BMC complementary medicine and therapies, May 22, 2024
Background Several studies showed the hypoglycemic and hypolipidemic effects of Satureja Khuzesta... more Background Several studies showed the hypoglycemic and hypolipidemic effects of Satureja Khuzestanica (SK) in animal models. This study aimed to determine the effect of SK supplementation on glycemic and lipid outcomes of patients with type 2 diabetes mellitus (T2DM). Methods The study was designed as a double-blind, placebo-controlled, randomized clinical trial using block randomization. Seventy-eight T2DM patients were randomly assigned to intervention (n = 39) or placebo (n = 39) groups. They received SK or placebo in 500 mg capsules daily for 12 weeks. Anthropometric, blood pressure, liver enzymes, glycemic, and lipid outcomes were measured before and after the intervention. Results At baseline, there were no significant differences in age, sex, or glycated hemoglobin (HbA1c) levels between the groups. SK supplementation led to a significant decrease in FBS (-12.6 ± 20.7 mg/dl in the intervention group versus 3.5 ± 31.9 mg/dl; p = 0.007), HbA1c (-0.28 ± 0.45 in the intervention group versus 0.11 ± 0.54% in the placebo group; p = < 0.001), insulin (-1.65 ± 6.18 in the intervention group versus 2.09 ± 5.90 mIU/L in the placebo group; p = 0.03), total cholesterol (-14.6 ± 21.1 mg/dl in the intervention group versus 8.2 ± 30.9 mg/dl in the placebo group; p < 0.001), LDL-cholesterol (-4.6 ± 15.2 mg/dl in the intervention group versus 5.8 ± 14.6 mg/dl in placebo group; p < 0.001) levels, and significant increase in HDL-cholesterol (3.9 ± 4.9 mg/dl in the intervention group versus 0.9 ± 5.2 mg/dl in placebo group; p = 0.005). Conclusion Based on the study results, SK supplementation may improve glycemic indices and lipid profile of patients with T2DM. Our findings may provide novel complementary treatments without adverse effects for diabetes complications. These results need to be further confirmed in clinical trials. Registration : This trial has been registered in the Iranian Registry of Clinical Trials (IRCT ID: IRCT20190715044214N1, registration date: 21/02/2021).
3 fatty acids and vitamin E supplementation can affect gene expressions of SIRT1, FOXO1 and UCP-2... more 3 fatty acids and vitamin E supplementation can affect gene expressions of SIRT1, FOXO1 and UCP-2 in Coronary artery disease patients, Obesity Medicine,
Journal of Food Science and Nutrition, Sep 30, 2020
Dietary modification is an effective method for preventing and managing hypertension. Therefore, ... more Dietary modification is an effective method for preventing and managing hypertension. Therefore, we conducted a systematic review and meta-analysis to assess the effects of different dietary approaches for comparing high- and low-carbohydrate diets on systolic and diastolic blood pressure (SBP and DBP, respectively) in patients with type 2 diabetes mellitus (T2DM). We carried out a comprehensive literature search using PubMed, the Cochrane Library, Web of Science, and Scopus without any language and time restrictions until April, 2019. We carried out a meta-analysis using both fixed and random effects models where appropriate and used the I2 index to evaluate heterogeneity. We identified 16 eligible studies, with a total of 1,610 participants. The overall pooled net effect of different dietary approaches on SBP and DBP were −2.29 mmHg [95% confidence interval (CI): −3.49 to −1.1] and −1.03 mmHg (95% CI: −1.77 to −0.29), respectively, compared with high-carbohydrate diets. Indeed, diets high in monounsaturated fatty acids more effective in reducing both SBP and DBP than high-carbohydrate diets, whereas high-protein diets were not effective. Furthermore, we found that different dietary approaches, such as low-fat diets, did not reduce SBP or DBP to a greater extent than low-carbohydrate diets. Overall, the results of our meta-analysis show that diets high in monounsaturated fatty acids are more effective in reducing both SBP and DBP than diets high in carbohydrate, whereas other dietary approaches were not effective.
Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment, 2010
In the present study ninety nine polished white rice samples were collected in three areas, all o... more In the present study ninety nine polished white rice samples were collected in three areas, all over Lorestan Province located in the west of Iran, and analysed for six elements by Flame Atomic Absorption Spectrometry (FAAS). For individual elements, Zinc (Zn) showed the highest concentration among the analysed essential elements with a mean of 28.6 mg kg(-1) and next to copper (Cu) of 22.8 mg kg(-1). Analysis of the essential and toxic elements for possible inter-area variation by ANOVA showed that there are significant differences between the areas. There was no significant difference between areas for Zn concentrations. Most of the samples nearly contained world wide average concentration of iron (Fe) and Zn in rice grains that were reported by various researches. But, the content of calcium (Ca) in the rice samples produced in Lorestan Province were much lower than other countries, meanwhile Cu concentrations were much higher than other studies. Cadmium (Cd) and Lead (Pb) concentrations in the sampled rice were lower in comparison with their upper limits (0.1 and 0.2 mg kg(-1) for Cd and Pb, respectively) approved by Iranian Ministry of Health. Therefore, it can be concluded that there is no health problems result from Lorestan rice consumption, for these two elements.
