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American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 1999 Jul;65(1):208–219. doi: 10.1086/302451

Sex-specific migration patterns in Central Asian populations, revealed by analysis of Y-chromosome short tandem repeats and mtDNA.

A Pérez-Lezaun 1, F Calafell 1, D Comas 1, E Mateu 1, E Bosch 1, R Martínez-Arias 1, J Clarimón 1, G Fiori 1, D Luiselli 1, F Facchini 1, D Pettener 1, J Bertranpetit 1
PMCID: PMC1378092  PMID: 10364534

Abstract

Eight Y-linked short-tandem-repeat polymorphisms (DYS19, DYS388, DYS389I, DYS389II, DYS390, DYS391, DYS392, and DYS393) were analyzed in four populations of Central Asia, comprising two lowland samples-Uighurs and lowland Kirghiz-and two highland samples-namely, the Kazakhs (altitude 2,500 m above sea level) and highland Kirghiz (altitude 3,200 m above sea level). The results were compared with mtDNA sequence data on the same individuals, to study possible differences in male versus female genetic-variation patterns in these Central Asian populations. Analysis of molecular variance (AMOVA) showed a very high degree of genetic differentiation among the populations tested, in discordance with the results obtained with mtDNA sequences, which showed high homogeneity. Moreover, a dramatic reduction of the haplotype genetic diversity was observed in the villages at high altitude, especially in the highland Kirghiz, when compared with the villages at low altitude, which suggests a male founder effect in the settlement of high-altitude lands. Nonetheless, mtDNA genetic diversity in these highland populations is equivalent to that in the lowland populations. The present results suggest a very different migration pattern in males versus females, in an extended historical frame, with a higher migration rate for females.

