Table 1.
Baseline characteristics of adults with CBC-derived inflammatory biomarkers in NHANES 1999–2006
| Characteristics | Total (n = 12,689) | Sarcopenia | P value | ||
|---|---|---|---|---|---|
| No (n = 10,964) | Yes (n = 1725) | ||||
| Age, years | < 0.001 | ||||
| <39 | 4449 (35.1) | 4220 (38.5) | 229 (13.3) | ||
| 40–59 | 4240 (33.4) | 3822 (34.9) | 418 (24.2) | ||
| > 59 | 4000 (31.5) | 2922 (26.7) | 1078 (62.5) | ||
| Male, % | 6471 (51.0) | 5537 (50.5) | 934 (54.1) | 0.005 | |
| Race/ethnicity, % | < 0.001 | ||||
| Mexican American | 2951 (23.3) | 2181 (19.9) | 770 (44.6) | ||
| Other Hispanic | 568 (4.5) | 469 (4.3) | 99 (5.7) | ||
| Non-Hispanic White | 6389 (50.4) | 5647 (51.5) | 742 (43.0) | ||
| Non-Hispanic Black | 2329 (18.4) | 2271 (20.7) | 58 (3.4) | ||
| Other race | 452 (3.6) | 396 (3.6) | 56 (3.2) | ||
| Education level, % | < 0.001 | ||||
| Below high school | 3881 (30.6) | 3017 (27.5) | 864 (50.1) | ||
| High school | 3012 (23.7) | 2631 (24.0) | 381 (22.1) | ||
| Above high school | 5796 (45.7) | 5316 (48.5) | 480 (27.8) | ||
| Family PIR, % | < 0.001 | ||||
| ≤ 1.0 | 2240 (17.7) | 1833 (16.7) | 407 (23.6) | ||
| 1.1–3.0 | 5187 (40.9) | 4326 (39.5) | 861 (49.9) | ||
| > 3.0 | 5262 (41.5) | 4805 (43.8) | 457 (26.5) | ||
| Smoking status, % | < 0.001 | ||||
| Never smoker | 6427 (50.7) | 5574 (50.8) | 853 (49.4) | ||
| Former smoker | 3246 (25.6) | 2663 (24.3) | 583 (33.8) | ||
| Current smoker | 3016 (23.8) | 2727 (24.9) | 289 (16.8) | ||
| Drinking status, % | < 0.001 | ||||
| Nondrinker | 2819 (22.2) | 2291 (20.9) | 528 (30.6) | ||
| Low-to-moderate drinker | 8740 (68.9) | 7645 (69.7) | 1095 (63.5) | ||
| Heavy drinker | 1130 (8.9) | 1028 (9.4) | 102 (5.9) | ||
| Physical activity, % | < 0.001 | ||||
| Inactive | 3396 (26.8) | 2716 (24.8) | 680 (39.4) | ||
| Insufficiently active | 6290 (49.6) | 5563 (50.7) | 727 (42.1) | ||
| Active | 3003 (23.7) | 2685 (24.5) | 318 (18.4) | ||
| Total energy intakes, kcal/day | 1962.00 [1438.00, 2643.00] | 2017.49 [1480.45, 2712.83] | 1656.00 [1223.79, 2194.10] | < 0.001 | |
| Self-reported hypertension, % | 3727 (29.4) | 2971 (27.1) | 756 (43.8) | < 0.001 | |
| Self-reported diabetes, % | 1150 (9.1) | 830 (7.6) | 320 (18.6) | < 0.001 | |
| CBC count, 103/µL | |||||
| White blood cell | 6.90 [5.70, 8.20] | 6.80 [5.60, 8.20] | 7.20 [6.10, 8.60] | < 0.001 | |
| Neutrophils | 4.00 [3.10, 5.10] | 3.90 [3.10, 5.00] | 4.30 [3.40, 5.30] | < 0.001 | |
| Monocyte | 0.50 [0.40, 0.60] | 0.50 [0.40, 0.60] | 0.60 [0.50, 0.70] | < 0.001 | |
| Lymphocyte | 2.00 [1.60, 2.50] | 2.00 [1.60, 2.50] | 2.00 [1.60, 2.50] | 0.466 | |
| CBC-derived indicators | |||||
| NLR | 1.95 [1.48, 2.60] | 1.93 [1.46, 2.56] | 2.12 [1.60, 2.80] | < 0.001 | |
| dNLR | 1.42 [1.10, 1.80] | 1.40 [1.09, 1.79] | 1.52 [1.18, 1.90] | < 0.001 | |
| MLR | 0.26 [0.21, 0.33] | 0.25 [0.20, 0.33] | 0.27 [0.21, 0.36] | < 0.001 | |
| NMLR | 2.21 [1.71, 2.91] | 2.19 [1.69, 2.87] | 2.40 [1.83, 3.15] | < 0.001 | |
| SIRI, 103/µL | 1.02 [0.71, 1.48] | 1.00 [0.70, 1.44] | 1.18 [0.80, 1.69] | < 0.001 | |
| SII, 103/µL | 509.22 [367.88, 707.44] | 504.67 [364.50, 700.62] | 546.54 [392.33, 763.82] | < 0.001 | |
Abbreviations: PIR, poverty income ratio; NLR, neutrophil-to-lymphocyte ratio; dNLR, derived neutrophil-to-lymphocyte ratio; MLR, monocyte-to-lymphocyte ratio; NMLR, neutrophil-monocyte to lymphocyte ratio; SIRI, systemic inflammatory response index; SII, systemic immune-inflammation index; CBC, complete blood cell
Continuous variables without a normal distribution are presented as medians [interquartile ranges]. Categorical variables are presented as numbers (percentages). The Benjamini-Hochberg method was used to adjust p values for multiple testing