Publisher: Elsevier NOTICE: this is the author's version of a work that was accepted for publicat... more Publisher: Elsevier NOTICE: this is the author's version of a work that was accepted for publication in Obesity Medicine. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Obesity Medicine, 14, (2019)
Nutrition Metabolism and Cardiovascular Diseases, Aug 1, 2018
BACKGROUND AND AIM The aim of this meta-analysis was to assess effects of alpha-lipoic acid suppl... more BACKGROUND AND AIM The aim of this meta-analysis was to assess effects of alpha-lipoic acid supplementation on C-reactive protein (CRP) levels in clinical trial studies. METHODS AND RESULTS A systematic search was carried out on clinical trial studies published in PubMed, ISI Web of Science, Cochrane Library and Scopus databases completed by manual search on reference list of eligible studies accomplished by November 4, 2017. Of a total number of 508 studies found in the first step of literature search, only 11 were included with 264 participants in supplementation groups and 287 in control groups. Estimated pooled random effects size analysis showed a significant reducing effect of alpha-lipoic acid supplementation on CRP level (-0.72 mg/l, 95% CI; -1.4, -0.04; P = 0.03) with a significant heterogeneity between the selected studies. Sub-group analysis showed that alpha-lipoic acid supplementation could significantly reduce serum CRP level when the baseline CRP level was greater than 3 mg/l (-1.02 mg/l, 95% CI: -1.3, -0.73) and when trial duration was >8 weeks (-0.99 mg/l, 95% CI: -1.29, -0.70). Results of subgroup analysis also showed that alpha lipoic acid supplementation could decrease CRP level only in non-diabetic patients (-1.02 mg/l, 95% CI: -1.31, -0.74). CONCLUSIONS Results of the current meta-analysis study showed that alpha-lipoic acid supplementation could significantly decrease CRP level in patients with elevated levels of this inflammatory marker.
Food Additives & Contaminants Part B-surveillance, Jun 1, 2010
In the present study ninety nine polished white rice samples were collected in three areas, all o... more In the present study ninety nine polished white rice samples were collected in three areas, all over Lorestan Province located in the west of Iran, and analysed for six elements by Flame Atomic Absorption Spectrometry (FAAS). For individual elements, Zinc (Zn) showed the highest concentration among the analysed essential elements with a mean of 28.6 mg kg(-1) and next to copper (Cu) of 22.8 mg kg(-1). Analysis of the essential and toxic elements for possible inter-area variation by ANOVA showed that there are significant differences between the areas. There was no significant difference between areas for Zn concentrations. Most of the samples nearly contained world wide average concentration of iron (Fe) and Zn in rice grains that were reported by various researches. But, the content of calcium (Ca) in the rice samples produced in Lorestan Province were much lower than other countries, meanwhile Cu concentrations were much higher than other studies. Cadmium (Cd) and Lead (Pb) concentrations in the sampled rice were lower in comparison with their upper limits (0.1 and 0.2 mg kg(-1) for Cd and Pb, respectively) approved by Iranian Ministry of Health. Therefore, it can be concluded that there is no health problems result from Lorestan rice consumption, for these two elements.
Food Additives & Contaminants Part B-surveillance, Jun 1, 2013
Tea (Camellia sinensis) is the most widely consumed beverage in several parts of the world. Tea c... more Tea (Camellia sinensis) is the most widely consumed beverage in several parts of the world. Tea consumption is a major component of the traditional Iranian diet; however, limited data are available indicating heavy metals content of this beverage. This study aimed to assess concentrations of heavy metals, including copper, lead, cadmium, chromium and mercury as well as minerals like zinc and iron in black tea samples. Atomic absorption spectrometry was used to determine the elements of interest in 20 brands of black tea that are widely consumed among Iranians. The mean concentrations were 28.8 for Zn, 135.2 for Fe, 15.9 for Cu and 8.2 for Cr (mg kg⁻¹) and 134.5 for Cd, 209.5 for Pb and 40 for Hg (µg kg⁻¹). It is concluded that tea consumption can be a possible source of some heavy metal intake for the Iranian population.
