Receptor D1 de dopamina

O receptor de dopamina D₁, também conhecido como D1R, é uma proteína que, em seres humanos é codificada pelo gene DRD1. Funciona como um receptor acoplado à proteína G.

DRD1
Estruturas disponíveis PDB Pesquisa Human UniProt: PDBe RCSB Lista de códigos id do PDB 1OZ5
Identificadores
Nomes alternativos	DRD1
IDs externos	OMIM: 126449 HomoloGene: 30992 GeneCards: DRD1
Targeted by Drug
A-68930, apomorfina, cabergolina, dopamina, fenoldopam, pergolide, Rotigotina, serotonina, bromocriptina, lisurida, SKF-38393, (+)-butaclamol, clorpromazina, clozapina, ecopipam, Flupentixol, flufenazina, haloperidol, cetanserina, mesoridazine, Proclorperazina, SCH-23390, espiperona, thioridazine, tavapadon, pimozida, fenoldopam, pergolide mesylate
Ontologia genética Função molecular • dopamine neurotransmitter receptor activity • dopamine binding • GO:0001948, GO:0016582 ligação a proteínas plasmáticas • dopamine neurotransmitter receptor activity, coupled via Gs • G protein-coupled receptor activity • signal transducer activity • G-protein alpha-subunit binding Componente celular • membrane • núcleo celular • retículo endoplasmático • integral component of membrane • membrana plasmática • endoplasmic reticulum membrane • integral component of plasma membrane • ciliary membrane • sistema endomembranoso • non-motile cilium • glutamatergic synapse • GABA-ergic synapse • integral component of postsynaptic membrane • integral component of presynaptic membrane • Espinha dendrítica • dendrito • cell projection • cílio Processo biológico • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway • contracção muscular • protein import into nucleus • positive regulation of potassium ion transport • response to amphetamine • aprendizagem • feeding behavior • Depressão de longa duração • temperature homeostasis • striatum development • prepulse inhibition • response to cocaine • grooming behavior • behavioral response to cocaine • locomotory behavior • dentate gyrus development • transmission of nerve impulse • memória • positive regulation of synaptic transmission, glutamatergic • Sinaptogênese • habituação • adult walking behavior • movimento peristáltico • cellular response to catecholamine stimulus • adenylate cyclase-activating dopamine receptor signaling pathway • regulation of dopamine uptake involved in synaptic transmission • associative learning • astrocyte development • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • positive regulation of release of sequestered calcium ion into cytosol • mating behavior • behavioral fear response • activation of adenylate cyclase activity • dopamine receptor signaling pathway • Aversão ao sabor condicionada • cerebral cortex GABAergic interneuron migration • glucose import • visual learning • sensitization • positive regulation of cell migration • condicionamento operante • vasodilatação • regulation of dopamine metabolic process • dopamine metabolic process • phospholipase C-activating dopamine receptor signaling pathway • maternal behavior • dopamine transport • hippocampus development • neuronal action potential • Potenciação de longa duração • GO:0072468 transdução de sinal • synaptic transmission, dopaminergic • GO:1901313 positive regulation of gene expression • cellular response to dopamine • regulation of protein phosphorylation • G protein-coupled receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of synaptic vesicle exocytosis Sources:Amigo / QuickGO
Padrão de expressão RNA Mais dados de referência de expressão
Ortólogos Espécie Humano Rato Entrez 1812 n/a Ensembl ENSG00000184845 n/a UniProt P21728 n/a RefSeq (mRNA) NM_000794 n/a RefSeq (proteína) NP_000785 n/a Localização (UCSC) n/a n/a Pesquisa PubMed n/a
Wikidata
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