Journal of Applied Life Sciences International, 2021
Some Sulfanoquinoxaline-2,3-diones hydrazone derivatives (1-8) were synthesized from the reaction... more Some Sulfanoquinoxaline-2,3-diones hydrazone derivatives (1-8) were synthesized from the reactions of 2,3-dioxoquinoxaline-6-sulfonohydrazine with seven substituted benzaldehydes and acetophenone. All the synthesized compounds were biologically evaluated against cholinesterase’s (acetylcholinesterase and butyryl cholinesterase). Compounds 1-8 were found to be a good selective inhibitor for acetylcholinesterase and butyryl cholinesterase. Among the series, compounds 3 (IC50 = 75 ± 10 µg/mL) and 5 (IC50 = 80 ± 10 µg/mL) were found to be the most active inhibitors against acetylcholinesterase, while compounds 6 (IC50 = 110 ± 10 µg/mL), 8 (IC50 = 130 ± 10 µg/mL) and 7 (IC50 = 150 ± 10 µg/mL), were found to be most active inhibitor against butyryl cholinesterase. The IC50 values for all the synthesized compounds were lower than standard, eserine (IC50 = 70 ± 20 µg/mL). Their considerable acetylcholinesterase and butyryl cholinesterase inhibitory activities make them a good candidate for ...
Journal of Pharmaceutical Research International, 2021
Aims: This studies aims at the synthesis of new heterocyclic systems and study its biological and... more Aims: This studies aims at the synthesis of new heterocyclic systems and study its biological and pharmacological properties. Objective: This study was designed to synthesized some quinoxaline-2,3-dione with sulfonamide moiety, characterize the synthesized compounds, and study the antimicrobial properties of the synthesized compounds on some bacterial strains. Materials and Methods: Six quinoxaline-6-sulfonohydrazone derivatives were synthesized by reacting quinoxaline-6-sulfonohydrazine with some substituted benzaldehydes and ketones. The compounds were tested for their potential antibacterial properties. Results: All the test compounds possessed promising antibacterial property against a panel of bacterial strains used for this study. The MIC values exhibited by these compounds ranged between 0.0313 and 0.250 mg/mL. Among the compounds tested, compound 2 showed appreciable antibacterial activity. Discussion and Conclusion: The study concluded that all the compounds exhibited appre...
Journal of Pharmaceutical Research International, 2021
Aims: To synthesize some phthalimides derivatives and evaluate the compounds for their possible b... more Aims: To synthesize some phthalimides derivatives and evaluate the compounds for their possible biological properties. Methods: The substituted phenylisoindoline-1,3-dione were synthesized from the reactions of N-phenyl phthalimide with different substituted aromatic aldehyde. The synthesized compounds were characterized using nuclear magnetic resonance spectroscopic analysis. The acetylcholinesterase and butyryl cholinesterase inhibitions were determined by Spectro photochemical analysis of acetylthiocholine and butyryl choline chloride. Results: Compounds 6 (IC50 = 30±3 µg/mL) and 4 (IC50 = 141±60 µg/mL) were found to be the most active inhibitors against acetylcholinesterase, while compounds 4 (IC50 = 102±10 µg/mL), 5 (IC50 = 105 ± 20 µg/mL) and 2 (IC50 = 190 ± 10 µg/mL), were found to be most active inhibitor against butyryl cholinesterase. Conclusion: The considerable acetylcholinesterase and butyryl cholinesterase inhibitory activities of the synthesized compounds makes them g...
Aims: This aims of this study was to synthesis new quinoxaline-based heterocycles and study its a... more Aims: This aims of this study was to synthesis new quinoxaline-based heterocycles and study its antibacterial properties. Objective: This study was designed to synthesis some 3-methyl-6-nitroquinoxaline-2-one with hydrazine moiety, characterize the synthesized compounds, and study their antibacterial properties on some bacterial strains. Materials and Methods: Six 3-methylquinoxaline-2-hydrazone derivatives were synthesized by reacting 2-hydrazinyl-3-methyl-6-nitroquinoxaline with various substituted acetophenones. The hydrazones were screened for their potential antibacterial properties. Results: All the test compounds were found to possessed promising antibacterial properties against a panel of bacterial strains screened for this study. The MIC values exhibited by these compounds ranged between 0.0313 and 0.250 mg/mL. The lowest MBC of the compounds against the test organism was 0.0625 mg/mL while the highest MBC was 0.250 mg/mL. Discussion and Conclusion: The study concluded that...