Journal of Food Science and Nutrition, Mar 31, 2020
Studies assessing the effect of vitamin C and E co-supplementation on levels of circulating C-rea... more Studies assessing the effect of vitamin C and E co-supplementation on levels of circulating C-reactive protein (CRP) show contradictory results. We carried out a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the effect of vitamin C and E co-supplementation on CRP. A systematic search was carried out using PubMed, Scopus, Ovid, Cochrane, Embase, and the Web of Science without any language or time restriction (until 31 March 2019) to retrieve RCTs that examined the effect of vitamin C and E co-supplementation on CRP. A meta-analysis was carried out using a random effects model, and I 2 indexes were used to evaluate the heterogeneity. The search yielded 5,134 publications, including 8 eligible RCTs. The results indicate that vitamin C and E co-supplementation does not significantly impact levels of serum CRP [weighted mean difference and 95% confidence interval with random effects model analysis: −0.22 mg/L (−0.85, 0.41), P=0.5]. Subgroup analysis demonstrated that vitamin C and E co-supplementation significantly reduced serum CRP in participants ≥30 years of age, but significantly increased serum CRP in participants <30 years of age. The results of this meta-analysis indicate beneficial effects of vitamins C and E co-supplementation on CRP in participants ≥30 years of age, and not in younger participants. To confirm these results, further well-designed RCTs are needed.
The aim of this meta-analysis was to assess effects of ginseng supplementation on CRP/hs-CRP leve... more The aim of this meta-analysis was to assess effects of ginseng supplementation on CRP/hs-CRP levels in clinical trial studies. Design: A systematic literature search was carried out for clinical trials published in ISI web of Science, Scopus, PubMed and Cochrane Library databases from the beginning to 16 th February 2018. Of 83 articles found in the first step of the systematic search, seven studies with nine arms included in this meta-analysis. Results: Results of pooled random-effect size analysis of nine trials showed non-significant decreasing effects of ginseng supplementation on CRP level (WMD:-0.1 mg/l, 95% CI,-0.26, 0.1; P = 0.27) with significant heterogeneity shown within the studies. The subgroup analysis showed that ginseng supplementation could significantly reduce CRP level by 0.51 (95% CI:-0.68,-0.34; P<0001, test for heterogeneity: P = 0.44, I 2 = 0.0%) in patients with a baseline serum CRP level of greater than 3 mg/dl. Trial duration and dose of ginseng supplementation included no significant effects on CRP level in this meta-analysis. Conclusion: Results of the current meta-analysis study have shown that ginseng supplementation can decrease significantly serum CRP/hsCRP levels in patients with elevated serum level of this inflammatory marker.
Diabetes Research and Clinical Practice, May 1, 2020
We aimed to investigate the effect of different dietary approaches on systolic and diastolic bloo... more We aimed to investigate the effect of different dietary approaches on systolic and diastolic blood pressure (SBP and DBP) in Type II diabetes (T2D). Methods: A systematic search was performed in Web of Science, PubMed, Scopus and Cochrane library without any language and time restriction up to December 2018, to retrieve the randomized controlled trials (RCTs) which examined the effects of different dietary approaches on SBP and DBP in T2D patients. Meta-analyses were carried out using a random effects model. I2 index was used to evaluate the heterogeneity. Results: Twenty four RCTs with 1130 patients were eligible. The dietary modifications were more effective in reducing both SBP and DBP vs. control diet. The Low-sodium, High-fiber, DASH, Low-fat, Low-protein and Vegan dietary approach were significantly more effective in reducing SBP compared to a control diet. The High-fiber, Low-fat, Low-protein and Vegan diet were significantly more effective in reducing DBP. The Low-sodium and High fiber diets had the greatest lowering effect on SBP and DBP in T2D patients. Conclusions: Adopting healthful dietary modifications were more effective in reducing both SBP and DBP vs. control. The High-fiber and Low-sodium diets had the greatest lowering effect on SBP and DBP in T2D.
Background: Food security is one of the main factors of individual and social health. It is of su... more Background: Food security is one of the main factors of individual and social health. It is of such importance that the World Bank and Food and Agriculture Organization (FAO) announced it as one of the Millennium Development Goals. This study aimed to report the prevalence of food insecurity in Iran. Methods: We searched English databases including; Scopus, Ovid, Web of Science, PubMed and Google Scholar and also Iranian databases; SID, Magiran and IranMedex for words Iran, food insecurity, and prevalence up to August 2015. The pooled food insecurity prevalence was calculated using Der-Simonian test. All analyses were performed using random effects model with 95% CI. We assessed heterogeneity of the studies using sub-group and meta-regression analyses. Results: A total of 31 studies were included. The prevalence of food insecurity was 49% among households (95% CI: %40-%59), 67% in children (95% CI: %63-%70), 61% in mothers (95% CI: %35-%88), 49% in adolescents (95% CI: %33-%66) and 65% in the elderly (95% CI: %44-%86). Conclusion: The prevalence of food insecurity is high in Iran. Fiscal policies should promote the nutritional knowledge of household members and also support the households to meet their nutritional needs. This plan should give priority to mid and low socioeconomic groups.
