (280 kHz, 250 Arms) for 30 minutes significantly enhanced the cytotoxicity of Compound C and promoted apoptosis towards several human GB cell lines in vitro. The AMF also increased Compound C-induced cell-cycle arrest of GB cells at the G2 phase and thus inhibited cell proliferation. The AMF increased Compound C-induced reactive oxygen species (ROS) production. Furthermore, the AMF decreased ERK phosphorylation in the presence of Compound C and suppressed the protective autophagy induced by this compound. The application of a...
Iron-salen, i.e., μ-oxo-N,N'-bis(salicylidene)ethylenediamine iron (Fe(Salen)) was a recently... more Iron-salen, i.e., μ-oxo-N,N'-bis(salicylidene)ethylenediamine iron (Fe(Salen)) was a recently identified as a new anti-cancer compound with intrinsic magnetic properties. Chelation therapy has been widely used in management of metallic poisoning, because an administration of agents that bind metals can prevent potential lethal effects of particular metal. In this study, we confirmed the therapeutic effect of deferoxamine mesylate (DFO) chelation against Fe(Salen) as part of the chelator antidote efficacy. DFO administration resulted in reduced cytotoxicity and ROS generation by Fe(Salen) in cancer cells. DFO (25 mg/kg) reduced the onset of Fe(Salen) (25 mg/kg)-induced acute liver and renal dysfunction. DFO (300 mg/kg) improves survival rate after systematic injection of a fatal dose of Fe(Salen) (200 mg/kg) in mice. DFO enables the use of higher Fe(Salen) doses to treat progressive states of cancer, and it also appears to decrease the acute side effects of Fe(Salen). This makes ...
Crystals that have silicon clusters as lattice points can be expected to be new artificial materi... more Crystals that have silicon clusters as lattice points can be expected to be new artificial materials as a superconductor and a new type of photoemission elements. Although there has been little information on electronic structures on silicon micro clusters. We report for the first time their electronic structures and the structural differences between fully relaxed structures and symmetry conserving structures
There is great interest in metal nanoparticle (MNP)-based local drug-delivery systems (DDSs), but... more There is great interest in metal nanoparticle (MNP)-based local drug-delivery systems (DDSs), but most methods employ drug agents with additional MNPs, and it is challenging to design composite nanosystems involving dissimilar molecular building blocks. In this chapter, we have reviewed the advance of anticancer organometallic agents on the basis of iron complexes. In particular, we have highlighted chemotherapeutically active inorganic iron-complex-based advanced local magneto-DDS composites via self-assembly of iron complexes, without the use of common magnetites and anticancer prodrugs. Distinguishing features of the molecular nanocomposites will be discussed on simultaneous performance of multiple tasks in guided DDS, MRI, and magneto-hyperthermal effect, which will be suitable for a wide variety of “minimally invasive” theranostic clinics, including targeted DDS.
L'invention concerne un medicament, qui comprend un compose organique ou inorganique et est m... more L'invention concerne un medicament, qui comprend un compose organique ou inorganique et est magnetise par modification des chaines laterales et/ou de la reticulation entre les chaines laterales.
Designing multi-modal topical drug delivery nanocarriers using nano-hybrid particles has received... more Designing multi-modal topical drug delivery nanocarriers using nano-hybrid particles has received significant interest in targeted cancer therapy. In this study, magnetic Fe(salen)-conducting copolymer nanocomposites based on our previous iron salt-free synthesis method are surface-functionalized with methotrexate and transferrin proteins. The nano-hybrids show near-infrared-/magnetic field-responsive hyperthermal activity in vitro, which can be extraordinarily useful in magnetically guidable local cancer targeting as a versatile multi-modal therapeutic drug delivery system.
A risk-based maintenance (RBM) technique has been generated to optimize inspection and maintenanc... more A risk-based maintenance (RBM) technique has been generated to optimize inspection and maintenance plans for fossil-fired power plants which will be deregulated in Japan. In the present study, technological advances and problems are considered that have resulted from the application of the RBM to actual boiler plants with operating times exceeding 100,000 hours. Risk is defined as the product of the likelihood of damage in plant components by the consequence due to failure of the components or system. The present study found that the RBM is a useful decision tool for determining inspection priority, mitigation of undesirable risk, extension of the inspection period, and other improvements in maintenance practice. At the same time, serious potential problems are brought out.
