AimCommon Yoga Protocol (CYP) is a standardized yoga protocol authored by experts from all over t... more AimCommon Yoga Protocol (CYP) is a standardized yoga protocol authored by experts from all over the world under the aegis of the Ministry of AYUSH, Ayurveda, Yoga and Naturopathy, Unani, Siddha, Sowa Rigpa and Homeopathy (AYUSH). The potential of CYP can be determined as a cost-effective lifestyle modification to prevent the risk of developing cardiovascular diseases (CVD).MethodsIn this prospective trial, we compared the effect of CYP at baseline and after 1 month. A total of 374 yoga-naïve participants performed CYP under the supervision of experienced trainers. Physiological [body mass index (BMI), blood pressure, percent oxygen saturation], biochemical (fasting blood glucose and lipid profile), and neurocognitive parameters were measured before and after the intervention.ResultsAt day 30 of yoga practice, serum levels of low-density lipoprotein (LDL), total cholesterol (TC), and high-density lipoprotein (HDL) were found significantly improved as compared to the baseline levels o...
INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, 2019
Research fabrication and data fraud are one of the major concerns worldwide which are rising and ... more Research fabrication and data fraud are one of the major concerns worldwide which are rising and evident from increasing number of retractions in peer reviewed Journals. If not checked, this can impact the reputation of a research organisation as well as the costs of translation of research data. In basic research extremely publicized cases of falsification of data have been reported and it is possible, that there are many unreported or undetected cases. In order to improve the quality standards, the validation processes were implemented for data quality at Neuroscience research lab in India for verifying PhD thesis results. Good Laboratory practices could be implicated in every research institute so that data impostures were prevented. We aimed to establish superior data quality by randomly verifying raw data in multiple projects funded by national agencies before publication of results at Neuroscience Research Lab.
Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2019
BACKGROUND Yoga is an ancient system of wellness with Asana and Pranayama as its most popular and... more BACKGROUND Yoga is an ancient system of wellness with Asana and Pranayama as its most popular and propagated modules for management of lifestyle disorders. OBJECTIVES The aim of the study was to characterise the liver abnormalities, biochemical changes, and stress levels after Yoga intervention in prediabetic females. MATERIALS AND METHODS 37 females were randomly divided into Yoga practising and non-practising control groups. The Yoga practising group performed Diabetic Yoga Protocol (DYP) for 3 months. Parameters including size of liver, fatty infiltration, and grade of severity were measured using ultrasonography along with biochemical parameters and stress levels at baseline and after Yoga practice. RESULTS The glycosylated hemoglobin (HbA1c) and glucose levels were found significantly reduced in prediabetic (p = 0.015) women after practising DYP, although cholesterol levels increased in menopausal women. No escalation of fatty liver was noted among women practising DYP. CONCLUSION DYP reduced the HbA1c and stress levels and therefore, could be a cost-effective tool for preventing prediabetes to diabetes progression.
Background The past three decades have seen palmistry as an interface to human health. There hav... more Background The past three decades have seen palmistry as an interface to human health. There have been no previously organized attempts in utilizing this knowledge to predict the state of disease. Objective Due to unavailability of any biological marker for diagnosing amyotrophic lateral sclerosis (ALS) till date, we attempt to examine whether palmistry could be used for detecting the onset and survival of patient suffering from ALS. Methods Patients suffering from ALS attending the neurology outpatient department at Postgraduate Institute of Medical Education and Research, India were selected for study. Palm photographs were obtained from all patients including controls after their consent. Patients suffering from other comorbidities such as diabetes, hypertension, migraine, as well as smokers and nonsmokers were included in the study. Twenty-six ALS patients, 30 neurological controls, and 34 healthy age matched controls were recruited in the study. Retrospective analysis of the...
This book is about examination of functional relation between language structure, internal brain ... more This book is about examination of functional relation between language structure, internal brain regulatory processes and external processes in nature. Book describes the relation of learning, language and cognitive fitness as adaptive biological interrelations of a process called life. Author describes human being's unique advantage of understanding thought process, language and the reality under the shadow of scientific processes. Evolution of language contributes to the search of novelty of thoughts, behaviour, knowledge, problems, solutions, creativity, learning, innovation, trust and belief in the human kind to serve the horizon. Author linked the evolution of human brain with evolution of primitive language which represented primitive information processing and reasoning. Complexity of language is attributed for understanding complexity of nature to reveal its most dynamic aspects enabling the bigger view of perspective. Linkage of Hippocampus and amygdala to segregate and...