Chronic renal failure is a progressive and irreversible loss of kidney function, and the hemodial... more Chronic renal failure is a progressive and irreversible loss of kidney function, and the hemodialysis (HD) is one of the most common modalities in this regard. Oxidative stresses [like interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-α)] and inflammation are the main risk factors associated with cardiovascular diseases and other complications in many organs in hemodialysis patients; meanwhile, antioxidants like alpha lipoic acid (ALA) may reduce the oxidative stress markers and the levels of inflammatory cytokines, so can improve of the patient&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s quality of life. In this randomized clinical trial study, 60 HD patients were randomly categorized in two case and control groups. Case group received a daily capsule of 600 mg of ALA supplementation for 8 weeks, and the control group received placebo capsules daily. The serum level of IL-8 and TNF-α was measured in both groups before and after the intervention. There were no significant differences in age, gender, duration of dialysis, and causative factor for dialysis between both groups (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; 0.05). The mean of IL-8 and TNF-α after the intervention in case group was 26.20 ± 15.34 and 21.25 ± 9.61, respectively; the difference between both groups was not statistically significant (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; 0.05). Based on the better feeling and other beneficial effects of ALA were found in our study; we can conclude that it is a beneficial and recommended supplement, especially, for diabetic and dialysis patients.
Background: Dietary in ammatory index (DIP) is a new dietary index designed to evaluate individua... more Background: Dietary in ammatory index (DIP) is a new dietary index designed to evaluate individuals' diets. In addition, adhesion molecules are important biomarkers for assessing endothelium in ammation that they related to atherosclerosis and cardiovascular disease. Also, there is no study for assessing the association between adhesion molecules and DIP until now as well as other studies that assessed the relationship between dietary in ammatory index or DIP have controversy. The purpose of this crosssectional study was to determine the correlation between DII and endothelial markers such as E-selectin, intercellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1) among female nurses from Isfahan. In this study, dietary in ammatory potential (DIP) was used instead of DII. Methods: This study was performed on 420 healthy nurses. The nurses were selected by random cluster sampling method from private and public Isfahan hospitals. A validated food frequency questionnaire (FFQ) was applied to assess the dietary in ammatory potential. A fasting blood sample was collected for measuring the plasma levels of the endothelial markers and other variables. Results: After adjusting different potential confounders, no statistical association was found between DIP and sICAM-1, E-selectin and sVCAM-1 in model I (P=0.57, 0.98 and 0.45), model II (P=0.57, 0.98 and 0.45) and model III (P=0.67, 0.92 and 0.50) in comparison to the crude group (P=0.35, 0.83 and 0.49, respectively). Conclusions: The results revealed that the plasma levels of endothelial markers including E-selectin, sICAM-1, and sVCAM-1 were not signi cantly associated with DIP in female nurses.
International Journal for Vitamin and Nutrition Research, Sep 1, 2017
Vitamin E can reduce the level of lipid peroxidation and the related markers such as urine and pl... more Vitamin E can reduce the level of lipid peroxidation and the related markers such as urine and plasma levels of isoprostanes. However, effects of vitamin E supplementation on plasma and urine level of isoprostane F2α as markers of lipid peroxidation were conflicting in various clinical trials. The current meta-analysis was carried out to determine the effects of vitamin E supplementation on plasma and urine levels of isoprostanes F2α in randomized clinical trials. A systematic search of RCTs was carried out in PubMed, Scopus, Science Direct and Cochrane Library databases. OF 889 relevantly founded articles, only four articles with five arms met the criteria for meta-analysis of plasma level of isoprostanes F2α. For the urine level of isoprostane F2α, three studies with 14 arms were included in the meta-analysis. After pooled analyzing, a significant reduction of 6.98 ng / l was seen in plasma level of isoprostane F2α in vitamin E receiving group (95% CI = -11.2, -2.76; P &lt; 0.001) while no significant heterogeneity was seen between the studies included in this meta-analysis (P = 0.81 and I2 = 0.0%). However, the pooled effect of vitamin E supplementation on urine level of isoprostane F2α was not statistically significant (-11.31 pg / mg creatinine (95% CI = -26.4, 3.78; P = 0.88). Results of this meta-analysis have shown that vitamin E supplementation can only reduce plasma level of isoprostane F2α and has no significant effect on reducing urine level of this biomarker.