Eight quinoxalinone derivatives were synthesized and investigated for some neuropharmacological e... more Eight quinoxalinone derivatives were synthesized and investigated for some neuropharmacological effects (analgesia, sedation, convulsion, anxiety, memory and psychosis) in mice and rats. In the CNS depressant activity, N,N-dibenzyl-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide is the most active, while the other compounds appear variously dose-dependent. Only three of the compounds showed anxiolytic effect, with N,N-dibenzyl-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide showing the highest activity at 2.5 mg/kg. At the dose of 30 mg/kg, 6-nitro-1,4-dihydroquinoxaline-2,3-dione showed a better anxiolytic effect in mice than diazepam (dose: 1 mg/kg), while 1,2,3,4-tetrahydroquinoxaline-2,3-dione (dose: 25 mg/kg) showed a comparative effect to diazepam. 6-Chloro-1,4-dihydro-quinoxaline-2,3-dione and N,N-dibenzyl-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonamideshowed significant anticonvulsant action. None of the compounds showed any analgesic or antidopaminergic ef...
Investments on the capital market depends on the current political situation of the country, as w... more Investments on the capital market depends on the current political situation of the country, as well as on the movements of the global economy. In countries with unstable political situation, the performance of the stock exchange declines, unlike politically stable countries, where stock exchange operation is carried out continuously, the stock exchange is a mirror and a barometer of general developments in a society. The economic crisis that spread all around the world in 2008, triggered the strongest negative effect on the capital markets, both on the trading volume and on securities' prices. Prices of securities were falling overnight and stock indices also. In most cases an absurd situation occurred, where although companies showed good financial results and had promising investment activities, stock prices were still falling because of the euphoric panic that investors would lose their ventures, so they sought to take the last chance to save what can be saved.
Journal of Pharmaceutical Research International, 2019
Aim: To evaluate the antimicrobial and antioxidant activities of bioactive compounds isolated fro... more Aim: To evaluate the antimicrobial and antioxidant activities of bioactive compounds isolated from Annona muricata (Linn.) leaf extract. Study Design: In vitro antimicrobial assay of bioactive compounds isolated from solvent fractions of plant leaf extract against selected clinical bacterial and fungal isolates. Antioxidant assay of plant leaf extract. Place and Duration of Study: All the work was carried out in the Departments of Chemistry and Microbiology, Obafemi Awolowo University, Ile-Ife, Nigeria between March, 2015 and January, 2016. Methodology: Isolation of bioactive compounds was by column and thin layer chromatographic techniques. Isolated compounds were characterized by nuclear magnetic resonance spectroscopic analysis. Antimicrobial activities were evaluated by disc diffusion and broth microdilution methods while antioxidant activity was investigated using the 2,2-dipheny-1-picrylhydrazyl (DPPH) radical-scavenging assay. Results: Two compounds kaempferol-3-O-glucoside (...
Jute (Corchorus spp) can be a potential medicinal product for the treatment of many diseases. In ... more Jute (Corchorus spp) can be a potential medicinal product for the treatment of many diseases. In traditional medicinal practices, it is used to treat constipation, demulcent, dysentery, worm, carminative anthalmitic, intestinal antiseptic, ascites, pain, piles, tumors, dysuria, febrifuge, stomachic, cystitis etc. Till now more than 80 compounds, including glycosides, triterpenes, ionones, phenolics, phytosterols, organic acids, lignins, alkaloids have been isolated and identified from jute plant. The main phytochemical compounds are cardiac glycosides, corchorin, corchotoxin, helveticoside, corchoroside A and B, olitoriside, erysimoside, straphatidol, glycoside, capsularinsteroids and many other secondary metabolites. Modern studies have revealed several biological activities such as acidic polysaccharide, cardiotonic, anti-obisity, gastroprotective, antidiabetcs, antioxidant, anti-inflammatory and cytotoxic activities. The present review deals to provide comprehensive knowledge on ...
