To characterize temporal exposure and elimination of 5 gold/dendrimer composite nanodevices (CNDs... more To characterize temporal exposure and elimination of 5 gold/dendrimer composite nanodevices (CNDs) (5 nm positive, negative, and neutral, 11 nm negative, 22 nm positive) in mice using a physiologically based mathematical model. 400 ug of CNDs is injected intravenously to mice bearing melanoma cell lines. Gold content is determined from plasma and tissue samples using neutron activation analysis. A physiologically based pharmacokinetic (PBPK) model is developed for 5 nm positive, negative, and neutral and 11 nm negative nanoparticles and extrapolated to 22 nm positive particles. A global sensitivity analysis is performed for estimated model parameters. Negative and neutral particles exhibited similar distribution profiles. Unique model parameter estimates and distribution profiles explain similarities and differences relative to positive particles. The model also explains mechanisms of elimination by kidney and reticuloendothelial uptake in liver and spleen, which varies with particle size and charge. Since the PBPK model can capture the diverse temporal profiles of non-targeted nanoparticles, we propose that when specific binding ligands are lacking, size and charge of nanodevices govern most of their in vivo interactions.
Instrumental neutron activation analysis (INAA) is one of the most widely used analytical methods... more Instrumental neutron activation analysis (INAA) is one of the most widely used analytical methods for bulk chemical characterization of ceramic pastes, owing to its relatively simple sample preparation procedures, the small sample mass required, and low detection limits for most elements of interest. At least fifty major, minor, and trace elements spanning the main geochemical element groups can be readily determined to the percent, ppm or ppb level, although sensitivity varies by element. In this chapter we provide an overview of the fundamental principles of activation analysis, and describe the steps typically followed in sample preparation, irradiation, gamma spectroscopy, and elemental analysis. In addition, we detail the strengths and weaknesses of INAA for archaeological ceramic studies, and illustrate a few of the many applications that have made INAA the mainstay for studies involving ceramic provenance, the organization of pottery production, and ceramic technology.
Page 1. POLITICAL ECONOMY AND MARKET ECONOMY UNDER AZTEC RULE: A REGIONAL PERSPECTIVE BASED ON DE... more Page 1. POLITICAL ECONOMY AND MARKET ECONOMY UNDER AZTEC RULE: A REGIONAL PERSPECTIVE BASED ON DECORATED CERAMIC PRODUCTION AND DISTRIBUTION SYSTEMS IN THE VALLEY OF MEXICO Volume I by Leah Delia Minc ...
To characterize temporal exposure and elimination of 5 gold/dendrimer composite nanodevices (CNDs... more To characterize temporal exposure and elimination of 5 gold/dendrimer composite nanodevices (CNDs) (5 nm positive, negative, and neutral, 11 nm negative, 22 nm positive) in mice using a physiologically based mathematical model. 400 ug of CNDs is injected intravenously to mice bearing melanoma cell lines. Gold content is determined from plasma and tissue samples using neutron activation analysis. A physiologically based pharmacokinetic (PBPK) model is developed for 5 nm positive, negative, and neutral and 11 nm negative nanoparticles and extrapolated to 22 nm positive particles. A global sensitivity analysis is performed for estimated model parameters. Negative and neutral particles exhibited similar distribution profiles. Unique model parameter estimates and distribution profiles explain similarities and differences relative to positive particles. The model also explains mechanisms of elimination by kidney and reticuloendothelial uptake in liver and spleen, which varies with particle size and charge. Since the PBPK model can capture the diverse temporal profiles of non-targeted nanoparticles, we propose that when specific binding ligands are lacking, size and charge of nanodevices govern most of their in vivo interactions.
Instrumental neutron activation analysis (INAA) is one of the most widely used analytical methods... more Instrumental neutron activation analysis (INAA) is one of the most widely used analytical methods for bulk chemical characterization of ceramic pastes, owing to its relatively simple sample preparation procedures, the small sample mass required, and low detection limits for most elements of interest. At least fifty major, minor, and trace elements spanning the main geochemical element groups can be readily determined to the percent, ppm or ppb level, although sensitivity varies by element. In this chapter we provide an overview of the fundamental principles of activation analysis, and describe the steps typically followed in sample preparation, irradiation, gamma spectroscopy, and elemental analysis. In addition, we detail the strengths and weaknesses of INAA for archaeological ceramic studies, and illustrate a few of the many applications that have made INAA the mainstay for studies involving ceramic provenance, the organization of pottery production, and ceramic technology.
Page 1. POLITICAL ECONOMY AND MARKET ECONOMY UNDER AZTEC RULE: A REGIONAL PERSPECTIVE BASED ON DE... more Page 1. POLITICAL ECONOMY AND MARKET ECONOMY UNDER AZTEC RULE: A REGIONAL PERSPECTIVE BASED ON DECORATED CERAMIC PRODUCTION AND DISTRIBUTION SYSTEMS IN THE VALLEY OF MEXICO Volume I by Leah Delia Minc ...
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