BMC complementary medicine and therapies, May 22, 2024
Background Several studies showed the hypoglycemic and hypolipidemic effects of Satureja Khuzesta... more Background Several studies showed the hypoglycemic and hypolipidemic effects of Satureja Khuzestanica (SK) in animal models. This study aimed to determine the effect of SK supplementation on glycemic and lipid outcomes of patients with type 2 diabetes mellitus (T2DM). Methods The study was designed as a double-blind, placebo-controlled, randomized clinical trial using block randomization. Seventy-eight T2DM patients were randomly assigned to intervention (n = 39) or placebo (n = 39) groups. They received SK or placebo in 500 mg capsules daily for 12 weeks. Anthropometric, blood pressure, liver enzymes, glycemic, and lipid outcomes were measured before and after the intervention. Results At baseline, there were no significant differences in age, sex, or glycated hemoglobin (HbA1c) levels between the groups. SK supplementation led to a significant decrease in FBS (-12.6 ± 20.7 mg/dl in the intervention group versus 3.5 ± 31.9 mg/dl; p = 0.007), HbA1c (-0.28 ± 0.45 in the intervention group versus 0.11 ± 0.54% in the placebo group; p = < 0.001), insulin (-1.65 ± 6.18 in the intervention group versus 2.09 ± 5.90 mIU/L in the placebo group; p = 0.03), total cholesterol (-14.6 ± 21.1 mg/dl in the intervention group versus 8.2 ± 30.9 mg/dl in the placebo group; p < 0.001), LDL-cholesterol (-4.6 ± 15.2 mg/dl in the intervention group versus 5.8 ± 14.6 mg/dl in placebo group; p < 0.001) levels, and significant increase in HDL-cholesterol (3.9 ± 4.9 mg/dl in the intervention group versus 0.9 ± 5.2 mg/dl in placebo group; p = 0.005). Conclusion Based on the study results, SK supplementation may improve glycemic indices and lipid profile of patients with T2DM. Our findings may provide novel complementary treatments without adverse effects for diabetes complications. These results need to be further confirmed in clinical trials. Registration : This trial has been registered in the Iranian Registry of Clinical Trials (IRCT ID: IRCT20190715044214N1, registration date: 21/02/2021).
3 fatty acids and vitamin E supplementation can affect gene expressions of SIRT1, FOXO1 and UCP-2... more 3 fatty acids and vitamin E supplementation can affect gene expressions of SIRT1, FOXO1 and UCP-2 in Coronary artery disease patients, Obesity Medicine,
Journal of Food Science and Nutrition, Sep 30, 2020
Dietary modification is an effective method for preventing and managing hypertension. Therefore, ... more Dietary modification is an effective method for preventing and managing hypertension. Therefore, we conducted a systematic review and meta-analysis to assess the effects of different dietary approaches for comparing high- and low-carbohydrate diets on systolic and diastolic blood pressure (SBP and DBP, respectively) in patients with type 2 diabetes mellitus (T2DM). We carried out a comprehensive literature search using PubMed, the Cochrane Library, Web of Science, and Scopus without any language and time restrictions until April, 2019. We carried out a meta-analysis using both fixed and random effects models where appropriate and used the I2 index to evaluate heterogeneity. We identified 16 eligible studies, with a total of 1,610 participants. The overall pooled net effect of different dietary approaches on SBP and DBP were −2.29 mmHg [95% confidence interval (CI): −3.49 to −1.1] and −1.03 mmHg (95% CI: −1.77 to −0.29), respectively, compared with high-carbohydrate diets. Indeed, diets high in monounsaturated fatty acids more effective in reducing both SBP and DBP than high-carbohydrate diets, whereas high-protein diets were not effective. Furthermore, we found that different dietary approaches, such as low-fat diets, did not reduce SBP or DBP to a greater extent than low-carbohydrate diets. Overall, the results of our meta-analysis show that diets high in monounsaturated fatty acids are more effective in reducing both SBP and DBP than diets high in carbohydrate, whereas other dietary approaches were not effective.
Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment, 2010
In the present study ninety nine polished white rice samples were collected in three areas, all o... more In the present study ninety nine polished white rice samples were collected in three areas, all over Lorestan Province located in the west of Iran, and analysed for six elements by Flame Atomic Absorption Spectrometry (FAAS). For individual elements, Zinc (Zn) showed the highest concentration among the analysed essential elements with a mean of 28.6 mg kg(-1) and next to copper (Cu) of 22.8 mg kg(-1). Analysis of the essential and toxic elements for possible inter-area variation by ANOVA showed that there are significant differences between the areas. There was no significant difference between areas for Zn concentrations. Most of the samples nearly contained world wide average concentration of iron (Fe) and Zn in rice grains that were reported by various researches. But, the content of calcium (Ca) in the rice samples produced in Lorestan Province were much lower than other countries, meanwhile Cu concentrations were much higher than other studies. Cadmium (Cd) and Lead (Pb) concentrations in the sampled rice were lower in comparison with their upper limits (0.1 and 0.2 mg kg(-1) for Cd and Pb, respectively) approved by Iranian Ministry of Health. Therefore, it can be concluded that there is no health problems result from Lorestan rice consumption, for these two elements.