International Journal of Sciences: Basic and Applied Research, 2015
Annona muricata is used traditionally in the treatment of several human ailments. In the present ... more Annona muricata is used traditionally in the treatment of several human ailments. In the present study, the biocidal activities of A. muricata leaf extracts were evaluated against 10 clinical strains of bacteria and 6 fungal strains. The antimicrobial activity was determined by the disc diffusion method. The ethyl acetate fraction of the leaf extract produced the greatest antibacterial activity (mean zones of inhibition range 27.6 ± 1.2 to 31.3 ± 1.5 mm) followed by the n-butanol fraction (mean zones of inhibition range 21.0 ± 1.7 to 30.3 ± 1.5 mm). However, the n-butanol fraction exhibited the greatest antifungal effect. Minimum inhibitory concentrations (MIC) of the two best fractions were determined by the broth microdilution method. The MIC values for the ethyl acetate and n-butanol fractions ranged from 0.0313 to 0.0125 µg/ml and 0.0625 to 0.125 µg/ml respectively. The ethyl acetate fraction also exhibited remarkable bactericidal activity against Enterococcus faecalis and Bacil...
Ludwigia abyssinica and Ludwigia decurrens are two plant species of the genus Ludwigiaused tradit... more Ludwigia abyssinica and Ludwigia decurrens are two plant species of the genus Ludwigiaused traditionally for the treatment of various skin, gastrointestinal, wound and bone joint disorders in Nigeria. The antibacterial and antifungal properties of extracts from the leaves of both plants against clinically important species of bacteria and fungi were examined. The two plant species produced activities with absolute similarity. The n-butanol extract was the most potent with maximum zone of inhibition (32.0 mm) followed by the ethyl acetate extract (12.0 to 31.0 mm) amongst other extracts (aqueous, dichloromethane and n-hexane). The n-butanol extract exhibited broad spectrum activity against all test bacteria and fungi and compared favourably with standard reference drugs – ampicillin, streptomycin and amphotericin B. The minimum inhibitory concentrations (MIC) exhibited by both n-butanol and ethyl acetate extracts against test bacteria species ranged between 0.625 to 5.0 mg ml-1 and 1...
Journal of Applied Life Sciences International, 2021
Some Sulfanoquinoxaline-2,3-diones hydrazone derivatives (1-8) were synthesized from the reaction... more Some Sulfanoquinoxaline-2,3-diones hydrazone derivatives (1-8) were synthesized from the reactions of 2,3-dioxoquinoxaline-6-sulfonohydrazine with seven substituted benzaldehydes and acetophenone. All the synthesized compounds were biologically evaluated against cholinesterase’s (acetylcholinesterase and butyryl cholinesterase). Compounds 1-8 were found to be a good selective inhibitor for acetylcholinesterase and butyryl cholinesterase. Among the series, compounds 3 (IC50 = 75 ± 10 µg/mL) and 5 (IC50 = 80 ± 10 µg/mL) were found to be the most active inhibitors against acetylcholinesterase, while compounds 6 (IC50 = 110 ± 10 µg/mL), 8 (IC50 = 130 ± 10 µg/mL) and 7 (IC50 = 150 ± 10 µg/mL), were found to be most active inhibitor against butyryl cholinesterase. The IC50 values for all the synthesized compounds were lower than standard, eserine (IC50 = 70 ± 20 µg/mL). Their considerable acetylcholinesterase and butyryl cholinesterase inhibitory activities make them a good candidate for ...
Journal of Pharmaceutical Research International, 2021
Aims: This studies aims at the synthesis of new heterocyclic systems and study its biological and... more Aims: This studies aims at the synthesis of new heterocyclic systems and study its biological and pharmacological properties. Objective: This study was designed to synthesized some quinoxaline-2,3-dione with sulfonamide moiety, characterize the synthesized compounds, and study the antimicrobial properties of the synthesized compounds on some bacterial strains. Materials and Methods: Six quinoxaline-6-sulfonohydrazone derivatives were synthesized by reacting quinoxaline-6-sulfonohydrazine with some substituted benzaldehydes and ketones. The compounds were tested for their potential antibacterial properties. Results: All the test compounds possessed promising antibacterial property against a panel of bacterial strains used for this study. The MIC values exhibited by these compounds ranged between 0.0313 and 0.250 mg/mL. Among the compounds tested, compound 2 showed appreciable antibacterial activity. Discussion and Conclusion: The study concluded that all the compounds exhibited appre...
