Table 2.
OR (95% CIs) of the prevalence of sarcopenia according to quartiles of complete blood cell (CBC)-derived inflammatory biomarkers among adults in NHANES 1999–2006
| Quartiles of CBC-derived inflammatory biomarkers levels | P trend | ||||
|---|---|---|---|---|---|
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | ||
| NLR | |||||
| Range | < 1.48 | 1.48–1.95 | 1.96–2.60 | > 2.60 | |
| Crude | 1 [Reference] | 1.194 (1.023–1.395) | 1.450 (1.247–1.686) | 1.748 (1.510–2.026) | < 0.001 |
| Model 1 | 1 [Reference] | 0.984 (0.835–1.159) | 1.162 (0.990–1.364) | 1.296 (1.107–1.518) | < 0.001 |
| Model 2 | 1 [Reference] | 0.985 (0.836–1.161) | 1.157 (0.986–1.359) | 1.215 (1.037–1.425) | 0.004 |
| dNLR | |||||
| Range | < 1.10 | 1.10–1.42 | 1.43–1.80 | > 1.80 | |
| Crude | 1 [Reference] | 1.186 (1.017–1.383) | 1.397 (1.204–1.623) | 1.620 (1.400-1.877) | < 0.001 |
| Model 1 | 1 [Reference] | 0.998 (0.849–1.175) | 1.150 (0.982–1.349) | 1.261 (1.079–1.475) | < 0.001 |
| Model 2 | 1 [Reference] | 0.971 (0.825–1.143) | 1.159 (0.988–1.359) | 1.177 (1.006–1.378) | 0.008 |
| MLR | |||||
| Range | < 0.21 | 0.21–0.26 | 0.27–0.33 | > 0.33 | |
| Crude | 1 [Reference] | 0.979 (0.842–1.139) | 1.073 (0.924–1.247) | 1.408 (1.225–1.618) | < 0.001 |
| Model 1 | 1 [Reference] | 0.840 (0.715–0.987) | 0.842 (0.716–0.991) | 1.048 (0.896–1.226) | 0.381 |
| Model 2 | 1 [Reference] | 0.823 (0.700-0.968) | 0.822 (0.699–0.967) | 1.004 (0.857–1.176) | 0.705 |
| NMLR | |||||
| Range | < 1.71 | 1.71–2.21 | 2.22–2.91 | > 2.91 | |
| Crude | 1 [Reference] | 1.219 (1.044–1.423) | 1.411 (1.213–1.642) | 1.766 (1.527–2.045) | < 0.001 |
| Model 1 | 1 [Reference] | 1.006 (0.854–1.185) | 1.142 (0.973–1.342) | 1.305 (1.115–1.529) | < 0.001 |
| Model 2 | 1 [Reference] | 1.001 (0.850–1.180) | 1.140 (0.971–1.340) | 1.226 (1.046–1.437) | 0.004 |
| SIRI | |||||
| Range | < 0.71 | 0.71–1.02 | 1.03–1.48 | > 1.48 | |
| Crude | 1 [Reference] | 1.314 (1.123–1.538) | 1.523 (1.306–1.776) | 1.997 (1.723–2.317) | < 0.001 |
| Model 1 | 1 [Reference] | 1.046 (0.886–1.235) | 1.184 (1.005–1.395) | 1.525 (1.299–1.792) | < 0.001 |
| Model 2 | 1 [Reference] | 1.016 (0.861–1.201) | 1.138 (0.966–1.342) | 1.397 (1.188–1.645) | < 0.001 |
| SII | |||||
| Range | < 367.88 | 367.88-509.22 | 509.23-7707.44 | > 707.44 | |
| Crude | 1 [Reference] | 1.155 (0.993–1.343) | 1.309 (1.129–1.518) | 1.470 (1.271-1.700) | < 0.001 |
| Model 1 | 1 [Reference] | 0.999 (0.852–1.173) | 1.218 (1.041–1.425) | 1.357 (1.163–1.585) | < 0.001 |
| Model 2 | 1 [Reference] | 1.001 (0.853–1.176) | 1.226 (1.047–1.437) | 1.311 (1.122–1.533) | < 0.001 |
The Benjamini-Hochberg method was used to adjust p values for multiple testing. Model 1 was adjusted as age (< 39, 40–59, or > 59), sex (male or female), and race/ethnicity (Mexican American, Other Hispanic, Non-Hispanic White, Non-Hispanic Black or Other); Model 2 was adjusted as model 1 plus education level (below high school, high school, or above high school), family poverty income ratio (≤ 1.0, 1.1–3.0, or > 3.0), drinking status (nondrinker, low-to-moderate drinker, or heavy drinker), smoking status (never smoker, former smoker, or current smoker), physical activity (inactive, insufficiently active, or active), total energy intakes (in quartiles), self-reported diabetes (yes or no), and self-reported hypertension (yes or no)