Publisher: Elsevier NOTICE: this is the author's version of a work that was accepted for publicat... more Publisher: Elsevier NOTICE: this is the author's version of a work that was accepted for publication in Obesity Medicine. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Obesity Medicine, 14, (2019)
Nutrition Metabolism and Cardiovascular Diseases, Aug 1, 2018
BACKGROUND AND AIM The aim of this meta-analysis was to assess effects of alpha-lipoic acid suppl... more BACKGROUND AND AIM The aim of this meta-analysis was to assess effects of alpha-lipoic acid supplementation on C-reactive protein (CRP) levels in clinical trial studies. METHODS AND RESULTS A systematic search was carried out on clinical trial studies published in PubMed, ISI Web of Science, Cochrane Library and Scopus databases completed by manual search on reference list of eligible studies accomplished by November 4, 2017. Of a total number of 508 studies found in the first step of literature search, only 11 were included with 264 participants in supplementation groups and 287 in control groups. Estimated pooled random effects size analysis showed a significant reducing effect of alpha-lipoic acid supplementation on CRP level (-0.72 mg/l, 95% CI; -1.4, -0.04; P = 0.03) with a significant heterogeneity between the selected studies. Sub-group analysis showed that alpha-lipoic acid supplementation could significantly reduce serum CRP level when the baseline CRP level was greater than 3 mg/l (-1.02 mg/l, 95% CI: -1.3, -0.73) and when trial duration was >8 weeks (-0.99 mg/l, 95% CI: -1.29, -0.70). Results of subgroup analysis also showed that alpha lipoic acid supplementation could decrease CRP level only in non-diabetic patients (-1.02 mg/l, 95% CI: -1.31, -0.74). CONCLUSIONS Results of the current meta-analysis study showed that alpha-lipoic acid supplementation could significantly decrease CRP level in patients with elevated levels of this inflammatory marker.
Food Additives & Contaminants Part B-surveillance, Jun 1, 2010
In the present study ninety nine polished white rice samples were collected in three areas, all o... more In the present study ninety nine polished white rice samples were collected in three areas, all over Lorestan Province located in the west of Iran, and analysed for six elements by Flame Atomic Absorption Spectrometry (FAAS). For individual elements, Zinc (Zn) showed the highest concentration among the analysed essential elements with a mean of 28.6 mg kg(-1) and next to copper (Cu) of 22.8 mg kg(-1). Analysis of the essential and toxic elements for possible inter-area variation by ANOVA showed that there are significant differences between the areas. There was no significant difference between areas for Zn concentrations. Most of the samples nearly contained world wide average concentration of iron (Fe) and Zn in rice grains that were reported by various researches. But, the content of calcium (Ca) in the rice samples produced in Lorestan Province were much lower than other countries, meanwhile Cu concentrations were much higher than other studies. Cadmium (Cd) and Lead (Pb) concentrations in the sampled rice were lower in comparison with their upper limits (0.1 and 0.2 mg kg(-1) for Cd and Pb, respectively) approved by Iranian Ministry of Health. Therefore, it can be concluded that there is no health problems result from Lorestan rice consumption, for these two elements.
Food Additives & Contaminants Part B-surveillance, Jun 1, 2013
Tea (Camellia sinensis) is the most widely consumed beverage in several parts of the world. Tea c... more Tea (Camellia sinensis) is the most widely consumed beverage in several parts of the world. Tea consumption is a major component of the traditional Iranian diet; however, limited data are available indicating heavy metals content of this beverage. This study aimed to assess concentrations of heavy metals, including copper, lead, cadmium, chromium and mercury as well as minerals like zinc and iron in black tea samples. Atomic absorption spectrometry was used to determine the elements of interest in 20 brands of black tea that are widely consumed among Iranians. The mean concentrations were 28.8 for Zn, 135.2 for Fe, 15.9 for Cu and 8.2 for Cr (mg kg⁻¹) and 134.5 for Cd, 209.5 for Pb and 40 for Hg (µg kg⁻¹). It is concluded that tea consumption can be a possible source of some heavy metal intake for the Iranian population.
