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The growing applications of click chemistry

Chem Soc Rev. 2007 Aug;36(8):1249-62. doi: 10.1039/b613014n. Epub 2007 May 3.

Abstract

Click chemistry, the subject of this tutorial review, is a modular synthetic approach towards the assembly of new molecular entities. This powerful strategy relies mainly upon the construction of carbon-heteroatom bonds using spring-loaded reactants. Its growing number of applications are found in nearly all areas of modern chemistry from drug discovery to materials science. The copper(I)-catalysed 1,2,3-triazole forming reaction between azides and terminal alkynes has become the gold standard of click chemistry due to its reliability, specificity and biocompatibility.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alkynes / chemistry
  • Azides / chemistry
  • Catalysis
  • Combinatorial Chemistry Techniques / methods*
  • Copper / chemistry
  • Cross-Linking Reagents
  • Drug Design*
  • Triazoles / chemistry

Substances

  • Alkynes
  • Azides
  • Cross-Linking Reagents
  • Triazoles
  • Copper