Duchenne Muscular Dystrophy has emerged as a model to assess cognitive domains. The DMD gene vari... more Duchenne Muscular Dystrophy has emerged as a model to assess cognitive domains. The DMD gene variant location and its association with variable degrees of cognitive impairment necessitate identification of a common denominator. Computer architectures provide a framework to delineate the mechanisms involved in the cognitive functioning of the human brain. Copy number variations in the 79 exons of DMD gene were screened in 84 DMD subjects by Multiplex Ligation-dependent Probe Amplification (MLPA). DMD subjects were categorized based on the presence or absence of DP140 isoform. The cognitive and neuropsychological assessments were carried out as per inclusion criteria using standard scales. Instance-based learning theory (IBLT) based on the partial matching process was developed to mimic Stroop Color and Word Task (SCWT) performance on Adaptive Control of Thought-Rational (ACT-R) cognitive architecture based on IBLT. Genotype–phenotype correlation was conducted based on the mutation lo...
Background: The deprivation of oxygen reaching the tissues (also termed as hypoxia) affects the n... more Background: The deprivation of oxygen reaching the tissues (also termed as hypoxia) affects the normal functioning of the body. This results in development of many diseases like ischemia, glaucoma, MCI (Mild Cognitive Impairment), pulmonary and cerebral edema, stress and depression. There are no effective drugs that can treat such diseases. Despite such failure, alternative interventions such as mind-body techniques (MBTs) have not been adequately investigated. Methods: The first part of this review has been focused on philosophical aspects of various MBTs besides evolving an ayurgenomic perspective. The potential of MBTs as a preventive non-pharmacological intervention in the treatment of various general and hypoxic pathologies has been further described in this section. In the second part, molecular, physiological, and neuroprotective roles of MBTs in normal and hypoxic/ischemic conditions has been discussed. Results: In this respect, the importance of and in vivo studies has also...
Background: India is fast becoming the diabetic capital in the world according to a recent report... more Background: India is fast becoming the diabetic capital in the world according to a recent report. Patients with diabetes are at increased risk of mortality due to diabetic complications, which has enormous implications for the health budget. Objectives: The main objective of this review is to provide an overview of the work carried out in the world, including modern and traditional approaches for the prevention and management of diabetes and reducing the chances of onset of further complications via cost-effective lifestyle interventions and integrative medicine. Material and Methods: We performed a literature search from various databases like PubMed, Scopus, Google scholar, etc., using the keywords diabetes, prediabetes, MCI and prediabetes, diabetes and yoga, diabetes. Results: Upon reviewing the published articles, it was noticed that one of the most neglected complications of diabetes, namely cognitive dysfunction, which is characterized by a pattern of vascular dementia and A...
The prevailing system of running research labs in conventional set-ups are based on no uniform me... more The prevailing system of running research labs in conventional set-ups are based on no uniform method of management, relying completely on individual preferences and experiences. Unfortunately, even the leading institutes involved with research in health and medicine fail to incorporate defined modules unless mandated by the guidelines of GMP, essential for clinical translation. The present trend shows the drop in clinical trials presumably due to inherent questionable data and lack of back traceability of information. The ability to bring clinical level safety at the genetic research level facilitates Quality control measures unique, transparent and credible for clinical translation. Good Laboratory Practice (GLP) modules have been developed to enhance quality standards, increase credibility, efficiency and transparency of research settings. The studies in ocular genetics, pathology, pharmacology require similar benchmarks. There have been rapid increase in the cases of eye diseases in Asia but the process of genetic data generation is not uniform and auditable. The studies involving larger populations include meta-analysis and GWAS etc. which require collaborations, need to be supported by a standardized managerial system. Quality standards define such tools ensuring back traceability, verifiability and auditability of data and test systems. These should also address IP conflict management and implementation of standardized protocols. The quality control and GLP can lead to benchmarking of research data which are usually considered a soft activity in Medical Institutes where most of the genetic data is generated. The Quality control practices in such large scale research collaborations require testing the source, prevalence and resulting therapies for overall ocular health.