Journal of Food Science and Nutrition, Mar 31, 2020
Studies assessing the effect of vitamin C and E co-supplementation on levels of circulating C-rea... more Studies assessing the effect of vitamin C and E co-supplementation on levels of circulating C-reactive protein (CRP) show contradictory results. We carried out a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the effect of vitamin C and E co-supplementation on CRP. A systematic search was carried out using PubMed, Scopus, Ovid, Cochrane, Embase, and the Web of Science without any language or time restriction (until 31 March 2019) to retrieve RCTs that examined the effect of vitamin C and E co-supplementation on CRP. A meta-analysis was carried out using a random effects model, and I 2 indexes were used to evaluate the heterogeneity. The search yielded 5,134 publications, including 8 eligible RCTs. The results indicate that vitamin C and E co-supplementation does not significantly impact levels of serum CRP [weighted mean difference and 95% confidence interval with random effects model analysis: −0.22 mg/L (−0.85, 0.41), P=0.5]. Subgroup analysis demonstrated that vitamin C and E co-supplementation significantly reduced serum CRP in participants ≥30 years of age, but significantly increased serum CRP in participants <30 years of age. The results of this meta-analysis indicate beneficial effects of vitamins C and E co-supplementation on CRP in participants ≥30 years of age, and not in younger participants. To confirm these results, further well-designed RCTs are needed.
The aim of this meta-analysis was to assess effects of ginseng supplementation on CRP/hs-CRP leve... more The aim of this meta-analysis was to assess effects of ginseng supplementation on CRP/hs-CRP levels in clinical trial studies. Design: A systematic literature search was carried out for clinical trials published in ISI web of Science, Scopus, PubMed and Cochrane Library databases from the beginning to 16 th February 2018. Of 83 articles found in the first step of the systematic search, seven studies with nine arms included in this meta-analysis. Results: Results of pooled random-effect size analysis of nine trials showed non-significant decreasing effects of ginseng supplementation on CRP level (WMD:-0.1 mg/l, 95% CI,-0.26, 0.1; P = 0.27) with significant heterogeneity shown within the studies. The subgroup analysis showed that ginseng supplementation could significantly reduce CRP level by 0.51 (95% CI:-0.68,-0.34; P<0001, test for heterogeneity: P = 0.44, I 2 = 0.0%) in patients with a baseline serum CRP level of greater than 3 mg/dl. Trial duration and dose of ginseng supplementation included no significant effects on CRP level in this meta-analysis. Conclusion: Results of the current meta-analysis study have shown that ginseng supplementation can decrease significantly serum CRP/hsCRP levels in patients with elevated serum level of this inflammatory marker.
Diabetes Research and Clinical Practice, May 1, 2020
We aimed to investigate the effect of different dietary approaches on systolic and diastolic bloo... more We aimed to investigate the effect of different dietary approaches on systolic and diastolic blood pressure (SBP and DBP) in Type II diabetes (T2D). Methods: A systematic search was performed in Web of Science, PubMed, Scopus and Cochrane library without any language and time restriction up to December 2018, to retrieve the randomized controlled trials (RCTs) which examined the effects of different dietary approaches on SBP and DBP in T2D patients. Meta-analyses were carried out using a random effects model. I2 index was used to evaluate the heterogeneity. Results: Twenty four RCTs with 1130 patients were eligible. The dietary modifications were more effective in reducing both SBP and DBP vs. control diet. The Low-sodium, High-fiber, DASH, Low-fat, Low-protein and Vegan dietary approach were significantly more effective in reducing SBP compared to a control diet. The High-fiber, Low-fat, Low-protein and Vegan diet were significantly more effective in reducing DBP. The Low-sodium and High fiber diets had the greatest lowering effect on SBP and DBP in T2D patients. Conclusions: Adopting healthful dietary modifications were more effective in reducing both SBP and DBP vs. control. The High-fiber and Low-sodium diets had the greatest lowering effect on SBP and DBP in T2D.
Background: Food security is one of the main factors of individual and social health. It is of su... more Background: Food security is one of the main factors of individual and social health. It is of such importance that the World Bank and Food and Agriculture Organization (FAO) announced it as one of the Millennium Development Goals. This study aimed to report the prevalence of food insecurity in Iran. Methods: We searched English databases including; Scopus, Ovid, Web of Science, PubMed and Google Scholar and also Iranian databases; SID, Magiran and IranMedex for words Iran, food insecurity, and prevalence up to August 2015. The pooled food insecurity prevalence was calculated using Der-Simonian test. All analyses were performed using random effects model with 95% CI. We assessed heterogeneity of the studies using sub-group and meta-regression analyses. Results: A total of 31 studies were included. The prevalence of food insecurity was 49% among households (95% CI: %40-%59), 67% in children (95% CI: %63-%70), 61% in mothers (95% CI: %35-%88), 49% in adolescents (95% CI: %33-%66) and 65% in the elderly (95% CI: %44-%86). Conclusion: The prevalence of food insecurity is high in Iran. Fiscal policies should promote the nutritional knowledge of household members and also support the households to meet their nutritional needs. This plan should give priority to mid and low socioeconomic groups.