Journal of Pharmaceutical Research International, 2021
Aims: To synthesize some phthalimides derivatives and evaluate the compounds for their possible b... more Aims: To synthesize some phthalimides derivatives and evaluate the compounds for their possible biological properties. Methods: The substituted phenylisoindoline-1,3-dione were synthesized from the reactions of N-phenyl phthalimide with different substituted aromatic aldehyde. The synthesized compounds were characterized using nuclear magnetic resonance spectroscopic analysis. The acetylcholinesterase and butyryl cholinesterase inhibitions were determined by Spectro photochemical analysis of acetylthiocholine and butyryl choline chloride. Results: Compounds 6 (IC50 = 30±3 µg/mL) and 4 (IC50 = 141±60 µg/mL) were found to be the most active inhibitors against acetylcholinesterase, while compounds 4 (IC50 = 102±10 µg/mL), 5 (IC50 = 105 ± 20 µg/mL) and 2 (IC50 = 190 ± 10 µg/mL), were found to be most active inhibitor against butyryl cholinesterase. Conclusion: The considerable acetylcholinesterase and butyryl cholinesterase inhibitory activities of the synthesized compounds makes them g...
Aims: This aims of this study was to synthesis new quinoxaline-based heterocycles and study its a... more Aims: This aims of this study was to synthesis new quinoxaline-based heterocycles and study its antibacterial properties. Objective: This study was designed to synthesis some 3-methyl-6-nitroquinoxaline-2-one with hydrazine moiety, characterize the synthesized compounds, and study their antibacterial properties on some bacterial strains. Materials and Methods: Six 3-methylquinoxaline-2-hydrazone derivatives were synthesized by reacting 2-hydrazinyl-3-methyl-6-nitroquinoxaline with various substituted acetophenones. The hydrazones were screened for their potential antibacterial properties. Results: All the test compounds were found to possessed promising antibacterial properties against a panel of bacterial strains screened for this study. The MIC values exhibited by these compounds ranged between 0.0313 and 0.250 mg/mL. The lowest MBC of the compounds against the test organism was 0.0625 mg/mL while the highest MBC was 0.250 mg/mL. Discussion and Conclusion: The study concluded that...
Eight quinoxalinone derivatives were synthesized and investigated for some neuropharmacological e... more Eight quinoxalinone derivatives were synthesized and investigated for some neuropharmacological effects (analgesia, sedation, convulsion, anxiety, memory and psychosis) in mice and rats. In the CNS depressant activity, N,N-dibenzyl-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide is the most active, while the other compounds appear variously dose-dependent. Only three of the compounds showed anxiolytic effect, with N,N-dibenzyl-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide showing the highest activity at 2.5 mg/kg. At the dose of 30 mg/kg, 6-nitro-1,4-dihydroquinoxaline-2,3-dione showed a better anxiolytic effect in mice than diazepam (dose: 1 mg/kg), while 1,2,3,4-tetrahydroquinoxaline-2,3-dione (dose: 25 mg/kg) showed a comparative effect to diazepam. 6-Chloro-1,4-dihydro-quinoxaline-2,3-dione and N,N-dibenzyl-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonamideshowed significant anticonvulsant action. None of the compounds showed any analgesic or antidopaminergic ef...
Investments on the capital market depends on the current political situation of the country, as w... more Investments on the capital market depends on the current political situation of the country, as well as on the movements of the global economy. In countries with unstable political situation, the performance of the stock exchange declines, unlike politically stable countries, where stock exchange operation is carried out continuously, the stock exchange is a mirror and a barometer of general developments in a society. The economic crisis that spread all around the world in 2008, triggered the strongest negative effect on the capital markets, both on the trading volume and on securities' prices. Prices of securities were falling overnight and stock indices also. In most cases an absurd situation occurred, where although companies showed good financial results and had promising investment activities, stock prices were still falling because of the euphoric panic that investors would lose their ventures, so they sought to take the last chance to save what can be saved.