Chemistry (Weinheim an der Bergstrasse, Germany), Jan 9, 2016
Chiral head groups have been introduced into water-soluble hydroxyl-terminated nonionic amphiphil... more Chiral head groups have been introduced into water-soluble hydroxyl-terminated nonionic amphiphiles and the impact of the head group stereochemistry on the supramolecular ultrastructures has been studied. Enantiomeric isomers were compared with the achiral meso form and the racemic mixture by means of cryogenic transmission electron microscopy and circular dichroism spectroscopy. Structurally, all amphiphiles are composed of the first-generation hydrophilic polyglycerol head group coupled to a single hydrophobic hexadecyl chain through an amide linkage and diaromatic spacer. The enantiomers aggregate to form twisted ribbons with uniform handedness, whereas the meso stereoisomer and racemic mixture produce elongated assemblies, namely, tubules and platelets, but without a chiral ultrastructure. Simulations on the molecular packing geometries of the stereoisomers indicate different preferential assembly routes that explain the individual supramolecular aggregation behavior.
For the first time, it is demonstrated that exposure of an enzyme to anhydrous organic solvents a... more For the first time, it is demonstrated that exposure of an enzyme to anhydrous organic solvents at optimized high temperature enhances its catalytic power through local changes at the binding region. Six enzymes, namely, proteinase K, wheat germ acid phosphatase, alpha-amylase, beta-glucosidase, chymotrypsin and trypsin were exposed to acetonitrile at 70 degrees C for three hr. The activities of these enzymes were found to be considerably enhanced. In order to understand the basis of this change in the activity of these enzymes, proteinase K was analyzed in detail using X-ray diffraction method. The overall structure of the enzyme was found to be similar to the native structure in aqueous environment. The hydrogen bonding system of the catalytic triad remained intact after the treatment. However, the water structure in the substrate binding site underwent some rearrangement as some of the water molecules were either displaced or completely absent. The most striking observation conce...
AimCommon Yoga Protocol (CYP) is a standardized yoga protocol authored by experts from all over t... more AimCommon Yoga Protocol (CYP) is a standardized yoga protocol authored by experts from all over the world under the aegis of the Ministry of AYUSH, Ayurveda, Yoga and Naturopathy, Unani, Siddha, Sowa Rigpa and Homeopathy (AYUSH). The potential of CYP can be determined as a cost-effective lifestyle modification to prevent the risk of developing cardiovascular diseases (CVD).MethodsIn this prospective trial, we compared the effect of CYP at baseline and after 1 month. A total of 374 yoga-naïve participants performed CYP under the supervision of experienced trainers. Physiological [body mass index (BMI), blood pressure, percent oxygen saturation], biochemical (fasting blood glucose and lipid profile), and neurocognitive parameters were measured before and after the intervention.ResultsAt day 30 of yoga practice, serum levels of low-density lipoprotein (LDL), total cholesterol (TC), and high-density lipoprotein (HDL) were found significantly improved as compared to the baseline levels o...
INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, 2019
Research fabrication and data fraud are one of the major concerns worldwide which are rising and ... more Research fabrication and data fraud are one of the major concerns worldwide which are rising and evident from increasing number of retractions in peer reviewed Journals. If not checked, this can impact the reputation of a research organisation as well as the costs of translation of research data. In basic research extremely publicized cases of falsification of data have been reported and it is possible, that there are many unreported or undetected cases. In order to improve the quality standards, the validation processes were implemented for data quality at Neuroscience research lab in India for verifying PhD thesis results. Good Laboratory practices could be implicated in every research institute so that data impostures were prevented. We aimed to establish superior data quality by randomly verifying raw data in multiple projects funded by national agencies before publication of results at Neuroscience Research Lab.
Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2019
BACKGROUND Yoga is an ancient system of wellness with Asana and Pranayama as its most popular and... more BACKGROUND Yoga is an ancient system of wellness with Asana and Pranayama as its most popular and propagated modules for management of lifestyle disorders. OBJECTIVES The aim of the study was to characterise the liver abnormalities, biochemical changes, and stress levels after Yoga intervention in prediabetic females. MATERIALS AND METHODS 37 females were randomly divided into Yoga practising and non-practising control groups. The Yoga practising group performed Diabetic Yoga Protocol (DYP) for 3 months. Parameters including size of liver, fatty infiltration, and grade of severity were measured using ultrasonography along with biochemical parameters and stress levels at baseline and after Yoga practice. RESULTS The glycosylated hemoglobin (HbA1c) and glucose levels were found significantly reduced in prediabetic (p = 0.015) women after practising DYP, although cholesterol levels increased in menopausal women. No escalation of fatty liver was noted among women practising DYP. CONCLUSION DYP reduced the HbA1c and stress levels and therefore, could be a cost-effective tool for preventing prediabetes to diabetes progression.
Background The past three decades have seen palmistry as an interface to human health. There hav... more Background The past three decades have seen palmistry as an interface to human health. There have been no previously organized attempts in utilizing this knowledge to predict the state of disease. Objective Due to unavailability of any biological marker for diagnosing amyotrophic lateral sclerosis (ALS) till date, we attempt to examine whether palmistry could be used for detecting the onset and survival of patient suffering from ALS. Methods Patients suffering from ALS attending the neurology outpatient department at Postgraduate Institute of Medical Education and Research, India were selected for study. Palm photographs were obtained from all patients including controls after their consent. Patients suffering from other comorbidities such as diabetes, hypertension, migraine, as well as smokers and nonsmokers were included in the study. Twenty-six ALS patients, 30 neurological controls, and 34 healthy age matched controls were recruited in the study. Retrospective analysis of the...
This book is about examination of functional relation between language structure, internal brain ... more This book is about examination of functional relation between language structure, internal brain regulatory processes and external processes in nature. Book describes the relation of learning, language and cognitive fitness as adaptive biological interrelations of a process called life. Author describes human being's unique advantage of understanding thought process, language and the reality under the shadow of scientific processes. Evolution of language contributes to the search of novelty of thoughts, behaviour, knowledge, problems, solutions, creativity, learning, innovation, trust and belief in the human kind to serve the horizon. Author linked the evolution of human brain with evolution of primitive language which represented primitive information processing and reasoning. Complexity of language is attributed for understanding complexity of nature to reveal its most dynamic aspects enabling the bigger view of perspective. Linkage of Hippocampus and amygdala to segregate and...
Duchenne Muscular Dystrophy has emerged as a model to assess cognitive domains. The DMD gene vari... more Duchenne Muscular Dystrophy has emerged as a model to assess cognitive domains. The DMD gene variant location and its association with variable degrees of cognitive impairment necessitate identification of a common denominator. Computer architectures provide a framework to delineate the mechanisms involved in the cognitive functioning of the human brain. Copy number variations in the 79 exons of DMD gene were screened in 84 DMD subjects by Multiplex Ligation-dependent Probe Amplification (MLPA). DMD subjects were categorized based on the presence or absence of DP140 isoform. The cognitive and neuropsychological assessments were carried out as per inclusion criteria using standard scales. Instance-based learning theory (IBLT) based on the partial matching process was developed to mimic Stroop Color and Word Task (SCWT) performance on Adaptive Control of Thought-Rational (ACT-R) cognitive architecture based on IBLT. Genotype–phenotype correlation was conducted based on the mutation lo...
Background: The deprivation of oxygen reaching the tissues (also termed as hypoxia) affects the n... more Background: The deprivation of oxygen reaching the tissues (also termed as hypoxia) affects the normal functioning of the body. This results in development of many diseases like ischemia, glaucoma, MCI (Mild Cognitive Impairment), pulmonary and cerebral edema, stress and depression. There are no effective drugs that can treat such diseases. Despite such failure, alternative interventions such as mind-body techniques (MBTs) have not been adequately investigated. Methods: The first part of this review has been focused on philosophical aspects of various MBTs besides evolving an ayurgenomic perspective. The potential of MBTs as a preventive non-pharmacological intervention in the treatment of various general and hypoxic pathologies has been further described in this section. In the second part, molecular, physiological, and neuroprotective roles of MBTs in normal and hypoxic/ischemic conditions has been discussed. Results: In this respect, the importance of and in vivo studies has also...