Chronic renal failure is a progressive and irreversible loss of kidney function, and the hemodial... more Chronic renal failure is a progressive and irreversible loss of kidney function, and the hemodialysis (HD) is one of the most common modalities in this regard. Oxidative stresses [like interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-α)] and inflammation are the main risk factors associated with cardiovascular diseases and other complications in many organs in hemodialysis patients; meanwhile, antioxidants like alpha lipoic acid (ALA) may reduce the oxidative stress markers and the levels of inflammatory cytokines, so can improve of the patient&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s quality of life. In this randomized clinical trial study, 60 HD patients were randomly categorized in two case and control groups. Case group received a daily capsule of 600 mg of ALA supplementation for 8 weeks, and the control group received placebo capsules daily. The serum level of IL-8 and TNF-α was measured in both groups before and after the intervention. There were no significant differences in age, gender, duration of dialysis, and causative factor for dialysis between both groups (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; 0.05). The mean of IL-8 and TNF-α after the intervention in case group was 26.20 ± 15.34 and 21.25 ± 9.61, respectively; the difference between both groups was not statistically significant (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; 0.05). Based on the better feeling and other beneficial effects of ALA were found in our study; we can conclude that it is a beneficial and recommended supplement, especially, for diabetic and dialysis patients.
Background: Dietary in ammatory index (DIP) is a new dietary index designed to evaluate individua... more Background: Dietary in ammatory index (DIP) is a new dietary index designed to evaluate individuals' diets. In addition, adhesion molecules are important biomarkers for assessing endothelium in ammation that they related to atherosclerosis and cardiovascular disease. Also, there is no study for assessing the association between adhesion molecules and DIP until now as well as other studies that assessed the relationship between dietary in ammatory index or DIP have controversy. The purpose of this crosssectional study was to determine the correlation between DII and endothelial markers such as E-selectin, intercellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1) among female nurses from Isfahan. In this study, dietary in ammatory potential (DIP) was used instead of DII. Methods: This study was performed on 420 healthy nurses. The nurses were selected by random cluster sampling method from private and public Isfahan hospitals. A validated food frequency questionnaire (FFQ) was applied to assess the dietary in ammatory potential. A fasting blood sample was collected for measuring the plasma levels of the endothelial markers and other variables. Results: After adjusting different potential confounders, no statistical association was found between DIP and sICAM-1, E-selectin and sVCAM-1 in model I (P=0.57, 0.98 and 0.45), model II (P=0.57, 0.98 and 0.45) and model III (P=0.67, 0.92 and 0.50) in comparison to the crude group (P=0.35, 0.83 and 0.49, respectively). Conclusions: The results revealed that the plasma levels of endothelial markers including E-selectin, sICAM-1, and sVCAM-1 were not signi cantly associated with DIP in female nurses.
International Journal for Vitamin and Nutrition Research, Sep 1, 2017
Vitamin E can reduce the level of lipid peroxidation and the related markers such as urine and pl... more Vitamin E can reduce the level of lipid peroxidation and the related markers such as urine and plasma levels of isoprostanes. However, effects of vitamin E supplementation on plasma and urine level of isoprostane F2α as markers of lipid peroxidation were conflicting in various clinical trials. The current meta-analysis was carried out to determine the effects of vitamin E supplementation on plasma and urine levels of isoprostanes F2α in randomized clinical trials. A systematic search of RCTs was carried out in PubMed, Scopus, Science Direct and Cochrane Library databases. OF 889 relevantly founded articles, only four articles with five arms met the criteria for meta-analysis of plasma level of isoprostanes F2α. For the urine level of isoprostane F2α, three studies with 14 arms were included in the meta-analysis. After pooled analyzing, a significant reduction of 6.98 ng / l was seen in plasma level of isoprostane F2α in vitamin E receiving group (95% CI = -11.2, -2.76; P &lt; 0.001) while no significant heterogeneity was seen between the studies included in this meta-analysis (P = 0.81 and I2 = 0.0%). However, the pooled effect of vitamin E supplementation on urine level of isoprostane F2α was not statistically significant (-11.31 pg / mg creatinine (95% CI = -26.4, 3.78; P = 0.88). Results of this meta-analysis have shown that vitamin E supplementation can only reduce plasma level of isoprostane F2α and has no significant effect on reducing urine level of this biomarker.
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