We previously reported that μ-oxo N,N'-bis(salicylidene)ethylenediamine iron [Fe(Salen)], a m... more We previously reported that μ-oxo N,N'-bis(salicylidene)ethylenediamine iron [Fe(Salen)], a magnetic organic compound, has direct anti-tumor activity, and generates heat in an alternating magnetic field (AMF). We showed that Fe(Salen) nanoparticles are useful for combined hyperthermia-chemotherapy of tongue cancer. Here, we have examined the effect of Fe(Salen) on human glioblastoma (GB). Fe(Salen) showed in vitro anti-tumor activity towards several human GB cell lines. It inhibited cell proliferation, and its apoptosis-inducing activity was greater than that of clinically used drugs. Fe(Salen) also showed in vivo anti-tumor activity in the mouse brain. We evaluated the drug distribution and systemic side effects of intracerebrally injected Fe(Salen) nanoparticles in rats. Further, to examine whether hyperthermia, which was induced by exposing Fe(Salen) nanoparticles to AMF, enhanced the intrinsic anti-tumor effect of Fe(Salen), we used a mouse model grafted with U251 cells on t...
We previously reported the efficacy of anti-cancer therapy with hyperthermia using an alternating... more We previously reported the efficacy of anti-cancer therapy with hyperthermia using an alternating magnetic field (AMF) and a magnetic compound. In the course of the study, unexpectedly, we found that an AMF enhances the cytotoxicity of Compound C, an activated protein kinase (AMPK) inhibitor, although this compound is not magnetic. We thus examined the cellular mechanism of AMF-induced cytotoxicity of Compound C in cultured human glioblastoma (GB) cells. An AMF (280 kHz, 250 Arms) for 30 minutes significantly enhanced the cytotoxicity of Compound C and promoted apoptosis towards several human GB cell lines in vitro. The AMF also increased Compound C-induced cell-cycle arrest of GB cells at the G2 phase and thus inhibited cell proliferation. The AMF increased Compound C-induced reactive oxygen species (ROS) production. Furthermore, the AMF decreased ERK phosphorylation in the presence of Compound C and suppressed the protective autophagy induced by this compound. The application of a...
Iron-salen, i.e., μ-oxo-N,N'-bis(salicylidene)ethylenediamine iron (Fe(Salen)) was a recently... more Iron-salen, i.e., μ-oxo-N,N'-bis(salicylidene)ethylenediamine iron (Fe(Salen)) was a recently identified as a new anti-cancer compound with intrinsic magnetic properties. Chelation therapy has been widely used in management of metallic poisoning, because an administration of agents that bind metals can prevent potential lethal effects of particular metal. In this study, we confirmed the therapeutic effect of deferoxamine mesylate (DFO) chelation against Fe(Salen) as part of the chelator antidote efficacy. DFO administration resulted in reduced cytotoxicity and ROS generation by Fe(Salen) in cancer cells. DFO (25 mg/kg) reduced the onset of Fe(Salen) (25 mg/kg)-induced acute liver and renal dysfunction. DFO (300 mg/kg) improves survival rate after systematic injection of a fatal dose of Fe(Salen) (200 mg/kg) in mice. DFO enables the use of higher Fe(Salen) doses to treat progressive states of cancer, and it also appears to decrease the acute side effects of Fe(Salen). This makes ...
Crystals that have silicon clusters as lattice points can be expected to be new artificial materi... more Crystals that have silicon clusters as lattice points can be expected to be new artificial materials as a superconductor and a new type of photoemission elements. Although there has been little information on electronic structures on silicon micro clusters. We report for the first time their electronic structures and the structural differences between fully relaxed structures and symmetry conserving structures
A risk-based maintenance (RBM) technique has been generated to optimize inspection and maintenanc... more A risk-based maintenance (RBM) technique has been generated to optimize inspection and maintenance plans for fossil-fired power plants which will be deregulated in Japan. In the present study, technological advances and problems are considered that have resulted from the application of the RBM to actual boiler plants with operating times exceeding 100,000 hours. Risk is defined as the product of the likelihood of damage in plant components by the consequence due to failure of the components or system. The present study found that the RBM is a useful decision tool for determining inspection priority, mitigation of undesirable risk, extension of the inspection period, and other improvements in maintenance practice. At the same time, serious potential problems are brought out.
Uploads