Background: India is fast becoming the diabetic capital in the world according to a recent report... more Background: India is fast becoming the diabetic capital in the world according to a recent report. Patients with diabetes are at increased risk of mortality due to diabetic complications, which has enormous implications for the health budget. Objectives: The main objective of this review is to provide an overview of the work carried out in the world, including modern and traditional approaches for the prevention and management of diabetes and reducing the chances of onset of further complications via cost-effective lifestyle interventions and integrative medicine. Material and Methods: We performed a literature search from various databases like PubMed, Scopus, Google scholar, etc., using the keywords diabetes, prediabetes, MCI and prediabetes, diabetes and yoga, diabetes. Results: Upon reviewing the published articles, it was noticed that one of the most neglected complications of diabetes, namely cognitive dysfunction, which is characterized by a pattern of vascular dementia and A...
The prevailing system of running research labs in conventional set-ups are based on no uniform me... more The prevailing system of running research labs in conventional set-ups are based on no uniform method of management, relying completely on individual preferences and experiences. Unfortunately, even the leading institutes involved with research in health and medicine fail to incorporate defined modules unless mandated by the guidelines of GMP, essential for clinical translation. The present trend shows the drop in clinical trials presumably due to inherent questionable data and lack of back traceability of information. The ability to bring clinical level safety at the genetic research level facilitates Quality control measures unique, transparent and credible for clinical translation. Good Laboratory Practice (GLP) modules have been developed to enhance quality standards, increase credibility, efficiency and transparency of research settings. The studies in ocular genetics, pathology, pharmacology require similar benchmarks. There have been rapid increase in the cases of eye diseases in Asia but the process of genetic data generation is not uniform and auditable. The studies involving larger populations include meta-analysis and GWAS etc. which require collaborations, need to be supported by a standardized managerial system. Quality standards define such tools ensuring back traceability, verifiability and auditability of data and test systems. These should also address IP conflict management and implementation of standardized protocols. The quality control and GLP can lead to benchmarking of research data which are usually considered a soft activity in Medical Institutes where most of the genetic data is generated. The Quality control practices in such large scale research collaborations require testing the source, prevalence and resulting therapies for overall ocular health.
Chemistry (Weinheim an der Bergstrasse, Germany), Jan 9, 2016
Chiral head groups have been introduced into water-soluble hydroxyl-terminated nonionic amphiphil... more Chiral head groups have been introduced into water-soluble hydroxyl-terminated nonionic amphiphiles and the impact of the head group stereochemistry on the supramolecular ultrastructures has been studied. Enantiomeric isomers were compared with the achiral meso form and the racemic mixture by means of cryogenic transmission electron microscopy and circular dichroism spectroscopy. Structurally, all amphiphiles are composed of the first-generation hydrophilic polyglycerol head group coupled to a single hydrophobic hexadecyl chain through an amide linkage and diaromatic spacer. The enantiomers aggregate to form twisted ribbons with uniform handedness, whereas the meso stereoisomer and racemic mixture produce elongated assemblies, namely, tubules and platelets, but without a chiral ultrastructure. Simulations on the molecular packing geometries of the stereoisomers indicate different preferential assembly routes that explain the individual supramolecular aggregation behavior.
For the first time, it is demonstrated that exposure of an enzyme to anhydrous organic solvents a... more For the first time, it is demonstrated that exposure of an enzyme to anhydrous organic solvents at optimized high temperature enhances its catalytic power through local changes at the binding region. Six enzymes, namely, proteinase K, wheat germ acid phosphatase, alpha-amylase, beta-glucosidase, chymotrypsin and trypsin were exposed to acetonitrile at 70 degrees C for three hr. The activities of these enzymes were found to be considerably enhanced. In order to understand the basis of this change in the activity of these enzymes, proteinase K was analyzed in detail using X-ray diffraction method. The overall structure of the enzyme was found to be similar to the native structure in aqueous environment. The hydrogen bonding system of the catalytic triad remained intact after the treatment. However, the water structure in the substrate binding site underwent some rearrangement as some of the water molecules were either displaced or completely absent. The most striking observation conce...
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