Journal of Pharmaceutical Research International, 2019
Aim: To evaluate the antimicrobial and antioxidant activities of bioactive compounds isolated fro... more Aim: To evaluate the antimicrobial and antioxidant activities of bioactive compounds isolated from Annona muricata (Linn.) leaf extract. Study Design: In vitro antimicrobial assay of bioactive compounds isolated from solvent fractions of plant leaf extract against selected clinical bacterial and fungal isolates. Antioxidant assay of plant leaf extract. Place and Duration of Study: All the work was carried out in the Departments of Chemistry and Microbiology, Obafemi Awolowo University, Ile-Ife, Nigeria between March, 2015 and January, 2016. Methodology: Isolation of bioactive compounds was by column and thin layer chromatographic techniques. Isolated compounds were characterized by nuclear magnetic resonance spectroscopic analysis. Antimicrobial activities were evaluated by disc diffusion and broth microdilution methods while antioxidant activity was investigated using the 2,2-dipheny-1-picrylhydrazyl (DPPH) radical-scavenging assay. Results: Two compounds kaempferol-3-O-glucoside (...
Jute (Corchorus spp) can be a potential medicinal product for the treatment of many diseases. In ... more Jute (Corchorus spp) can be a potential medicinal product for the treatment of many diseases. In traditional medicinal practices, it is used to treat constipation, demulcent, dysentery, worm, carminative anthalmitic, intestinal antiseptic, ascites, pain, piles, tumors, dysuria, febrifuge, stomachic, cystitis etc. Till now more than 80 compounds, including glycosides, triterpenes, ionones, phenolics, phytosterols, organic acids, lignins, alkaloids have been isolated and identified from jute plant. The main phytochemical compounds are cardiac glycosides, corchorin, corchotoxin, helveticoside, corchoroside A and B, olitoriside, erysimoside, straphatidol, glycoside, capsularinsteroids and many other secondary metabolites. Modern studies have revealed several biological activities such as acidic polysaccharide, cardiotonic, anti-obisity, gastroprotective, antidiabetcs, antioxidant, anti-inflammatory and cytotoxic activities. The present review deals to provide comprehensive knowledge on ...
International Journal of Sciences: Basic and Applied Research, 2015
Annona muricata is used traditionally in the treatment of several human ailments. In the present ... more Annona muricata is used traditionally in the treatment of several human ailments. In the present study, the biocidal activities of A. muricata leaf extracts were evaluated against 10 clinical strains of bacteria and 6 fungal strains. The antimicrobial activity was determined by the disc diffusion method. The ethyl acetate fraction of the leaf extract produced the greatest antibacterial activity (mean zones of inhibition range 27.6 ± 1.2 to 31.3 ± 1.5 mm) followed by the n-butanol fraction (mean zones of inhibition range 21.0 ± 1.7 to 30.3 ± 1.5 mm). However, the n-butanol fraction exhibited the greatest antifungal effect. Minimum inhibitory concentrations (MIC) of the two best fractions were determined by the broth microdilution method. The MIC values for the ethyl acetate and n-butanol fractions ranged from 0.0313 to 0.0125 µg/ml and 0.0625 to 0.125 µg/ml respectively. The ethyl acetate fraction also exhibited remarkable bactericidal activity against Enterococcus faecalis and Bacil...
Ludwigia abyssinica and Ludwigia decurrens are two plant species of the genus Ludwigiaused tradit... more Ludwigia abyssinica and Ludwigia decurrens are two plant species of the genus Ludwigiaused traditionally for the treatment of various skin, gastrointestinal, wound and bone joint disorders in Nigeria. The antibacterial and antifungal properties of extracts from the leaves of both plants against clinically important species of bacteria and fungi were examined. The two plant species produced activities with absolute similarity. The n-butanol extract was the most potent with maximum zone of inhibition (32.0 mm) followed by the ethyl acetate extract (12.0 to 31.0 mm) amongst other extracts (aqueous, dichloromethane and n-hexane). The n-butanol extract exhibited broad spectrum activity against all test bacteria and fungi and compared favourably with standard reference drugs – ampicillin, streptomycin and amphotericin B. The minimum inhibitory concentrations (MIC) exhibited by both n-butanol and ethyl acetate extracts against test bacteria species ranged between 0.625 to 5.0 mg ml-1 and 1...
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Papers by Festus Taiwo