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Selected References

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  1. Bamshad M. J., Watkins W. S., Dixon M. E., Jorde L. B., Rao B. B., Naidu J. M., Prasad B. V., Rasanayagam A., Hammer M. F. Female gene flow stratifies Hindu castes. Nature. 1998 Oct 15;395(6703):651–652. doi: 10.1038/27103. [DOI] [PubMed] [Google Scholar]
  2. Barbujani G., Magagni A., Minch E., Cavalli-Sforza L. L. An apportionment of human DNA diversity. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4516–4519. doi: 10.1073/pnas.94.9.4516. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Barbujani G., Sokal R. R. Zones of sharp genetic change in Europe are also linguistic boundaries. Proc Natl Acad Sci U S A. 1990 Mar;87(5):1816–1819. doi: 10.1073/pnas.87.5.1816. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bianchi N. O., Catanesi C. I., Bailliet G., Martinez-Marignac V. L., Bravi C. M., Vidal-Rioja L. B., Herrera R. J., López-Camelo J. S. Characterization of ancestral and derived Y-chromosome haplotypes of New World native populations. Am J Hum Genet. 1998 Dec;63(6):1862–1871. doi: 10.1086/302141. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cooper G., Amos W., Hoffman D., Rubinsztein D. C. Network analysis of human Y microsatellite haplotypes. Hum Mol Genet. 1996 Nov;5(11):1759–1766. doi: 10.1093/hmg/5.11.1759. [DOI] [PubMed] [Google Scholar]
  6. Deka R., Jin L., Shriver M. D., Yu L. M., Saha N., Barrantes R., Chakraborty R., Ferrell R. E. Dispersion of human Y chromosome haplotypes based on five microsatellites in global populations. Genome Res. 1996 Dec;6(12):1177–1184. doi: 10.1101/gr.6.12.1177. [DOI] [PubMed] [Google Scholar]
  7. Excoffier L., Smouse P. E., Quattro J. M. Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data. Genetics. 1992 Jun;131(2):479–491. doi: 10.1093/genetics/131.2.479. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Forster P., Harding R., Torroni A., Bandelt H. J. Origin and evolution of Native American mtDNA variation: a reappraisal. Am J Hum Genet. 1996 Oct;59(4):935–945. [PMC free article] [PubMed] [Google Scholar]
  9. Hammer M. F., Spurdle A. B., Karafet T., Bonner M. R., Wood E. T., Novelletto A., Malaspina P., Mitchell R. J., Horai S., Jenkins T. The geographic distribution of human Y chromosome variation. Genetics. 1997 Mar;145(3):787–805. doi: 10.1093/genetics/145.3.787. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Huoponen K., Torroni A., Wickman P. R., Sellitto D., Gurley D. S., Scozzari R., Wallace D. C. Mitochondrial DNA and Y chromosome-specific polymorphisms in the Seminole Tribe of Florida. Eur J Hum Genet. 1997 Jan-Feb;5(1):25–34. [PubMed] [Google Scholar]
  11. Jazin E., Soodyall H., Jalonen P., Lindholm E., Stoneking M., Gyllensten U. Mitochondrial mutation rate revisited: hot spots and polymorphism. Nat Genet. 1998 Feb;18(2):109–110. doi: 10.1038/ng0298-109. [DOI] [PubMed] [Google Scholar]
  12. Jobling M. A., Pandya A., Tyler-Smith C. The Y chromosome in forensic analysis and paternity testing. Int J Legal Med. 1997;110(3):118–124. doi: 10.1007/s004140050050. [DOI] [PubMed] [Google Scholar]
  13. Kayser M., Caglià A., Corach D., Fretwell N., Gehrig C., Graziosi G., Heidorn F., Herrmann S., Herzog B., Hidding M. Evaluation of Y-chromosomal STRs: a multicenter study. Int J Legal Med. 1997;110(3):125-33, 141-9. doi: 10.1007/s004140050051. [DOI] [PubMed] [Google Scholar]
  14. Malaspina P., Cruciani F., Ciminelli B. M., Terrenato L., Santolamazza P., Alonso A., Banyko J., Brdicka R., García O., Gaudiano C. Network analyses of Y-chromosomal types in Europe, northern Africa, and western Asia reveal specific patterns of geographic distribution. Am J Hum Genet. 1998 Sep;63(3):847–860. doi: 10.1086/301999. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Parsons T. J., Muniec D. S., Sullivan K., Woodyatt N., Alliston-Greiner R., Wilson M. R., Berry D. L., Holland K. A., Weedn V. W., Gill P. A high observed substitution rate in the human mitochondrial DNA control region. Nat Genet. 1997 Apr;15(4):363–368. doi: 10.1038/ng0497-363. [DOI] [PubMed] [Google Scholar]
  16. Passarino G., Semino O., Quintana-Murci L., Excoffier L., Hammer M., Santachiara-Benerecetti A. S. Different genetic components in the Ethiopian population, identified by mtDNA and Y-chromosome polymorphisms. Am J Hum Genet. 1998 Feb;62(2):420–434. doi: 10.1086/301702. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Pena S. D., Santos F. R., Bianchi N. O., Bravi C. M., Carnese F. R., Rothhammer F., Gerelsaikhan T., Munkhtuja B., Oyunsuren T. A major founder Y-chromosome haplotype in Amerindians. Nat Genet. 1995 Sep;11(1):15–16. doi: 10.1038/ng0995-15. [DOI] [PubMed] [Google Scholar]
  18. Pestoni C., Cal M. L., Lareu M. V., Rodríguez-Calvo M. S., Carracedo A. Y chromosome STR haplotypes: genetic and sequencing data of the Galician population (NW Spain). Int J Legal Med. 1998;112(1):15–21. doi: 10.1007/s004140050191. [DOI] [PubMed] [Google Scholar]
  19. Poloni E. S., Semino O., Passarino G., Santachiara-Benerecetti A. S., Dupanloup I., Langaney A., Excoffier L. Human genetic affinities for Y-chromosome P49a,f/TaqI haplotypes show strong correspondence with linguistics. Am J Hum Genet. 1997 Nov;61(5):1015–1035. doi: 10.1086/301602. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Pérez-Lezaun A., Calafell F., Seielstad M., Mateu E., Comas D., Bosch E., Bertranpetit J. Population genetics of Y-chromosome short tandem repeats in humans. J Mol Evol. 1997 Sep;45(3):265–270. doi: 10.1007/pl00006229. [DOI] [PubMed] [Google Scholar]
  21. Rolf B., Meyer E., Brinkmann B., de Knijff P. Polymorphism at the tetranucleotide repeat locus DYS389 in 10 populations reveals strong geographic clustering. Eur J Hum Genet. 1998 Nov-Dec;6(6):583–588. doi: 10.1038/sj.ejhg.5200223. [DOI] [PubMed] [Google Scholar]
  22. Salem A. H., Badr F. M., Gaballah M. F., Päbo S. The genetics of traditional living: Y-chromosomal and mitochondrial lineages in the Sinai Peninsula. Am J Hum Genet. 1996 Sep;59(3):741–743. [PMC free article] [PubMed] [Google Scholar]
  23. Santos F. R., Pena S. D., Epplen J. T. Genetic and population study of a Y-linked tetranucleotide repeat DNA polymorphism with a simple non-isotopic technique. Hum Genet. 1993 Feb;90(6):655–656. doi: 10.1007/BF00202486. [DOI] [PubMed] [Google Scholar]
  24. Seielstad M. T., Minch E., Cavalli-Sforza L. L. Genetic evidence for a higher female migration rate in humans. Nat Genet. 1998 Nov;20(3):278–280. doi: 10.1038/3088. [DOI] [PubMed] [Google Scholar]
  25. Stoneking M. Women on the move. Nat Genet. 1998 Nov;20(3):219–220. doi: 10.1038/3012. [DOI] [PubMed] [Google Scholar]
  26. Torroni A., Schurr T. G., Yang C. C., Szathmary E. J., Williams R. C., Schanfield M. S., Troup G. A., Knowler W. C., Lawrence D. N., Weiss K. M. Native American mitochondrial DNA analysis indicates that the Amerind and the Nadene populations were founded by two independent migrations. Genetics. 1992 Jan;130(1):153–162. doi: 10.1093/genetics/130.1.153. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Underhill P. A., Jin L., Lin A. A., Mehdi S. Q., Jenkins T., Vollrath D., Davis R. W., Cavalli-Sforza L. L., Oefner P. J. Detection of numerous Y chromosome biallelic polymorphisms by denaturing high-performance liquid chromatography. Genome Res. 1997 Oct;7(10):996–1005. doi: 10.1101/gr.7.10.996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Underhill P. A., Jin L., Zemans R., Oefner P. J., Cavalli-Sforza L. L. A pre-Columbian Y chromosome-specific transition and its implications for human evolutionary history. Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):196–200. doi: 10.1073/pnas.93.1.196. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Wakeley J. Substitution rate variation among sites in hypervariable region 1 of human mitochondrial DNA. J Mol Evol. 1993 Dec;37(6):613–623. doi: 10.1007/BF00182747. [DOI] [PubMed] [Google Scholar]
  30. Weber J. L., Wong C. Mutation of human short tandem repeats. Hum Mol Genet. 1993 Aug;2(8):1123–1128. doi: 10.1093/hmg/2.8.1123. [DOI] [PubMed] [Google Scholar]

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